• 3486 Citations
  • 28 h-Index
1987 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Publications

  • 3486 Citations
  • 28 h-Index
  • 35 Article
  • 4 Short survey
  • 4 Review article
  • 1 Comment/debate
2020

Are all splicing mutations the same?

Bowman, T. V. & Query, C. C., Mar 26 2020, In : Blood. 135, 13, p. 978-979 2 p.

Research output: Contribution to journalReview article

Open Access

Prp5-Spt8/Spt3 interaction mediates a reciprocal coupling between splicing and transcription

Shao, W., Ding, Z., Zheng, Z. Z., Shen, J. J., Shen, Y. X., Pu, J., Fan, Y. J., Query, C. C. & Xu, Y. Z., Jun 19 2020, In : Nucleic acids research. 48, 11, p. 5799-5813 15 p.

Research output: Contribution to journalArticle

Open Access
2016

Pseudouridines in U2 snRNA stimulate the ATPase activity of Prp5 during spliceosome assembly

Wu, G., Adachi, H., Ge, J., Stephenson, D., Query, C. C. & Yu, Y. T., Mar 15 2016, In : EMBO Journal. 35, 6, p. 654-667 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing

Tang, Q., Rodriguez-Santiago, S., Wang, J., Pu, J., Yuste, A., Gupta, V., Moldón, A., Xu, Y. Z. & Query, C. C., Dec 15 2016, In : Genes and Development. 30, 24, p. 2710-2723 14 p.

Research output: Contribution to journalArticle

33 Scopus citations

Structural biology: Catalytic spliceosome captured

Kosmyna, B. & Query, C. C., Aug 10 2016, In : Nature. 537, 7619, p. 175-176 2 p.

Research output: Contribution to journalShort survey

1 Scopus citations
2014

A pseudouridine residue in the spliceosome core is part of the filamentous growth program in yeast

Basak, A. & Query, C. C., Aug 21 2014, In : Cell Reports. 8, 4, p. 966-973 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Endogenous U2•U5•U6 snRNA complexes in S. pombe are intron lariat spliceosomes

Chen, W., Shulha, H. P., Ashar-Patel, A., Yan, J., Green, K. M., Query, C. C., Rhind, N., Weng, Z. & Moore, M. J., Mar 1 2014, In : RNA. 20, 3, p. 308-320 13 p.

Research output: Contribution to journalArticle

25 Scopus citations
2013

Splicing proofreading at 5′ splice sites by ATPase Prp28p

Yang, F., Wang, X. Y., Zhang, Z. M., Pu, J., Fan, Y. J., Zhou, J., Query, C. C. & Xu, Y. Z., Apr 1 2013, In : Nucleic acids research. 41, 8, p. 4660-4670 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Structural biology: Spliceosome's core exposed

Query, C. C. & Konarska, M. M., Jan 31 2013, In : Nature. 493, 7434, p. 615-616 2 p.

Research output: Contribution to journalComment/debate

7 Scopus citations
2012

A U1-U2 snRNP interaction network during intron definition

Shao, W., Kim, H. S., Cao, Y., Xu, Y. Z. & Query, C. C., Jan 2012, In : Molecular and cellular biology. 32, 2, p. 470-478 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome

Query, C. C. & Konarska, M. M., May 1 2012, In : RNA. 18, 5, p. 1001-1013 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
2011

Single-molecule mRNA decay measurements reveal promoter-regulated mRNA stability in yeast

Trcek, T., Larson, D. R., Moldón, A., Query, C. C. & Singer, R. H., Dec 23 2011, In : Cell. 147, 7, p. 1484-1497 14 p.

Research output: Contribution to journalArticle

162 Scopus citations
2010

Crossing the Exon

Moldón, A. & Query, C., Apr 23 2010, In : Molecular Cell. 38, 2, p. 159-161 3 p.

