• 10405 Citations
  • 38 h-Index
19972020

Research output per year

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Publications

2016

Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression

Yong, K. J., Basseres, D. S., Welner, R. S., Zhang, W. C., Yang, H., Yan, B., Alberich-Jorda, M., Zhang, J., De Figueiredo-Pontes, L. L., Battelli, C., Hetherington, C. J., Ye, M., Zhang, H., Maroni, G., O'Brien, K., Magli, M. C., Borczuk, A. C., Varticovski, L., Kocher, O., Zhang, P. & 12 others, Moon, Y. C., Sydorenko, N., Cao, L., Davis, T. W., Thakkar, B. M., Soo, R. A., Iwama, A., Lim, B., Halmos, B., Neuberg, D., Tenen, D. G. & Levantini, E., Aug 3 2016, In : Science Translational Medicine. 8, 350, p. 350ra104

Research output: Contribution to journalArticle

26 Scopus citations

The Evolving Role of Biomarkers in Personalized Lung Cancer Therapy

Sharma, J. N., Shum, E., Chau, V., Paucar, D., Cheng, H. & Halmos, B., Dec 1 2016, In : Respiration. 93, 1, p. 1-14 14 p.

Research output: Contribution to journalReview article

4 Scopus citations

Update in lung cancer 2015

Spira, A., Halmos, B. & Powell, C. A., Sep 15 2016, In : American Journal of Respiratory and Critical Care Medicine. 194, 6, p. 661-671 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Does lung cancer mutation status and targeted therapy predict for outcomes and local control in the setting of brain metastases treated with radiation?

Wang, T. J. C., Saad, S., Qureshi, Y. H., Jani, A., Nanda, T., Yaeh, A. M., Rozenblat, T., Sisti, M. B., Bruce, J. N., McKhann, G. M., Lesser, J., Halmos, B., Stoopler, M. B., Lassman, A. B., Cheng, S. K. & Isaacson, S. R., