• 3233 Citations
  • 30 h-Index
19972020

Research output per year

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Publications

  • 3233 Citations
  • 30 h-Index
  • 71 Article
  • 3 Chapter
  • 3 Review article
  • 1 Comment/debate
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Article
2020

FRS2α-dependent cell fate transition during endocardial cushion morphogenesis

Chen, D., Zhu, X., Kofler, N., Wang, Y., Zhou, B. & Simons, M., Feb 1 2020, In : Developmental Biology. 458, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

2019

Endocardially Derived Macrophages Are Essential for Valvular Remodeling

Shigeta, A., Huang, V., Zuo, J., Besada, R., Nakashima, Y., Lu, Y., Ding, Y., Pellegrini, M., Kulkarni, R. P., Hsiai, T., Deb, A., Zhou, B., Nakano, H. & Nakano, A., Mar 11 2019, In : Developmental cell. 48, 5, p. 617-630.e3

Research output: Contribution to journalArticle

5 Scopus citations

Inhibition of acetylation of histones 3 and 4 attenuates aortic valve calcification

Gu, J., Lu, Y., Deng, M., Qiu, M., Tian, Y., Ji, Y., Zong, P., Shao, Y., Zheng, R., Zhou, B., Sun, W. & Kong, X., Jul 1 2019, In : Experimental and Molecular Medicine. 51, 7, 79.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Spatiotemporal Gene Coexpression and Regulation in Mouse Cardiomyocytes of Early Cardiac Morphogenesis

Liu, Y., Lu, P., Wang, Y., Morrow, B. E., Zhou, B. & Zheng, D., Aug 6 2019, In : Journal of the American Heart Association. 8, 15, e012941.

Research output: Contribution to journalArticle

Open Access

Superoxide anions mediate the effects of angiotensin (1-7) analog, alamandine, on blood pressure and sympathetic activity in the paraventricular nucleus

Gong, J., Shen, Y., Li, P., Zhao, K., Chen, X., Li, Y., Sheng, Y., Zhou, B. & Kong, X., Aug 2019, In : Peptides. 118, 170101.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation

del Monte-Nieto, G., Ramialison, M., Adam, A. A. S., Wu, B., Aharonov, A., D’uva, G., Bourke, L. M., Pitulescu, M. E., Chen, H., de la Pompa, J. L., Shou, W., Adams, R. H., Harten, S. K., Tzahor, E., Zhou, B. & Harvey, R. P., Jan 1 2018, In : Nature. 557, 7705, p. 439-471 33 p.

Research output: Contribution to journalArticle

27 Scopus citations

Myocardial β-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation

Wang, Y., Lu, P., Wu, B., Riascos-Bernal, D. F., Sibinga, N. E. S., Valenta, T., Basler, K. & Zhou, B., Oct 2018, In : Journal of Molecular and Cellular Cardiology. 123, p. 150-158 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

NOTCH maintains developmental cardiac gene network through WNT5A

Wang, Y., Lu, P., Wu, B., Morrow, B. E. & Zhou, B., Dec 2018, In : Journal of Molecular and Cellular Cardiology. 125, p. 98-105 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Notch signaling regulates Hey2 expression in a spatiotemporal dependent manner during cardiac morphogenesis and trabecular specification

Miao, L., Li, J., Li, J., Tian, X., Lu, Y., Hu, S., Shieh, D., Kanai, R., Zhou, B. Y., Zhou, B., Liu, J., Firulli, A. B., Martin, J. F., Singer, H., Xin, H. & Wu, M., Dec 1 2018, In : Scientific reports. 8, 1, 2678.

Research output: Contribution to journalArticle

8 Scopus citations

Regulatory T Cells Promote Apelin-Mediated Sprouting Angiogenesis in Type 2 Diabetes

Leung, O. M., Li, J., Li, X., Chan, V. W., Yang, K. Y., Ku, M., Ji, L., Sun, H., Waldmann, H., Tian, X. Y., Huang, Y., Lau, J., Zhou, B. & Lui, K. O., Aug 7 2018, In : Cell Reports. 24, 6, p. 1610-1626 17 p.

