• 4769 Citations
  • 41 h-Index
1995 …2022

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2019

Gastrointestinal defects in gallstone and cholecystectomized patients

Di Ciaula, A., Molina-Molina, E., Bonfrate, L., Wang, D. Q. H., Dumitrascu, D. L. & Portincasa, P., Mar 2019, In : European Journal of Clinical Investigation. 49, 3, e13066.

Research output: Contribution to journalArticle

2 Scopus citations

The physical presence of gallstone modulates ex vivo cholesterol crystallization pathways of human bile

Portincasa, P., Van Erpecum, K. J., Di Ciaula, A. & Wang, D. Q. H., Feb 1 2019, In : Gastroenterology Report. 7, 1, p. 32-41 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The Role of Diet in the Pathogenesis of Cholesterol Gallstones

Di Ciaula, A., Garruti, G., Frühbeck, G., De Angelis, M., de Bari, O., Wang, D. Q. H., Lammert, F. & Portincasa, P., Jan 1 2019, In : Current medicinal chemistry. 26, 19, p. 3620-3638 19 p.

Research output: Contribution to journalArticle

4 Scopus citations

Update on the Molecular Mechanisms Underlying the Effect of Cholecystokinin and Cholecystokinin-1 Receptor on the Formation of Cholesterol Gallstones

Wang, H. H., Portincasa, P. & Wang, D. Q. H., Jan 1 2019, In : Current medicinal chemistry. 26, 19, p. 3407-3423 17 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Cholecystectomy and risk of metabolic syndrome

Di Ciaula, A., Garruti, G., Wang, D. Q. H. & Portincasa, P., Jan 1 2018, (Accepted/In press) In : European Journal of Internal Medicine.

Research output: Contribution to journalArticle

9 Scopus citations

Cholesterol cholelithiasis: part of a systemic metabolic disease, prone to primary prevention

Di Ciaula, A., Wang, D. Q. H. & Portincasa, P., Jan 1 2018, (Accepted/In press) In : Expert Review of Gastroenterology and Hepatology.

Research output: Contribution to journalArticle

4 Scopus citations

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Giorgi, C., Marchi, S., Simoes, I. C. M., Ren, Z., Morciano, G., Perrone, M., Patalas-Krawczyk, P., Borchard, S., Jędrak, P., Pierzynowska, K., Szymański, J., Wang, D. Q., Portincasa, P., Węgrzyn, G., Zischka, H., Dobrzyn, P., Bonora, M., Duszynski, J., Rimessi, A., Karkucinska-Wieckowska, A. & 7 others, Dobrzyn, A., Szabadkai, G., Zavan, B., Oliveira, P. J., Sardao, V. A., Pinton, P. & Wieckowski, M. R., Jan 1 2018, In : International Review of Cell and Molecular Biology. 340, p. 209-344 136 p.

Research output: Contribution to journalArticle

14 Scopus citations

Silencing steroid receptor coactivator-1 in the nucleus of the solitary tract reduces estrogenic effects on feeding and apolipoprotein A-IV expression

Shen, L., Liu, Y., Tso, P., Wang, D. Q. H., Sean Davidson, W., Woods, S. C. & Liu, M., Jan 1 2018, In : Journal of Biological Chemistry. 293, 6, p. 2091-2101 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

BDNF/TrkB signaling mediates the anorectic action of estradiol in the nucleus tractus solitarius

Shen, L., Wang, D. Q. H., Xu, M., Woods, S. C. & Liu, M., Jan 1 2017, In : Oncotarget. 8, 48, p. 84028-84038 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Bile acid physiology

Di Ciaula, A., Garruti, G., Baccetto, R. L., Molina-Molina, E., Bonfrate, L., Wang, D. Q. H. & Portincasa, P., Nov 2017, In : Annals of Hepatology. 16, p. s4-s14

Research output: Contribution to journalArticle

34 Scopus citations

Bile acids and cancer: Direct and environmental-dependent effects

Di Ciaula, A., Wang, D. Q. H., Molina, E. M., Baccetto, R. L., Calamita, G., Palmieri, V. O. & Portincasa, P., Nov 1 2017, In : Annals of Hepatology. 16, p. S87-S105