Research output: Contribution to journalShort survey

2 Scopus citations
2009

Insights into Branch Nucleophile Positioning and Activation from an Orthogonal Pre-mRNA Splicing System in Yeast

Smith, D. J., Konarska, M. M. & Query, C. C., May 15 2009, In : Molecular Cell. 34, 3, p. 333-343 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Structural biology: Spliceosome subunit revealed

Query, C. C., Mar 26 2009, In : Nature. 458, 7237, p. 418-419 2 p.

Research output: Contribution to journalShort survey

2 Scopus citations
2008

"Nought May Endure but Mutability": Spliceosome Dynamics and the Regulation of Splicing

Smith, D. J., Query, C. C. & Konarska, M. M., Jun 20 2008, In : Molecular Cell. 30, 6, p. 657-666 10 p.

Research output: Contribution to journalReview article

120 Scopus citations
2007

Competition between the ATPase Prp5 and Branch Region-U2 snRNA Pairing Modulates the Fidelity of Spliceosome Assembly

Xu, Y. Z. & Query, C. C., Dec 14 2007, In : Molecular Cell. 28, 5, p. 838-849 12 p.

Research output: Contribution to journalArticle

78 Scopus citations

Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing

Liu, L., Query, C. C. & Konarska, M. M., Jun 1 2007, In : Nature Structural and Molecular Biology. 14, 6, p. 519-526 8 p.

Research output: Contribution to journalArticle

70 Scopus citations

trans-Splicing to Spliceosomal U2 snRNA Suggests Disruption of Branch Site-U2 Pairing during Pre-mRNA Splicing

Smith, D. J., Query, C. C. & Konarska, M. M., Jun 22 2007, In : Molecular Cell. 26, 6, p. 883-890 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
2006

Repositioning of the reaction intermediate within the catalytic center of the spliceosome

Konarska, M. M., Vilardell, J. & Query, C. C., Feb 17 2006, In : Molecular Cell. 21, 4, p. 543-553 11 p.

Research output: Contribution to journalArticle

92 Scopus citations

Splicing fidelity revisited

Query, C. C. & Konarska, M. M., Jun 26 2006, In : Nature Structural and Molecular Biology. 13, 6, p. 472-474 3 p.

Research output: Contribution to journalShort survey

23 Scopus citations
2005

Insights into the mechanisms of splicing: More lessons from the ribosome

Konarska, M. M. & Query, C. C., Oct 1 2005, In : Genes and Development. 19, 19, p. 2255-2260 6 p.

Research output: Contribution to journalReview article

59 Scopus citations
2004

Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA

Xu, Y. Z., Newnham, C. M., Kameoka, S., Huang, T., Konarska, M. M. & Query, C. C., Jan 28 2004, In : EMBO Journal. 23, 2, p. 376-385 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants

Query, C. C. & Konarska, M. M., May 7 2004, In : Molecular Cell. 14, 3, p. 343-354 12 p.

Research output: Contribution to journalArticle

113 Scopus citations
2002

A glimpse of the catalytic core of a group II intron

Query, C. C., Jan 1 2002, In : Structure. 10, 4, p. 444-446 3 p.

Research output: Contribution to journalReview article

2 Scopus citations
55 Scopus citations

Pre-spliceosome formation in S.pombe requires a stable complex of SF1-U2AF59-U2AF23

Huang, T., Vilardell, J. & Query, C. C., Oct 15 2002, In : EMBO Journal. 21, 20, p. 5516-5526 11 p.

Research output: Contribution to journalArticle

40 Scopus citations
2001

A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site

Will, C. L., Schneider, C., Macmillan, A. M., Katopodis, N. F., Neubauer, G., Wilm, M., Lührmann, R. & Query, C. C., Aug 15 2001, In : EMBO Journal. 20, 16, p. 4536-4546 11 p.