Research output: Contribution to journalArticle

10 Scopus citations

Tbx20 is required in mid-gestation cardiomyocytes and plays a central role in atrial development

Boogerd, C. J., Zhu, X., Aneas, I., Sakabe, N., Zhang, L., Sobreira, D. R., Montefiori, L., Bogomolovas, J., Joslin, A. C., Zhou, B., Chen, J., Nobrega, M. A. & Evans, S. M., Jan 1 2018, In : Circulation research. 123, 4, p. 428-442 15 p.

Research output: Contribution to journalArticle

8 Scopus citations
2017

BMP2 expression in the endocardial lineage is required for AV endocardial cushion maturation and remodeling

Saxon, J. G., Baer, D. R., Barton, J. A., Hawkins, T., Wu, B., Trusk, T. C., Harris, S. E., Zhou, B., Mishina, Y. & Sugi, Y., Oct 1 2017, In : Developmental Biology. 430, 1, p. 113-128 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis

Goddard, L. M., Duchemin, A. L., Ramalingan, H., Wu, B., Chen, M., Bamezai, S., Yang, J., Li, L., Morley, M. P., Wang, T., Scherrer-Crosbie, M., Frank, D. B., Engleka, K. A., Jameson, S. C., Morrisey, E. E., Carroll, T. J., Zhou, B., Vermot, J. & Kahn, M. L., Nov 6 2017, In : Developmental cell. 43, 3, p. 274-289.e5

Research output: Contribution to journalArticle

29 Scopus citations

Notch-TNF signalling is required for development and homeostasis of arterial valves

Wang, Y., Wu, B., Farrar, E., Lui, W., Lu, P., Zhang, D., Alfieri, C. M., Mao, K., Chu, M., Yang, D., Xu, D., Rauchman, M., Taylor, V., Conway, S. J., Yutzey, K. E., Butcher, J. T. & Zhou, B., Mar 1 2017, In : European heart journal. 38, 9, p. 675-686 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling

Tai-Nagara, I., Yoshikawa, Y., Numata, N., Ando, T., Okabe, K., Sugiura, Y., Ieda, M., Takakura, N., Nakagawa, O., Zhou, B., Okabayashi, K., Suematsu, M., Kitagawa, Y., Bastmeyer, M., Sato, K., Klein, R., Navankasattusas, S., Li, D. Y., Yamagishi, S. & Kubota, Y., Jan 1 2017, In : Development (Cambridge). 144, 13, p. 2392-2401 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

REST regulates the cell cycle for cardiac development and regeneration

Zhang, D., Wang, Y., Lu, P., Wang, P., Yuan, X., Yan, J., Cai, C., Chang, C. P., Zheng, D., Wu, B. & Zhou, B., Dec 1 2017, In : Nature communications. 8, 1, 2210.

Research output: Contribution to journalArticle

12 Scopus citations

Sex-dependent aortic valve pathology in patients with rheumatic heart disease

Xiao, F., Zheng, R., Yang, D., Cao, K., Zhang, S., Wu, B., Shao, Y. & Zhou, B., Jun 1 2017, In : PLoS One. 12, 6, e0180230.

Research output: Contribution to journalArticle

1 Scopus citations

Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1

Wang, Y., Wu, B., Lu, P., Zhang, D., Wu, B., Varshney, S., Del Monte-Nieto, G., Zhuang, Z., Charafeddine, R., Kramer, A. H., Sibinga, N. E., Frangogiannis, N. G., Kitsis, R. N., Adams, R. H., Alitalo, K., Sharp, D. J., Harvey, R. P., Stanley, P. & Zhou, B., Dec 1 2017, In : Nature communications. 8, 1, 578.

