• 4847 Citations
  • 42 h-Index
19952020

Research output per year

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Publications

2020

A novel GPER antagonist protects against the formation of estrogen-induced cholesterol gallstones in female mice

DeLeon, C., Wang, H. H., Gunn, J., Wilhelm, M., Cole, A., Arnett, S., Wang, D. Q. H. & Arnatt, C. K., May 1 2020, In : Journal of Lipid Research. 61, 5, p. 767-777 11 p.

Research output: Contribution to journalArticle

Novel insights in health-promoting properties of sweet cherries

Faienza, M. F., Corbo, F., Carocci, A., Catalano, A., Clodoveo, M. L., Grano, M., Wang, D. Q. H., D'Amato, G., Muraglia, M., Franchini, C., Brunetti, G. & Portincasa, P., Jun 2020, In : Journal of Functional Foods. 69, 103945.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Novel insights into the pathogenesis and management of the metabolic syndrome

Wang, H. H., Lee, D. K., Liu, M., Portincasa, P. & Wang, D. Q. H., May 1 2020, In : Pediatric Gastroenterology, Hepatology and Nutrition. 23, 3, 189.

Research output: Contribution to journalArticle

Open Access

Physical activity modulating lipid metabolism in gallbladder diseases

Shanmugam, H., Molina-Molina, E., Di Palo, D. M., Faienza, M. F., Di Ciaula, A., Garruti, G., Wang, D. Q. H. & Portincasa, P., Mar 2020, In : Journal of Gastrointestinal and Liver Diseases. 29, 1, p. 99-110 12 p.

Research output: Contribution to journalReview article

Open Access
2019

Gastrointestinal defects in gallstone and cholecystectomized patients

Di Ciaula, A., Molina-Molina, E., Bonfrate, L., Wang, D. Q. H., Dumitrascu, D. L. & Portincasa, P., Mar 2019, In : European Journal of Clinical Investigation. 49, 3, e13066.

Research output: Contribution to journalArticle

3 Scopus citations

Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease

Grattagliano, I., Montezinho, L. P., Oliveira, P. J., Frühbeck, G., Gómez-Ambrosi, J., Montecucco, F., Carbone, F., Wieckowski, M. R., Wang, D. Q. H. & Portincasa, P., Feb 2019, In : Biochemical Pharmacology. 160, p. 34-45 12 p.

Research output: Contribution to journalReview article

7 Scopus citations

The physical presence of gallstone modulates ex vivo cholesterol crystallization pathways of human bile

Portincasa, P., Van Erpecum, K. J., Di Ciaula, A. & Wang, D. Q. H., Feb 1 2019, In : Gastroenterology Report. 7, 1, p. 32-41 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The Role of Diet in the Pathogenesis of Cholesterol Gallstones

Di Ciaula, A., Garruti, G., Frühbeck, G., De Angelis, M., de Bari, O., Wang, D. Q. H., Lammert, F. & Portincasa, P., Jan 1 2019, In : Current medicinal chemistry. 26, 19, p. 3620-3638 19 p.

Research output: Contribution to journalArticle

4 Scopus citations

Update on the Molecular Mechanisms Underlying the Effect of Cholecystokinin and Cholecystokinin-1 Receptor on the Formation of Cholesterol Gallstones

Wang, H. H., Portincasa, P. & Wang, D. Q. H., Jan 1 2019, In : Current medicinal chemistry. 26, 19, p. 3407-3423 17 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

An update on the pathogenesis of cholesterol gallstone disease

Di Ciaula, A., Wang, D. Q. H. & Portincasa, P., Mar 1 2018, In : Current Opinion in Gastroenterology. 34, 2, p. 71-80 10 p.

Research output: Contribution to journalReview article

21 Scopus citations

Cholecystectomy: A way forward and back to metabolic syndrome?

Garruti, G., Wang, D. Q. H., Di Ciaula, A. & Portincasa, P., Jan 1 2018, In : Laboratory Investigation. 98, 1, p. 4-6 3 p.

Research output: Contribution to journalReview article

9 Scopus citations

Cholecystectomy and risk of metabolic syndrome

Di Ciaula, A., Garruti, G., Wang, D. Q. H. & Portincasa, P., Jan 1 2018, (Accepted/In press) In : European Journal of Internal Medicine.

