• 11734 Citations
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20002020

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2020

Multifaceted secretion of htNSC-derived hypothalamic islets induces survival and antidiabetic effect via peripheral implantation in mice

Tang, Y., Zuniga, J. P. H., Han, C., Yu, B. & Cai, D., Feb 2020, In : eLife. 9, e52580.

Research output: Contribution to journalArticle

Open Access

Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline

Xiao, Y. Z., Yang, M., Xiao, Y., Guo, Q., Huang, Y., Li, C. J., Cai, D. & Luo, X. H., Mar 3 2020, In : Cell metabolism. 31, 3, p. 534-548.e5

Research output: Contribution to journalArticle

7 Scopus citations

Regulation of muscle and metabolic physiology by hypothalamic erythropoietin independently of its peripheral action

Wang, Z., Khor, S. & Cai, D., Feb 2020, In : Molecular Metabolism. 32, p. 56-68 13 p.

Research output: Contribution to journalArticle

Open Access

Reversal of prolonged obesity-associated cerebrovascular dysfunction by inhibiting microglial Tak1

Shen, Q., Chen, Z., Zhao, F., Pan, S., Zhang, T., Cheng, X., Zhang, L., Zhang, S., Qi, J., Li, J., Cai, D. & Zhang, G., Jul 1 2020, In : Nature Neuroscience. 23, 7, p. 832-841 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Age-dependent decline of hypothalamic HIF2 in response to insulin and its contribution to advanced age-associated metabolic disorders in mice

Wang, Z., Khor, S. & Cai, D., Mar 29 2019, In : Journal of Biological Chemistry. 294, 13, p. 4946-4955 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

MiR199a-5p inhibits hepatic insulin sensitivity via suppression of ATG14-mediated autophagy article

Li, B., Wu, X., Chen, H., Zhuang, C., Zhang, Z., Yao, S., Cai, D., Ning, G. & Su, Q., Mar 1 2018, In : Cell Death and Disease. 9, 3, 405.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Astrocytic Process Plasticity and IKKβ/NF-κB in Central Control of Blood Glucose, Blood Pressure, and Body Weight

Zhang, Y., Reichel, J. M., Han, C., Zuniga-Hertz, J. P. & Cai, D., May 2 2017, In : Cell metabolism. 25, 5, p. 1091-1102.e4

Research output: Contribution to journalArticle

44 Scopus citations

Hypothalamic and inflammatory basis of hypertension

Khor, S. & Cai, D., 2017, In : Clinical Science. 131, 3, p. 211-223 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Hypothalamic stem cells control ageing speed partly through exosomal miRNAs

Zhang, Y., Kim, M. S., Jia, B., Yan, J., Zuniga-Hertz, J. P., Han, C. & Cai, D., Aug 3 2017, In : Nature. 548, 7665, p. 52-57 6 p.

Research output: Contribution to journalArticle

150 Scopus citations
4 Scopus citations

Obesity-associated extracellular mtDNA activates central TGFβ pathway to cause blood pressure increase

Alé, A., Zhang, Y., Han, C. & Cai, D., Jan 1 2017, In : American Journal of Physiology - Endocrinology and Metabolism. 312, 3, p. E161-E174

Research output: Contribution to journalArticle

7 Scopus citations
2016

Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress

Zhang, Z., Li, B., Meng, X., Yao, S., Jin, L., Yang, J., Wang, J., Zhang, H., Zhang, Z., Cai, D., Zhang, Y. & Ning, G., Feb 9 2016, In : Scientific reports. 6, 20848.

Research output: Contribution to journalArticle

42 Scopus citations

Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways

Song, T., Zheng, Y. M., Vincent, P. A., Cai, D., Rosenberg, P. & Wang, Y. X., Jan 1 2016, In : FASEB Journal. 30, 1, p. 214-229 16 p.

