• 7188 Citations
  • 24 h-Index
19992019

Research output per year

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Publications

2019

Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs

Song, Y., van den Berg, P. R., Markoulaki, S., Soldner, F., Dall'Agnese, A., Henninger, J. E., Drotar, J., Rosenau, N., Cohen, M. A., Young, R. A., Semrau, S., Stelzer, Y. & Jaenisch, R., Sep 5 2019, In : Molecular Cell. 75, 5, p. 905-920.e6

Research output: Contribution to journalArticle

4 Scopus citations

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

Fanning, S., Haque, A., Imberdis, T., Baru, V., Barrasa, M. I., Nuber, S., Termine, D., Ramalingam, N., Ho, G. P. H., Noble, T., Sandoe, J., Lou, Y., Landgraf, D., Freyzon, Y., Newby, G., Soldner, F., Terry-Kantor, E., Kim, T. E., Hofbauer, H. F., Becuwe, M. & 11 others, Jaenisch, R., Pincus, D., Clish, C. B., Walther, T. C., Farese, R. V., Srinivasan, S., Welte, M. A., Kohlwein, S. D., Dettmer, U., Lindquist, S. & Selkoe, D., Mar 7 2019, In : Molecular Cell. 73, 5, p. 1001-1014.e8

Research output: Contribution to journalArticle

22 Scopus citations
2018

Stem Cells, Genome Editing, and the Path to Translational Medicine

Soldner, F. & Jaenisch, R., Oct 18 2018, In : Cell. 175, 3, p. 615-632 18 p.

Research output: Contribution to journalReview article

Open Access
25 Scopus citations
2017

In vitro modeling of complex neurological diseases

Soldner, F. & Jaenisch, R., Jan 1 2017, Research and Perspectives in Neurosciences. 9783319601915 ed. Springer Verlag, p. 1-19 19 p. (Research and Perspectives in Neurosciences; no. 9783319601915).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models

Oh, C. K., Sultan, A., Platzer, J., Dolatabadi, N., Soldner, F., McClatchy, D. B., Diedrich, J. K., Yates, J. R., Ambasudhan, R., Nakamura, T., Jaenisch, R. & Lipton, S. A., Nov 21 2017, In : Cell Reports. 21, 8, p. 2171-2182 12 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations
2016

Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression

Soldner, F., Stelzer, Y., Shivalila, C. S., Abraham, B. J., Latourelle, J. C., Barrasa, M. I., Goldmann, J., Myers, R. H., Young, R. A. & Jaenisch, R., May 5 2016, In : Nature. 533, 7601, p. 95-99 5 p.

Research output: Contribution to journalArticle

225 Scopus citations
2015

Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders

Brennand, K. J., Marchetto, M. C., Benvenisty, N., Brüstle, O., Ebert, A., Izpisua Belmonte, J. C., Kaykas, A., Lancaster, M. A., Livesey, F. J., McConnell, M. J., McKay, R. D., Morrow, E. M., Muotri, A. R., Panchision, D. M., Rubin, L. L., Sawa, A., Soldner, F., Song, H., Studer, L., Temple, S. & 5 others, Vaccarino, F. M., Wu, J., Vanderhaeghen, P., Gage, F. H. & Jaenisch, R., Dec 8 2015, In : Stem Cell Reports. 5, 6, p. 933-945 13 p.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations

Dissecting risk haplotypes in sporadic Alzheimer's disease

Soldner, F. & Jaenisch, R., Apr 2 2015, In : Cell Stem Cell. 16, 4, p. 341-342 2 p.

Research output: Contribution to journalShort survey

Open Access
5 Scopus citations

Erratum: Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation (Nature Communications (2015) 6:7314 DOI: 10.1038/ncomms8314)

Dettmer, U., Newman, A. J., Soldner, F., Luth, E. S., Kim, N. C., Von Saucken, V. E., Sanderson, J. B., Jaenisch, R., Bartels, T. & Selkoe, D., Jul 30 2015, In : Nature communications. 6, 8008.

Research output: Contribution to journalComment/debate

Open Access
4 Scopus citations

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

Dettmer, U., Newman, A. J., Soldner, F., Luth, E. S., Kim, N. C., Von Saucken, V. E., Sanderson, J. B., Jaenisch, R., Bartels, T. & Selkoe, D., Jun 16 2015, In : Nature communications. 6, 7314.