Research output: Contribution to journalArticle

7 Scopus citations

Cholesterol and lipoprotein metabolism and atherosclerosis: Recent advances in reverse cholesterol transport

Wang, H. H., Garruti, G., Liu, M., Portincasa, P. & Wang, D. Q. H., Nov 1 2017, In : Annals of Hepatology. 16, p. s27-s42

Research output: Contribution to journalArticle

26 Scopus citations

Cross-talk between bile acids and gastro-intestinal and thermogenic hormones: Clues from bariatric surgery

Garruti, G., Di Ciaula, A., Wang, H. H., Wang, D. Q. H. & Portincasa, P., Jan 1 2017, In : Annals of Hepatology. 16, p. s68-s82

Research output: Contribution to journalArticle

3 Scopus citations

Effect of inhibition of iIntestinal cholesterol absorption on the prevention of cholesterol gallstone formation

Portincasa, P. & Wang, D. Q. H., Aug 1 2017, In : Medicinal Chemistry. 13, 5, p. 421-429 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Evidence that the adenosine triphosphate-binding cassette G5/G8-independent pathway plays a determinant role in cholesterol gallstone formation in mice

Wang, H. H., Li, X., Patel, S. B. & Wang, D. Q. H., Jan 1 2016, In : Hepatology. 64, 3, p. 853-864 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Lack of endogenous cholecystokinin promotes cholelithogenesis in mice

Wang, H. H., Liu, M., Portincasa, P., Tso, P. & Wang, D. Q. H., Mar 1 2016, In : Neurogastroenterology and Motility. 28, 3, p. 364-375 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells

Vecchione, G., Grasselli, E., Voci, A., Baldini, F., Grattagliano, I., Wang, D. Q., Portincasa, P. & Vergani, L., Jul 14 2016, In : World Journal of Gastroenterology. 22, 26, p. 6016-6026 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

The cholecystokinin-1 receptor antagonist devazepide increases cholesterol cholelithogenesis in mice

Wang, H. H., Portincasa, P. & Wang, D. Q. H., Feb 1 2016, In : European Journal of Clinical Investigation. 46, 2, p. 158-169 12 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

A novel therapeutic effect of statins on nephrogenic diabetes insipidus

Bonfrate, L., Procino, G., Wang, D. Q. H., Svelto, M. & Portincasa, P., Feb 1 2015, In : Journal of Cellular and Molecular Medicine. 19, 2, p. 265-282 18 p.

Research output: Contribution to journalArticle

17 Scopus citations

Apolipoprotein A-V is present in bile and its secretion increases with lipid absorption in Sprague-Dawley rats

Zhang, L. S., Sato, H., Yang, Q., Ryan, R. O., Wang, D. Q. H., Howles, P. N. & Tso, P., Jan 1 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 11, p. G918-G925

Research output: Contribution to journalArticle

5 Scopus citations

Endogenous elevation of plasma cholecystokinin does not prevent gallstones

Shahid, R. A., Wang, D. Q. H., Fee, B. E., Mccall, S. J., Romac, J. M. J., Vigna, S. R. & Liddle, R. A., Mar 1 2015, In : European Journal of Clinical Investigation. 45, 3, p. 237-246 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Estrogen induces two distinct cholesterol crystallization pathways by activating ERα and GPR30 in female mice

De Bari, O., Wang, T. Y., Liu, M., Portincasa, P. & Wang, D. Q. H., Sep 1 2015, In : Journal of Lipid Research. 56, 9, p. 1691-1700 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ginsenoside Rb1 increases insulin sensitivity by activating AMP-activated protein kinase in male rats

Shen, L., Haas, M., Wang, D. Q. H., May, A., Lo, C. C., Obici, S., Tso, P., Woods, S. C. & Liu, M., Jan 1 2015, In : Physiological Reports. 3, 9, e12543.