Research output: Contribution to journalArticle

12 Scopus citations

Central leptin and tumor necrosis factor-α (TNFα) in diurnal control of blood pressure and hypertension

Han, C., Wu, W., Ale, A., Kim, M. S. & Cai, D., Jul 15 2016, In : Journal of Biological Chemistry. 291, 29, p. 15131-15142 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
2015

Metabolic learning and memory formation by the brain influence systemic metabolic homeostasis

Zhang, Y., Liu, G., Yan, J., Zhang, Y., Li, B. & Cai, D., Apr 13 2015, In : Nature communications. 6, 6704.

Research output: Contribution to journalArticle

13 Scopus citations

Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis

Kim, M. S., Yan, J., Wu, W., Zhang, G., Zhang, Y. & Cai, D., May 28 2015, In : Nature Immunology. 16, 5, p. 525-533 9 p.

Research output: Contribution to journalArticle

25 Scopus citations
2014

Aberrant mir199a-5p/caveolin1/PPARα axis in hepatic steatosis

Li, B., Zhang, Z., Zhang, H., Quan, K., Lu, Y., Cai, D. & Ning, G., Oct 13 2014, In : Journal of Molecular Endocrinology. 53, 3, p. 393-403 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Control of obesity and glucose intolerance via building neural stem cells in the hypothalamus

Li, J., Tang, Y., Purkayastha, S., Yan, J. & Cai, D., Jun 2014, In : Molecular Metabolism. 3, 3, p. 313-324 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Obesity-and aging-induced excess of central transforming growth factor-β 2 potentiates diabetic development via an RNA stress response

Yan, J., Zhang, H., Yin, Y., Li, J., Tang, Y., Purkayastha, S., Li, L. & Cai, D., Sep 1 2014, In : Nature Medicine. 20, 9, p. 1001-1008 8 p.

Research output: Contribution to journalArticle

70 Scopus citations

Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα

Lu, Y., Liu, X., Jiao, Y., Xiong, X., Wang, E., Wang, X., Zhang, Z., Zhang, H., Pan, L., Guan, Y., Cai, D., Ning, G. & Li, X., Aug 1 2014, In : Journal of Clinical Investigation. 124, 8, p. 3501-3513 13 p.

Research output: Contribution to journalArticle

65 Scopus citations
2013

Counterbalance between BAG and URX neurons via guanylate cyclases controls lifespan homeostasis in C. elegans

Liu, T. & Cai, D., May 29 2013, In : EMBO Journal. 32, 11, p. 1529-1542 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Disruption of neurogenesis by hypothalamic inflammation in obesity or aging

Purkayastha, S. & Cai, D., Dec 2013, In : Reviews in Endocrine and Metabolic Disorders. 14, 4, p. 351-356 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

Zhang, G., Li, J., Purkayastha, S., Tang, Y., Zhang, H., Yin, Y., Li, B., Liu, G. & Cai, D., Jan 1 2013, In : Nature. 497, 7448, p. 211-216 6 p.

Research output: Contribution to journalArticle

445 Scopus citations

Sustained NF-κB Activation and Inhibition in β-Cells Have Minimal Effects on Function and Islet Transplant Outcomes

King, A. J. F., Guo, Y., Cai, D., Hollister-Lock, J., Morris, B., Salvatori, A., Corbett, J. A., Bonner-Weir, S., Shoelson, S. E. & Weir, G. C., Oct 18 2013, In : PloS one. 8, 10, e77452.

Research output: Contribution to journalArticle

7 Scopus citations

Treatment of Obesity and Diabetes Using Oxytocin or Analogs in Patients and Mouse Models

Zhang, H., Wu, C., Chen, Q., Chen, X., Xu, Z., Wu, J. & Cai, D., May 20 2013, In : PloS one. 8, 5, e61477.

Research output: Contribution to journalArticle

136 Scopus citations
2012

IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes

Li, J., Tang, Y. & Cai, D., Oct 2012, In : Nature Cell Biology. 14, 10, p. 999-1012 14 p.

