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Dongsheng Cai, Ph.D., M.D.

  • 10061 Citations
  • 27 h-Index
20002023
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  • 16 Similar Profiles
Obesity Medicine & Life Sciences
Overnutrition Medicine & Life Sciences
Hypothalamus Medicine & Life Sciences
Inflammation Medicine & Life Sciences
Brain Medicine & Life Sciences
Hypertension Medicine & Life Sciences
Pro-Opiomelanocortin Medicine & Life Sciences
Chemical activation Chemical Compounds

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Grants 2007 2023

Hypothalamic astrocyte-neuron relationship links overnutrition to hypertension

Cai, D.

National Institutes of Health

3/15/19 → 1/31/23

Project: Research project

Overnutrition
Astrocytes
Obesity
Hypertension
Neurons

Role of Hypothalamic IKK-beta/NF-kappaB in Nutritional Control of Aging

Cai, D.

National Institutes of Health

4/1/08 → 1/31/20

Project: Research project

I-kappa B Kinase
NF-kappa B
Hypothalamus
Caloric Restriction
Inflammation

Hypothalamic HIF in Nutrient Sensing and Metabolic Control

Cai, D.

National Institutes of Health

4/1/14 → 3/31/19

Project: Research project

Food
Diet
Obesity
Thermogenesis
Appetite

Hypothalamic IKK-beta in obesity-related hypertension

Cai, D.

National Institutes of Health

6/1/13 → 5/31/19

Project: Research project

I-kappa B Kinase
Pro-Opiomelanocortin
Obesity
Hypertension
Neurons

Role of IKK-beta/NF-kappaB in hypothalamic dysregulation of energy balance

Cai, D.

National Institutes of Health

7/1/07 → 4/30/19

Project: Research project

I-kappa B Kinase
NF-kappa B
Type 2 Diabetes Mellitus
Obesity
Overnutrition

Publications 2000 2019

  • 10061 Citations
  • 27 h-Index
  • 50 Article
  • 4 Comment/debate
  • 2 Review article
  • 1 Editorial

Age-dependent decline of hypothalamic HIF2 in response to insulin and its contribution to advanced age-associated metabolic disorders in mice

Wang, Z., Khor, S. & Cai, D., Jan 1 2019, In : Journal of Biological Chemistry. 294, 13, p. 4946-4955 10 p.

Research output: Contribution to journal › Article

Insulin
Pro-Opiomelanocortin
Weight Gain
Up-Regulation
endothelial PAS domain-containing protein 1

“Hypothalamic Microinflammation” Paradigm in Aging and Metabolic Diseases

Cai, D. & Khor, S., Jan 1 2019, In : Cell metabolism.

Research output: Contribution to journal › Review article

Metabolic Diseases
Hypothalamus
Inflammation
Disease Progression
Health

Erratum to: Hypothalamic stem cells control ageing speed partly through exosomal miRNAs (Nature, (2017), 548, 7665, (52-57), 10.1038/nature23282)

Zhang, Y., Kim, M. S., Jia, B., Yan, J., Zuniga-Hertz, J. P., Han, C. & Cai, D., Aug 23 2018, In : Nature. 560, 7719, p. E33

Research output: Contribution to journal › Comment/debate

Cell Aging
MicroRNAs
Stem Cells
Gene Expression
3 Citations (Scopus)

MiR199a-5p inhibits hepatic insulin sensitivity via suppression of ATG14-mediated autophagy article

Li, B., Wu, X., Chen, H., Zhuang, C., Zhang, Z., Yao, S., Cai, D., Ning, G. & Su, Q., Mar 1 2018, In : Cell Death and Disease. 9, 3, 405.

Research output: Contribution to journal › Article

Autophagy
Insulin Resistance
Liver
Hep G2 Cells
Adenoviridae
24 Citations (Scopus)

Astrocytic Process Plasticity and IKKβ/NF-κB in Central Control of Blood Glucose, Blood Pressure, and Body Weight

Zhang, Y., Reichel, J. M., Han, C., Zuniga-Hertz, J. P. & Cai, D., May 2 2017, In : Cell Metabolism. 25, 5, p. 1091-1102.e4

Research output: Contribution to journal › Article

Blood Glucose
Body Weight
Overnutrition
Blood Pressure
Astrocytes