Research output: Contribution to journalArticle

20 Scopus citations

Gut vagal afferents are necessary for the eating-suppressive effect of intraperitoneally administered ginsenoside Rb1 in rats

Shen, L., Wang, D. Q. H., Lo, C. C., Arnold, M., Tso, P., Woods, S. C. & Liu, M., Dec 1 2015, In : Physiology and Behavior. 152, p. 62-67 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

The deletion of the estrogen receptor α gene reduces susceptibility to estrogen-induced cholesterol cholelithiasis in female mice

de Bari, O., Wang, H. H., Portincasa, P., Liu, M. & Wang, D. Q. H., Oct 1 2015, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1852, 10, p. 2161-2169 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Cholesterol cholelithiasis in pregnant women: Pathogenesis, prevention and treatment

de Bari, O., Wang, T. Y., Liu, M., Paik, C. N., Portincasa, P. & Wang, D. Q. H., Nov 1 2014, In : Annals of Hepatology. 13, 6, p. 728-745 18 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Estradiol stimulates apolipoprotein A-IV gene expression in the nucleus of the solitary tract through estrogen receptor-α

Shen, L., Liu, Y., Wang, D. Q. H., Tso, P., Woods, S. C. & Liu, M., Oct 1 2014, In : Endocrinology. 155, 10, p. 3882-3890 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Ezetimibe prevents the formation of oestrogen-induced cholesterol gallstones in mice

de Bari, O., Wang, H. H., Portincasa, P., Paik, C. N., Liu, M. & Wang, D. Q. H., Dec 1 2014, In : European Journal of Clinical Investigation. 44, 12, p. 1159-1168 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pathogenic role of oxidative and nitrosative stress in primary biliary cirrhosis

Grattagliano, I., Calamita, G., Cocco, T., Wang, D. Q. H. & Portincasa, P., Jan 1 2014, In : World Journal of Gastroenterology. 20, 19, p. 5746-5759 14 p.

Research output: Contribution to journalArticle

17 Scopus citations
2013

A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes

Grattagliano, I., Diogo, C. V., Mastrodonato, M., de Bari, O., Persichella, M., Wang, D. Q. H., Liquori, A., Ferri, D., Carratù, M. R., Oliveira, P. J. & Portincasa, P., May 31 2013, In : World Journal of Gastroenterology. 19, 20, p. 3007-3017 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Excess cholesterol and fat in the diet: A dangerous liaison for energy expenditure and the liver

Neuschwander-Tetri, B. A. & Wang, D. Q. H., Jan 1 2013, In : Hepatology. 57, 1, p. 7-9 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats

Shen, L., Xiong, Y., Wang, D. Q. H., Howles, P., Basford, J. E., Wang, J., Xiong, Y. Q., Hui, D. Y., Woods, S. C. & Liu, M., May 1 2013, In : Journal of Lipid Research. 54, 5, p. 1430-1438 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Steatosis in the Liver

Wang, D. Q. H., Portincasa, P. & Neuschwander-Tetri, B. A., Dec 1 2013, In : Comprehensive Physiology. 3, 4, p. 1493-1532 40 p.

Research output: Contribution to journalArticle

23 Scopus citations
2012

Gallbladder and gastric motility in obese newborns, pre-adolescents and adults

Di Ciaula, A., Wang, D. Q. H. & Portincasa, P., Aug 2012, In : Journal of Gastroenterology and Hepatology (Australia). 27, 8, p. 1298-1305 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Isolation and primary culture of rat hepatic cells

Shen, L., Hillebrand, A., Wang, D. Q. H. & Liu, M., Jun 29 2012, In : Journal of Visualized Experiments. 64, e3917.

Research output: Contribution to journalArticle

63 Scopus citations

miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity

Allen, R. M., Marquart, T. J., Albert, C. J., Suchy, F. J., Wang, D. Q. H., Ananthanarayanan, M., Ford, D. A. & Baldán, Á., Sep 1 2012, In : EMBO Molecular Medicine. 4, 9, p. 882-895 14 p.

Research output: Contribution to journalArticle

116 Scopus citations
2011

Apolipoprotein E reduces food intake via PI3K/Akt signaling pathway in the hypothalamus

Shen, L., Wang, D. Q. H., Tso, P., Jandacek, R. J., Woods, S. C. & Liu, M., Nov 30 2011, In : Physiology and Behavior. 105, 1, p. 124-128 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Dissecting the genetic heterogeneity of gallbladder stone formation

Krawczyk, M., Wang, D. Q. H., Portincasa, P. & Lammert, F., May 9 2011, In : Seminars in liver disease. 31, 2, p. 157-172 16 p.