Research output: Contribution to journalArticle

12 Scopus citations
2016

A series of robust genetic indicators for definitive identification of cardiomyocytes

Yan, J., Zhang, L., Sultana, N., Oh, J. G., Wu, B., Hajjar, R. J., Zhou, B. & Cai, C. L., Aug 1 2016, In : Journal of Molecular and Cellular Cardiology. 97, p. 278-285 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cadherin-11 Overexpression Induces Extracellular Matrix Remodeling and Calcification in Mature Aortic Valves

Sung, D. C., Bowen, C. J., Vaidya, K. A., Zhou, J., Chapurin, N., Recknagel, A., Zhou, B., Chen, J., Kotlikoff, M. & Butcher, J. T., Aug 1 2016, In : Arteriosclerosis, thrombosis, and vascular biology. 36, 8, p. 1627-1637 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Circumferential Strain Can Be Used to Detect Lipopolysaccharide-Induced Myocardial Dysfunction and Predict the Mortality of Severe Sepsis in Mice

Chu, M., Gao, Y., Zhou, B., Wu, B., Wang, J. & DiXu, May 1 2016, In : PLoS One. 11, 5, e0155346.

Research output: Contribution to journalArticle

5 Scopus citations

GATA4 regulates Fgf16 to promote heart repair after injury

Yu, W., Huang, X., Tian, X., Zhang, H., He, L., Wang, Y., Nie, Y., Hu, S., Lin, Z., Zhou, B., Pu, W., Lui, K. O. & Zhou, B., Mar 15 2016, In : Development (Cambridge). 143, 6, p. 936-949 14 p.

Research output: Contribution to journalArticle

38 Scopus citations

Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts

Zhang, D., Wu, B., Wang, P., Wang, Y., Lu, P., Nechiporuk, T., Floss, T., Greally, J. M., Zheng, D. & Zhou, B., 2016, In : Nucleic Acids Research. 45, 6, p. 3102-3115 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Probing chromatin landscape reveals roles of endocardial TBX20 in septation

Boogerd, C. J., Aneas, I., Sakabe, N., Dirschinger, R. J., Cheng, Q. J., Zhou, B., Chen, J., Nobrega, M. A. & Evans, S. M., Aug 1 2016, In : Journal of Clinical Investigation. 126, 8, p. 3023-3035 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis

MacGrogan, D., D'Amato, G., Travisano, S., Martinez-Poveda, B., Luxán, G., Del Monte-Nieto, G., Papoutsi, T., Sbroggio, M., Bou, V., Gomez-Del Arco, P., Gómez, M. J., Zhou, B., Redondo, J. M., Jiménez-Borreguero, L. J. & De La Pompa, J. L., May 13 2016, In : Circulation Research. 118, 10, p. 1480-1497 18 p.

Research output: Contribution to journalArticle

40 Scopus citations

Single-Cell Lineage Tracing Reveals that Oriented Cell Division Contributes to Trabecular Morphogenesis and Regional Specification

Li, J., Miao, L., Shieh, D., Spiotto, E., Li, J., Zhou, B., Paul, A., Schwartz, R. J., Firulli, A. B., Singer, H. A., Huang, G. & Wu, M., Apr 5 2016, In : Cell Reports. 15, 1, p. 158-170 13 p.

Research output: Contribution to journalArticle

24 Scopus citations
2015

Characterization of heterotopic ossification using radiographic imaging: Evidence for a paradigm shift

Brownley, R. C., Agarwal, S., Loder, S., Eboda, O., Li, J., Peterson, J., Hwang, C., Breuler, C., Kaartinen, V., Zhou, B., Mishina, Y. & Levi, B., Nov 6 2015, In : PloS one. 10, 11, e0141432.