Research output: Contribution to journalArticle

9 Scopus citations

Cholesterol cholelithiasis: part of a systemic metabolic disease, prone to primary prevention

Di Ciaula, A., Wang, D. Q. H. & Portincasa, P., Jan 1 2018, (Accepted/In press) In : Expert Review of Gastroenterology and Hepatology.

Research output: Contribution to journalArticle

4 Scopus citations

Exercising the hepatobiliary-gut axis. The impact of physical activity performance

Molina-Molina, E., Lunardi Baccetto, R., Wang, D. Q. H., de Bari, O., Krawczyk, M. & Portincasa, P., Aug 2018, In : European Journal of Clinical Investigation. 48, 8, e12958.

Research output: Contribution to journalReview article

16 Scopus citations

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Giorgi, C., Marchi, S., Simoes, I. C. M., Ren, Z., Morciano, G., Perrone, M., Patalas-Krawczyk, P., Borchard, S., Jędrak, P., Pierzynowska, K., Szymański, J., Wang, D. Q., Portincasa, P., Węgrzyn, G., Zischka, H., Dobrzyn, P., Bonora, M., Duszynski, J., Rimessi, A., Karkucinska-Wieckowska, A. & 7 others, Dobrzyn, A., Szabadkai, G., Zavan, B., Oliveira, P. J., Sardao, V. A., Pinton, P. & Wieckowski, M. R., Jan 1 2018, In : International Review of Cell and Molecular Biology. 340, p. 209-344 136 p.

Research output: Contribution to journalArticle

19 Scopus citations

Mitochondria in liver diseases

Grattagliano, I., de Bari, O., Di Palo, D., Montecucco, F., Carbone, F., Oliveira, P. J., Wang, D. Q. H. & Portincasa, P., Mar 21 2018, Mitochondrial Biology and Experimental Therapeutics. Springer International Publishing, p. 91-126 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Mouse models of gallstone disease

Wang, T. Y., Portincasa, P., Liu, M., Tso, P. & Wang, D. Q. H., Mar 1 2018, In : Current Opinion in Gastroenterology. 34, 2, p. 59-70 12 p.

Research output: Contribution to journalReview article

7 Scopus citations

Silencing steroid receptor coactivator-1 in the nucleus of the solitary tract reduces estrogenic effects on feeding and apolipoprotein A-IV expression

Shen, L., Liu, Y., Tso, P., Wang, D. Q. H., Sean Davidson, W., Woods, S. C. & Liu, M., Jan 1 2018, In : Journal of Biological Chemistry. 293, 6, p. 2091-2101 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Similarities and differences between biliary sludge and microlithiasis: Their clinical and pathophysiological significances

Wang, H. H., Portincasa, P., Liu, M., Tso, P. & Wang, D. Q. H., Dec 2018, In : Liver Research. 2, 4, p. 186-199 14 p.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations
2017

BDNF/TrkB signaling mediates the anorectic action of estradiol in the nucleus tractus solitarius

Shen, L., Wang, D. Q. H., Xu, M., Woods, S. C. & Liu, M., Jan 1 2017, In : Oncotarget. 8, 48, p. 84028-84038 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Bile acid physiology

Di Ciaula, A., Garruti, G., Baccetto, R. L., Molina-Molina, E., Bonfrate, L., Wang, D. Q. H. & Portincasa, P., Nov 2017, In : Annals of Hepatology. 16, p. s4-s14

Research output: Contribution to journalArticle

37 Scopus citations

Bile acids and cancer: Direct and environmental-dependent effects

Di Ciaula, A., Wang, D. Q. H., Molina, E. M., Baccetto, R. L., Calamita, G., Palmieri, V. O. & Portincasa, P., Nov 1 2017, In : Annals of Hepatology. 16, p. S87-S105

Research output: Contribution to journalArticle

7 Scopus citations

Cholesterol and lipoprotein metabolism and atherosclerosis: Recent advances in reverse cholesterol transport

Wang, H. H., Garruti, G., Liu, M., Portincasa, P. & Wang, D. Q. H., Nov 1 2017, In : Annals of Hepatology. 16, p. s27-s42

Research output: Contribution to journalArticle

29 Scopus citations

Cross-talk between bile acids and gastro-intestinal and thermogenic hormones: Clues from bariatric surgery