Research output: Contribution to journalArticle

202 Scopus citations

Inflammatory cause of metabolic syndrome via brain stress and NF-κB

Cai, D. & Liu, T., Feb 2012, In : Aging. 4, 2, p. 98-115 18 p.

Research output: Contribution to journalArticle

120 Scopus citations

Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals

He, Z., Zhang, S. S., Meng, Q., Li, S., Zhu, H. H., Raquil, M. A., Alderson, N., Zhang, H., Wu, J., Rui, L., Cai, D. & Feng, G. S., May 1 2012, In : Molecular and cellular biology. 32, 10, p. 1867-1878 12 p.

Research output: Contribution to journalArticle

32 Scopus citations
2011
103 Scopus citations

Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IκB kinase β(IKKβ)/NF-κB pathway

Meng, Q. & Cai, D., Sep 16 2011, In : Journal of Biological Chemistry. 286, 37, p. 32324-32332 9 p.

Research output: Contribution to journalArticle

148 Scopus citations

Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation

Zhang, H., Zhang, G., Gonzalez, F. J., Park, S. M. & Cai, D., Jul 2011, In : PLoS biology. 9, 7, e1001112.

Research output: Contribution to journalArticle

67 Scopus citations

Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress

Purkayastha, S., Zhang, H., Zhang, G., Ahmed, Z., Wang, Y. & Cai, D., Feb 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 7, p. 2939-2944 6 p.

Research output: Contribution to journalArticle

115 Scopus citations

Neuropeptide Exocytosis Involving Synaptotagmin-4 and Oxytocin in Hypothalamic Programming of Body Weight and Energy Balance

Zhang, G., Bai, H., Zhang, H., Dean, C., Wu, Q., Li, J., Guariglia, S., Meng, Q. & Cai, D., Feb 10 2011, In : Neuron. 69, 3, p. 523-535 13 p.

Research output: Contribution to journalArticle

118 Scopus citations

Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-Π2 and NF-ΰB

Purkayastha, S., Zhang, G. & Cai, D., Jul 2011, In : Nature Medicine. 17, 7, p. 883-887 5 p.

Research output: Contribution to journalArticle

162 Scopus citations
2008

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H. & Cai, D., Oct 3 2008, In : Cell. 135, 1, p. 61-73 13 p.

Research output: Contribution to journalArticle

868 Scopus citations

Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes

Goldfine, A. B., Silver, R., Aldhahi, W., Cai, D., Tatro, E., Lee, J. & Shoelson, S. E., 2008, In : Clinical and Translational Science. 1, 1, p. 36-43 8 p.

Research output: Contribution to journalArticle

195 Scopus citations
2005

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J. & Shoelson, S. E., Feb 1 2005, In : Nature Medicine. 11, 2, p. 183-190 8 p.

Research output: Contribution to journalArticle

1566 Scopus citations

Regulation of IκB kinase and NF-κB in contracting adult rat skeletal muscle

Ho, R. C., Hirshman, M. F., Li, Y., Cai, D., Farmer, J. R., Aschenbach, W. G., Witczak, C. A., Shoelson, S. E. & Goodyear, L. J., Oct 1 2005, In : American Journal of Physiology - Cell Physiology. 289, 4 58-4, p. C794-C801

Research output: Contribution to journalArticle

93 Scopus citations
2004

IKKβ/NF-κB activation causes severe muscle wasting in mice

Cai, D., Frantz, J. D., Tawa, N. E., Melendez, P. A., Oh, B. C., Lidov, H. G. W., Hasselgren, P. O., Frontera, W. R., Lee, J., Glass, D. J. & Shoelson, S. E., Oct 15 2004, In : Cell. 119, 2, p. 285-298 14 p.

Research output: Contribution to journalArticle

917 Scopus citations
2003

Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5

Cai, D., Dhe-Paganon, S., Melendez, P. A., Lee, J. & Shoelson, S. E., Jul 11 2003, In : Journal of Biological Chemistry. 278, 28, p. 25323-25330 8 p.

Research output: Contribution to journalArticle

137 Scopus citations
2001
2000
17 Scopus citations