Research output: Contribution to journalArticle

8 Scopus citations

Cranial neural crest deletion of VEGFa causes cleft palate with aberrant vascular and bone development

Hill, C., Jacobs, B., Kennedy, L., Rohde, S., Zhou, B., Baldwin, S. & Goudy, S., Sep 28 2015, In : Cell and Tissue Research. 361, 3, p. 711-722 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade

Hathaway, C. K., Grant, R., Hagaman, J. R., Hiller, S., Li, F., Xu, L., Chang, A. S., Madden, V. J., Bagnell, C. R., Rojas, M., Kim, H. S., Wu, B., Zhou, B., Smithies, O. & Kakoki, M., Apr 21 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 16, p. 5141-5146 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation

Racedo, S. E., McDonald-Mcginn, D. M., Chung, J. H., Goldmuntz, E., Zackai, E., Emanuel, B. S., Zhou, B., Funke, B. & Morrow, B. E., Feb 5 2015, In : American Journal of Human Genetics. 96, 2, p. 235-244 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Resident c-kit + cells in the heart are not cardiac stem cells

Sultana, N., Zhang, L., Yan, J., Chen, J., Cai, W., Razzaque, S., Jeong, D., Sheng, W., Bu, L., Xu, M., Huang, G. Y., Hajjar, R. J., Zhou, B., Moon, A. & Cai, C. L., Oct 30 2015, In : Nature communications. 6, 8701.

Research output: Contribution to journalArticle

157 Scopus citations

The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK3 Signaling and KLF Expression

Zhou, Z., Rawnsley, D. R., Goddard, L. M., Pan, W., Cao, X. J., Jakus, Z., Zheng, H., Yang, J., Arthur, J. S. C., Whitehead, K. J., Li, D., Zhou, B., Garcia, B. A., Zheng, X. & Kahn, M. L., Jan 26 2015, In : Developmental cell. 32, 2, p. 168-180 13 p.

Research output: Contribution to journalArticle

61 Scopus citations

The role of speckle tracking echocardiography in assessment of lipopolysaccharide-induced myocardial dysfunction in mice

Chu, M., Gao, Y., Zhang, Y., Zhou, B., Wu, B., Yao, J. & Xu, D., Jan 1 2015, In : Journal of Thoracic Disease. 7, 12, p. 2253-2261 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Tie1 is required for lymphatic valve and collecting vessel development

Qu, X., Zhou, B. & Scott Baldwin, H., Mar 1 2015, In : Developmental Biology. 399, 1, p. 117-128 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Vertebrate Fidgetin Restrains Axonal Growth by Severing Labile Domains of Microtubules

Leo, L., Yu, W., D'Rozario, M., Waddell, E. A., Marenda, D. R., Baird, M. A., Davidson, M. W., Zhou, B., Wu, B., Baker, L., Sharp, D. J. & Baas, P. W., Sep 22 2015, In : Cell Reports. 12, 11, p. 1723-1730 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
2014

A long noncoding RNA protects the heart from pathological hypertrophy

Han, P., Li, W., Lin, C. H., Yang, J., Shang, C., Nurnberg, S. T., Jin, K. K., Xu, W., Lin, C. Y., Lin, C. J., Xiong, Y., Chien, H. C., Zhou, B., Ashley, E., Bernstein, D., Chen, P. S., Chen, H. S. V., Quertermous, T. & Chang, C. P., Oct 2 2014, In : Nature. 514, 7520, p. 102-106 5 p.

Research output: Contribution to journalArticle

368 Scopus citations

DNA methylation is developmentally regulated for genes essential for cardiogenesis

Chamberlain, A. A., Lin, M., Lister, R. L., Maslov, A. A., Wang, Y., Suzuki, M., Wu, B., Greally, J. M., Zheng, D. & Zhou, B., Jan 1 2014, In : Journal of the American Heart Association. 3, 3, 000976.

Research output: Contribution to journalArticle

29 Scopus citations

Epicardial calcineurin-NFAT signals through Smad2 to direct coronary smooth muscle cell and arterial wall development

Yang, J., Zeini, M., Lin, C. Y., Lin, C. J., Xiong, Y., Shang, C., Han, P., Li, W., Quertermous, T., Zhou, B. & Chang, C. P., Jan 1 2014, In : Cardiovascular research. 101, 1, p. 120-129 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Hand2 Is an Essential Regulator for Two Notch-Dependent Functions within the Embryonic Endocardium