Garruti, G., Di Ciaula, A., Wang, H. H., Wang, D. Q. H. & Portincasa, P., Jan 1 2017, In : Annals of Hepatology. 16, p. s68-s82

Research output: Contribution to journalArticle

3 Scopus citations

Effect of inhibition of iIntestinal cholesterol absorption on the prevention of cholesterol gallstone formation

Portincasa, P. & Wang, D. Q. H., Aug 1 2017, In : Medicinal Chemistry. 13, 5, p. 421-429 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Impaired intestinal cholecystokinin secretion, a fascinating but overlooked link between coeliac disease and cholesterol gallstone disease

Wang, H. H., Liu, M., Li, X., Portincasa, P. & Wang, D. Q. H., Apr 1 2017, In : European Journal of Clinical Investigation. 47, 4, p. 328-333 6 p.

Research output: Contribution to journalReview article

1 Scopus citations

New insights into the role of Lith genes in the formation of cholesterol-supersaturated bile

Wang, H. H., Li, T., Portincasa, P., Ford, D. A., Neuschwander-Tetri, B. A., Tso, P. & Wang, D. Q. H., Jun 2017, In : Liver Research. 1, 1, p. 42-53 12 p.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Transintestinal cholesterol excretion: A secondary, nonbiliary pathway contributing to reverse cholesterol transport

Wang, D. Q. H., Portincasa, P. & Tso, P., Oct 1 2017, In : Hepatology. 66, 4, p. 1337-1340 4 p.

Research output: Contribution to journalComment/debate

6 Scopus citations
2016

Evidence that the adenosine triphosphate-binding cassette G5/G8-independent pathway plays a determinant role in cholesterol gallstone formation in mice

Wang, H. H., Li, X., Patel, S. B. & Wang, D. Q. H., Jan 1 2016, In : Hepatology. 64, 3, p. 853-864 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Gallstones

Lammert, F., Gurusamy, K., Ko, C. W., Miquel, J. F., Méndez-Sánchez, N., Portincasa, P., Van Erpecum, K. J., Van Laarhoven, C. J. & Wang, D. Q. H., Apr 28 2016, In : Nature Reviews Disease Primers. 2, 16024.

Research output: Contribution to journalArticle

71 Scopus citations

Lack of endogenous cholecystokinin promotes cholelithogenesis in mice

Wang, H. H., Liu, M., Portincasa, P., Tso, P. & Wang, D. Q. H., Mar 1 2016, In : Neurogastroenterology and Motility. 28, 3, p. 364-375 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Management of gallstones and its related complications

Portincasa, P., Di Ciaula, A., De Bari, O., Garruti, G., Palmieri, V. O. & Wang, D. Q. H., Jan 1 2016, In : Expert Review of Gastroenterology and Hepatology. 10, 1, p. 93-112 20 p.

Research output: Contribution to journalReview article

21 Scopus citations

New Exploration of Chinese Herbal Medicines in Hepatology

Feng, Y., Yuen, M. F., Xu, Q., Wen, X. Y. & Wang, D. Q. H., 2016, In : Evidence-based Complementary and Alternative Medicine. 2016, 3056438.

Research output: Contribution to journalReview article

1 Scopus citations

Silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells

Vecchione, G., Grasselli, E., Voci, A., Baldini, F., Grattagliano, I., Wang, D. Q., Portincasa, P. & Vergani, L., Jul 14 2016, In : World Journal of Gastroenterology. 22, 26, p. 6016-6026 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

The cholecystokinin-1 receptor antagonist devazepide increases cholesterol cholelithogenesis in mice

Wang, H. H., Portincasa, P. & Wang, D. Q. H., Feb 1 2016, In : European Journal of Clinical Investigation. 46, 2, p. 158-169 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

The dangerous link between childhood and adulthood predictors of obesity and metabolic syndrome

Faienza, M. F., Wang, D. Q. H., Frühbeck, G., Garruti, G. & Portincasa, P., Mar 1 2016, In : Internal and Emergency Medicine. 11, 2, p. 175-182 8 p.