Research output: Contribution to journalArticle

47 Scopus citations

Mitochondria in chronic liver disease

Grattagliano, I., Russmann, S., Diogo, C., Bonfrate, L., Oliveira, P. J., Wang, D. Q. H. & Portincasa, P., Jun 1 2011, In : Current drug targets. 12, 6, p. 879-893 15 p.

Research output: Contribution to journalArticle

46 Scopus citations
2010

Diet-induced lipid accumulation in phospholipid transfer protein-deficient mice: Its atherogenicity and potential mechanism

Yeang, C., Qin, S., Chen, K., Wang, D. Q. H. & Jiang, X. C., Oct 1 2010, In : Journal of Lipid Research. 51, 10, p. 2993-3002 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effect of ezetimibe on incretin secretion in response to the intestinal absorption of a mixed meal

Yang, L., Li, X., Ji, Y., Kohan, A. B., Wang, D. Q. H., Howles, P. N., Hui, D. Y., Lai, J. & Tso, P., Nov 1 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 299, 5, p. G1003-G1011

Research output: Contribution to journalArticle

7 Scopus citations

Effect of gallbladder hypomotility on cholesterol crystallization and growth in CCK-deficient mice

Wang, H. H., Portincasa, P., Liu, M., Tso, P., Samuelson, L. C. & Wang, D. Q. H., Feb 1 2010, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1801, 2, p. 138-146 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Estradiol increases the anorectic effect of central apolipoprotein A-IV

Shen, L., Wang, D. Q. H., Lo, C. M., Tso, P., Davidson, W. S., Woods, S. C. & Liu, M., Jul 1 2010, In : Endocrinology. 151, 7, p. 3163-3168 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Transgenic overexpression of Abcb11 enhances biliary bile salt outputs, but does not affect cholesterol cholelithogenesis in mice

Wang, H. H., Lammert, F., Schmitz, A. & Wang, D. Q. H., Jun 1 2010, In : European Journal of Clinical Investigation. 40, 6, p. 541-551 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
2009

Biliary proteins and their redox status changes in gallstone patients: Relation to stone composition and cholesterol crystallization

Grattagliano, I., Wang, D. Q. H., Di Ciaula, A., Diogo, C. V., Palasciano, G. & Portincasa, P., Nov 1 2009, In : European Journal of Clinical Investigation. 39, 11, p. 986-992 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Food-entrained rhythmic expression of apolipoprotein E expression in the hypothalamus of rats

Shen, L., Carey, K., Wang, D. Q. H., Woods, S. C. & Liu, M., Jun 1 2009, In : Brain research. 1273, p. 66-71 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats

Shen, L., Tso, P., Wang, D. Q. H., Woods, S. C., Davidson, W. S., Sakai, R. & Liu, M., Aug 4 2009, In : Physiology and Behavior. 98, 1-2, p. 223-228 6 p.

Research output: Contribution to journalArticle

19 Scopus citations
2008

Beneficial effects of oral tilactase on patients with hypolactasia

Portincasa, P., Di Ciaula, A., Vacca, M., Montelli, R., Wang, D. Q. H. & Palasciano, G., Nov 1 2008, In : European Journal of Clinical Investigation. 38, 11, p. 835-844 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Effect of Ezetimibe on the Prevention and Dissolution of Cholesterol Gallstones

Wang, H. H., Portincasa, P., Mendez-Sanchez, N., Uribe, M. & Wang, D. Q. H., Jun 2008, In : Gastroenterology. 134, 7, p. 2101-2110 10 p.

Research output: Contribution to journalArticle

110 Scopus citations

Gastrointestinal symptoms and motility disorders in patients with systemic scleroderma

Di Ciaula, A., Covelli, M., Berardino, M., Wang, D. Q. H., Lapadula, G., Palasciano, G. & Portincasa, P., Apr 9 2008, In : BMC Gastroenterology. 8, 7.

Research output: Contribution to journalArticle

34 Scopus citations