Research output: Contribution to journalArticle

117 Scopus citations

The ATP requirement for U2 snRNP addition is linked to the pre-mRNA region 5′ to the branch site

Newnham, C. M. & Query, C. C., Sep 21 2001, In : RNA. 7, 9, p. 1298-1309 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2000

Joining of RNAs by splinted ligation

Moore, M. J. & Query, C. C., 2000, In : Methods in enzymology. 317, p. 109-123 15 p.

Research output: Contribution to journalArticle

112 Scopus citations
1997

A minimal spliceosomal complex A recognizes the branch site and polypyrimidine tract

Query, C. C., McCaw, P. S. & Sharp, P. A., May 1997, In : Molecular and cellular biology. 17, 5, p. 2944-2953 10 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations
1996

Three recognition events at the branch-site adenine

Query, C. C., Strobel, S. A. & Sharp, P. A., Mar 15 1996, In : EMBO Journal. 15, 6, p. 1392-1402 11 p.

Research output: Contribution to journalArticle

103 Scopus citations
1995

The branch site adenosine is recognized differently for the two steps of pre-mRNA splicing.

Query, C. C., Strobel, S. A. & Sharp, P. A., 1995, In : Nucleic acids symposium series. 33, p. 224-225 2 p.

Research output: Contribution to journalArticle

1 Scopus citations
1994

Branch nucleophile selection in pre-mRNA splicing: Evidence for the bulged duplex model

Query, C. C., Moore, M. J. & Sharp, P. A., Mar 1 1994, In : Genes and Development. 8, 5, p. 587-597 11 p.

Research output: Contribution to journalArticle

Open Access
161 Scopus citations

Dynamic association of proteins with the pre-mRNA branch region

MacMillan, A. M., Query, C. C., Allerson, C. R., Chen, S., Verdine, G. L. & Sharp, P. A., Dec 15 1994, In : Genes and Development. 8, 24, p. 3008-3020 13 p.

Research output: Contribution to journalArticle

Open Access
123 Scopus citations
1991

Nuclear RNA-binding Proteins

Keene, J. D. & Query, C. C., Jan 1 1991, In : Progress in Nucleic Acid Research and Molecular Biology. 41, C, p. 179-202 24 p.

Research output: Contribution to journalArticle

57 Scopus citations
Open Access
161 Scopus citations

RNA recognition: towards identifying determinants of specificity

Kenan, D. J., Query, C. C. & Keene, J. D., 1991, In : Trends in Biochemical Sciences. 16, C, p. 214-220 7 p.

Research output: Contribution to journalArticle

599 Scopus citations
1990

Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus

Clair, E. W. S., Query, C. C., Bentley, R., Keene, J. D., Polisson, R. P., Allen, N. B., Caldwell, D. S., Rice, J. R., Cox, C. & Pisetsky, D. S., Feb 1990, In : Clinical Immunology and Immunopathology. 54, 2, p. 266-280 15 p.

Research output: Contribution to journalArticle

18 Scopus citations
Open Access
134 Scopus citations
1989

A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein

Query, C. C., Bentley, R. C. & Keene, J. D., Apr 7 1989, In : Cell. 57, 1, p. 89-101 13 p.

Research output: Contribution to journalArticle

434 Scopus citations

A specific 31-nucleotide domain of U1 RNA directly interacts with the 70K small nuclear ribonucleoprotein component

Query, C. C., Bentley, R. C. & Keene, J. D., Jan 1 1989, In : Molecular and cellular biology. 9, 11, p. 4872-4881 10 p.

Research output: Contribution to journalArticle

Open Access
55 Scopus citations
1987

A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen

Query, C. C. & Keene, J. D., Oct 23 1987, In : Cell. 51, 2, p. 211-220 10 p.

Research output: Contribution to journalArticle

239 Scopus citations

The U1 RNA-specific 70K protein: RNA-binding studies and autoimmune cross-reactivity with type-C retroviruses

Query, C. C. & Keene, J. D., Sep 1 1987, In : Molecular Biology Reports. 12, 3, 1 p.

Research output: Contribution to journalArticle