Research output: Contribution to journalReview article

46 Scopus citations
2015

A novel therapeutic effect of statins on nephrogenic diabetes insipidus

Bonfrate, L., Procino, G., Wang, D. Q. H., Svelto, M. & Portincasa, P., Feb 1 2015, In : Journal of Cellular and Molecular Medicine. 19, 2, p. 265-282 18 p.

Research output: Contribution to journalArticle

18 Scopus citations

Apolipoprotein A-V is present in bile and its secretion increases with lipid absorption in Sprague-Dawley rats

Zhang, L. S., Sato, H., Yang, Q., Ryan, R. O., Wang, D. Q. H., Howles, P. N. & Tso, P., Jan 1 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 11, p. G918-G925

Research output: Contribution to journalArticle

5 Scopus citations

Endogenous elevation of plasma cholecystokinin does not prevent gallstones

Shahid, R. A., Wang, D. Q. H., Fee, B. E., Mccall, S. J., Romac, J. M. J., Vigna, S. R. & Liddle, R. A., Mar 1 2015, In : European Journal of Clinical Investigation. 45, 3, p. 237-246 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Estrogen induces two distinct cholesterol crystallization pathways by activating ERα and GPR30 in female mice

De Bari, O., Wang, T. Y., Liu, M., Portincasa, P. & Wang, D. Q. H., Sep 1 2015, In : Journal of Lipid Research. 56, 9, p. 1691-1700 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Ginsenoside Rb1 increases insulin sensitivity by activating AMP-activated protein kinase in male rats

Shen, L., Haas, M., Wang, D. Q. H., May, A., Lo, C. C., Obici, S., Tso, P., Woods, S. C. & Liu, M., Jan 1 2015, In : Physiological Reports. 3, 9, e12543.

Research output: Contribution to journalArticle

20 Scopus citations

Gut vagal afferents are necessary for the eating-suppressive effect of intraperitoneally administered ginsenoside Rb1 in rats

Shen, L., Wang, D. Q. H., Lo, C. C., Arnold, M., Tso, P., Woods, S. C. & Liu, M., Dec 1 2015, In : Physiology and Behavior. 152, p. 62-67 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

The deletion of the estrogen receptor α gene reduces susceptibility to estrogen-induced cholesterol cholelithiasis in female mice

de Bari, O., Wang, H. H., Portincasa, P., Liu, M. & Wang, D. Q. H., Oct 1 2015, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1852, 10, p. 2161-2169 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Cholesterol cholelithiasis in pregnant women: Pathogenesis, prevention and treatment

de Bari, O., Wang, T. Y., Liu, M., Paik, C. N., Portincasa, P. & Wang, D. Q. H., Nov 1 2014, In : Annals of Hepatology. 13, 6, p. 728-745 18 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Estradiol stimulates apolipoprotein A-IV gene expression in the nucleus of the solitary tract through estrogen receptor-α

Shen, L., Liu, Y., Wang, D. Q. H., Tso, P., Woods, S. C. & Liu, M., Oct 1 2014, In : Endocrinology. 155, 10, p. 3882-3890 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Ezetimibe prevents the formation of oestrogen-induced cholesterol gallstones in mice

de Bari, O., Wang, H. H., Portincasa, P., Paik, C. N., Liu, M. & Wang, D. Q. H., Dec 1 2014, In : European Journal of Clinical Investigation. 44, 12, p. 1159-1168 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Obesity and the risk and prognosis of gallstone disease and pancreatitis

Bonfrate, L., Wang, D. Q. H., Garruti, G. & Portincasa, P., Jan 1 2014, In : Best Practice and Research: Clinical Gastroenterology. 28, 4, p. 623-635 13 p.

Research output: Contribution to journalReview article

51 Scopus citations

Pathogenic role of oxidative and nitrosative stress in primary biliary cirrhosis

Grattagliano, I., Calamita, G., Cocco, T., Wang, D. Q. H. & Portincasa, P., Jan 1 2014, In : World Journal of Gastroenterology. 20, 19, p. 5746-5759 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Therapeutic reflections in cholesterol homeostasis and gallstone disease: A review

Di Ciaula, A., Wang, D. Q. H., Garruti, G., Wang, H. H., Grattagliano, I., De Bari, O. & Portincasa, P., Apr 2014, In : Current medicinal chemistry. 21, 12, p. 1435-1447 13 p.

Research output: Contribution to journalReview article

15 Scopus citations
30 Scopus citations