VanDusen, N. J., Casanovas, J., Vincentz, J. W., Firulli, B. A., Osterwalder, M., Lopez-Rios, J., Zeller, R., Zhou, B., Grego-Bessa, J., DeLaPompa, J., Shou, W. & Firulli, A. B., Dec 24 2014, In : Cell Reports. 9, 6, p. 2071-2083 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis

Moore-Morris, T., Guimarães-Camboa, N., Banerjee, I., Zambon, A. C., Kisseleva, T., Velayoudon, A., Stallcup, W. B., Gu, Y., Dalton, N. D., Cedenilla, M., Gomez-Amaro, R., Zhou, B., Brenner, D. A., Peterson, K. L., Chen, J. & Evans, S. M., Jul 1 2014, In : Journal of Clinical Investigation. 124, 7, p. 2921-2934 14 p.

Research output: Contribution to journalArticle

251 Scopus citations
2013

Accelerated Coronary Angiogenesis by Vegfr1-Knockout Endocardial Cells

Zhang, Z. & Zhou, B., Jul 24 2013, In : PloS one. 8, 7, e70570.

Research output: Contribution to journalArticle

15 Scopus citations

Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair

Xiong, Y., Li, W., Shang, C., Chen, R. M., Han, P., Yang, J., Stankunas, K., Wu, B., Pan, M., Zhou, B., Longaker, M. T. & Chang, C. P., Apr 29 2013, In : Developmental cell. 25, 2, p. 169-181 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Endocardial to Myocardial Notch-Wnt-Bmp Axis Regulates Early Heart Valve Development

Wang, Y., Wu, B., Chamberlain, A. A., Lui, W., Koirala, P., Susztak, K., Klein, D., Taylor, V. & Zhou, B., Apr 1 2013, In : PloS one. 8, 4, e60244.

Research output: Contribution to journalArticle

43 Scopus citations

Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis

Cai, X., Zhang, W., Hu, J., Zhang, L., Sultana, N., Wu, B., Cai, W., Zhou, B. & Cai, C. L., Aug 1 2013, In : Development (Cambridge). 140, 15, p. 3176-3187 12 p.

Research output: Contribution to journalArticle

47 Scopus citations
2012

Astragaloside IV alleviates hypoxia/reoxygenation-induced neonatal rat cardiomyocyte injury via the protein kinase a pathway

Zhang, D. W., Bian, Z. P., Xu, J. D., Wu, H. F., Gu, C. R., Zhou, B., Chen, X. J. & Yang, D., Aug 1 2012, In : Pharmacology. 90, 1-2, p. 95-101 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Developmental basis for filamin-A-associated myxomatous mitral valve disease

Sauls, K., De Vlaming, A., Harris, B. S., Williams, K., Wessels, A., Levine, R. A., Slaugenhaupt, S. A., Goodwin, R. L., Pavone, L. M., Merot, J., Schott, J. J., Le Tourneau, T., Dix, T., Jesinkey, S., Feng, Y., Walsh, C., Zhou, B., Baldwin, S., Markwald, R. R. & Norris, R. A., Oct 1 2012, In : Cardiovascular research. 96, 1, p. 109-119 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling

Wu, B., Zhang, Z., Lui, W., Chen, X., Wang, Y., Chamberlain, A. A., Moreno-Rodriguez, R. A., Markwald, R. R., O'Rourke, B. P., Sharp, D. J., Zheng, D., Lenz, J., Baldwin, H. S., Chang, C. P. & Zhou, B., Nov 21 2012, In : Cell. 151, 5, p. 1083-1096 14 p.

Research output: Contribution to journalArticle

191 Scopus citations

The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve development

Lin, C. Y., Lin, C. J., Chen, C. H., Chen, R. M., Zhou, B. & Chang, C. P., May 1 2012, In : Journal of Molecular and Cellular Cardiology. 52, 5, p. 1096-1102 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
2011

Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryos

Song, L., Zhao, M., Wu, B., Zhou, B., Wang, Q. & Jiao, K., Jan 1 2011, In : Developmental Dynamics. 240, 1, p. 211-220 10 p.

Research output: Contribution to journalArticle

15 Scopus citations