Research output: Contribution to journalArticle

Open Access
131 Scopus citations

Tracing Dynamic Changes of DNA Methylation at Single-Cell Resolution

Stelzer, Y., Shivalila, C. S., Soldner, F., Markoulaki, S. & Jaenisch, R., Sep 24 2015, In : Cell. 163, 1, p. 218-229 12 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations
2014

Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication

Flierl, A., Oliveira, L. M. A., Falomir-Lockhart, L. J., Mak, S. K., Hesley, J., Soldner, F., Arndt-Jovin, D. J., Jaenisch, R., Langston, J. W., Jovin, T. M. & Le, B. S., Nov 12 2014, In : PloS one. 9, 11, e112413.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations
2013

Erratum: Isogenic human iPSC parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription (Cell (2013) 155 (1351-1364))

Ryan, S. D., Dolatabadi, N., Chan, S. F., Zhang, X., Akhtar, M. W., Parker, J., Soldner, F., Sunico, C. R., Nagar, S., Talantova, M., Lee, B., Lopez, K., Nutter, A., Shan, B., Molokanova, E., Zhang, Y., Han, X., Nakamura, T., Masliah, E., Yates, J. R. & 6 others, Nakanishi, N., Andreyev, A. Y., Okamoto, S. I., Jaenisch, R., Ambasudhan, R. & Lipton, S. A., Dec 19 2013, In : Cell. 155, 7, p. 1652-1653 2 p.

Research output: Contribution to journalComment/debate

Open Access
4 Scopus citations

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons

Chung, C. Y., Khurana, V., Auluck, P. K., Tardiff, D. F., Mazzulli, J. R., Soldner, F., Baru, V., Lou, Y., Freyzon, Y., Cho, S., Mungenast, A. E., Muffat, J., Mitalipova, M., Pluth, M. D., Jui, N. T., Schul̈e, B., Lippard, S. J., Tsai, L. H., Krainc, D., Buchwald, S. L. & 2 others, Jaenisch, R. & Lindquist, S., Jan 1 2013, In : Science. 342, 6161, p. 983-987 5 p.

Research output: Contribution to journalArticle

259 Scopus citations

Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

Ambasudhan, R., Ryan, S. D., Dolatabadi, N., Chan, S. F., Zhang, X., Akhtar, M. W., Parker, J., Soldner, F., Sunico, C. R., Nagar, S., Talantova, M., Lee, B., Lopez, K., Nutter, A., Shan, B., Molokanova, E., Zhang, Y., Han, X., Nakamura, T., Masliah, E. & 6 others, Yates, J. R., Nakanishi, N., Andreyev, A. Y., Okamoto, S. I., Jaenisch, R. & Lipton, S. A., Dec 5 2013, In : Cell. 155, 6, 1 p.

Research output: Contribution to journalArticle

Open Access
210 Scopus citations

Toward eliminating HLA class i expression to generate universal cells from allogeneic donors

Torikai, H., Reik, A., Soldner, F., Warren, E. H., Yuen, C., Zhou, Y., Crossland, D. L., Huls, H., Littman, N., Zhang, Z., Tykodi, S. S., Kebriaei, P., Lee, D. A., Miller, J. C., Rebar, E. J., Holmes, M. C., Jaenisch, R., Champlin, R. E., Gregory, P. D. & Cooper, L. J. N., Jan 1 2013, In : Blood. 122, 8, p. 1341-1349 9 p.

Research output: Contribution to journalArticle

Open Access
120 Scopus citations
2012

iPSC disease modeling

Soldner, F. & Jaenisch, R., Nov 30 2012, In : Science. 338, 6111, p. 1155-1156 2 p.

Research output: Contribution to journalShort survey

96 Scopus citations
2011

Erratum: Generation of isogenic pluripotent stem cells differing exclusively at two early onset parkinson point mutations (Cell (2011) 146 (318-331))

Soldner, F., Laganière, J., Cheng, A. W., Hockemeyer, D., Gao, Q., Alagappan, R., Khurana, V., Golbe, L. I., Myers, R. H., Lindquist, S., Zhang, L., Guschin, D., Fong, L. K., Vu, B. J., Meng, X., Urnov, F. D., Rebar, E. J., Gregory, P. D., Zhang, H. S. & Jaenisch, R., Aug 19 2011, In : Cell. 146, 4, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Generation of isogenic pluripotent stem cells differing exclusively at two early onset parkinson point mutations

Soldner, F., Laganière, J., Cheng, A. W., Hockemeyer, D., Gao, Q., Alagappan, R., Khurana, V., Golbe, L. I., Myers, R. H., Lindquist, S., Zhang, L., Guschin, D., Fong, L. K., Vu, B. J., Meng, X., Urnov, F. D., Rebar, E. J., Gregory, P. D., Zhang, H. S. & Jaenisch, R., Jul 22 2011, In : Cell. 146, 2, p. 318-331 14 p.

Research output: Contribution to journalArticle

Open Access
499 Scopus citations

Transgene excision has no impact on in vivo integration of human iPS derived neural precursors

Major, T., Menon, J., Auyeung, G., Soldner, F., Hockemeyer, D., Jaenisch, R. & Tabar, V., Sep 22 2011, In : PloS one. 6, 9, e24687.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations
2010

Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells

Guenther, M. G., Frampton, G. M., Soldner, F., Hockemeyer, D., Mitalipova, M., Jaenisch, R. & Young, R. A., Aug 6 2010, In : Cell Stem Cell. 7, 2, p. 249-257 9 p.

Research output: Contribution to journalArticle

Open Access
314 Scopus citations

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats

Hargus, G., Cooper, O., Deleidi, M., Levy, A., Lee, K., Marlow, E., Yow, A., Soldner, F., Hockemeyer, D., Hallett, P. J., Osborn, T., Jaenisch, R. & Isacson, O., Sep 7 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 36, p. 15921-15926 6 p.

Research output: Contribution to journalArticle

Open Access
330 Scopus citations

Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

Hanna, J., Cheng, A. W., Saha, K., Kim, J., Lengner, C. J., Soldner, F., Cassady, J. P., Muffat, J., Carey, B. W. & Jaenisch, R., May 18 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 20, p. 9222-9227 6 p.

Research output: Contribution to journalArticle

585 Scopus citations
2009

Direct Reprogramming of Somatic Cells to a Pluripotent State

Hockemeyer, D., Soldner, F. & Jaenisch, R., Dec 1 2009, Essentials of Stem Cell Biology. Elsevier Inc., p. 29-31 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

Hockemeyer, D., Soldner, F., Beard, C., Gao, Q., Mitalipova, M., Dekelver, R. C., Katibah, G. E., Amora, R., Boydston, E. A., Zeitler, B., Meng, X., Miller, J. C., Zhang, L., Rebar, E. J., Gregory, P. D., Urnov, F. D. & Jaenisch, R., Sep 1 2009, In : Nature biotechnology. 27, 9, p. 851-857 7 p.

Research output: Contribution to journalArticle

735 Scopus citations

Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

Soldner, F., Hockemeyer, D., Beard, C., Gao, Q., Bell, G. W., Cook, E. G., Hargus, G., Blak, A., Cooper, O., Mitalipova, M., Isacson, O. & Jaenisch, R., Mar 6 2009, In : Cell. 136, 5, p. 964-977 14 p.

Research output: Contribution to journalArticle

Open Access
1145 Scopus citations

Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (DOI:10.1016/j.cell.2009.02.013)

Soldner, F., Hockemeyer, D., Beard, C., Gao, Q., Bell, G. W., Cook, E. G., Hargus, G., Blak, A., Cooper, O., Mitalipova, M., Isacson, O. & Jaenisch, R., Jun 26 2009, In : Cell. 137, 7, 1 p.

Research output: Contribution to journalComment/debate

Open Access
4 Scopus citations
2008

A Drug-Inducible System for Direct Reprogramming of Human Somatic Cells to Pluripotency

Hockemeyer, D., Soldner, F., Cook, E. G., Gao, Q., Mitalipova, M. & Jaenisch, R., Sep 11 2008, In : Cell Stem Cell. 3, 3, p. 346-353 8 p.

Research output: Contribution to journalArticle

Open Access
241 Scopus citations

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease

Wernig, M., Zhao, J. P., Pruszak, J., Hedlund, E., Fu, D., Soldner, F., Broccoli, V., Constantine-Paton, M., Isacson, O. & Jaenisch, R., Apr 15 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 15, p. 5856-5861 6 p.

Research output: Contribution to journalArticle

Open Access
943 Scopus citations
2007

Long-lasting regeneration after ischemia in the cerebral cortex

Leker, R. R., Soldner, F., Velasco, I., Gavin, D. K., Androutsellis-Theotokis, A. & McKay, R. D. G., Jan 1 2007, In : Stroke. 38, 1, p. 153-161 9 p.

Research output: Contribution to journalArticle

Open Access
156 Scopus citations
2006

Notch signalling regulates stem cell numbers in vitro and in vivo

Androutsellis-Theotokis, A., Leker, R. R., Soldner, F., Hoeppner, D. J., Ravin, R., Poser, S. W., Rueger, M. A., Bae, S. K., Kittappa, R. & McKay, R. D. G., Aug 17 2006, In : Nature. 442, 7104, p. 823-826 4 p.

Research output: Contribution to journalArticle

778 Scopus citations
2000

Effect of 1-methyl-4-phenylpyridinium on glutathione in rat pheochromocytoma PC 12 cells

Seyfried, J., Soldner, F., Kunz, W. S., Schulz, J. B., Klockgether, T., Kovar, K. A. & Wüllner, U., May 1 2000, In : Neurochemistry International. 36, 6, p. 489-497 9 p.

Research output: Contribution to journalArticle

40 Scopus citations
1999

Differential effects of L-buthionine sulfoximine and ethacrynic acid on glutathione levels and mitochondrial function in PC12 cells

Seyfried, J., Soldner, F., Schulz, J. B., Klockgether, T., Kovar, K. A. & Wüllner, U., Apr 2 1999, In : Neuroscience Letters. 264, 1-3, p. 1-4 4 p.

Research output: Contribution to journalArticle

66 Scopus citations

MPP+ inhibits proliferation of PC12 cells by a p21(WAF1/Cip1)-dependent pathway and induces cell death in cells lacking p21(WAF1/Cip1)

Soldner, F., Weller, M., Haid, S., Beinroth, S., Miller, S. W., Wüllner, U., Davis, R. E., Dichgans, J., Klockgether, T. & Schulz, J. B., Jul 10 1999, In : Experimental Cell Research. 250, 1, p. 75-85 11 p.

Research output: Contribution to journalArticle

45 Scopus citations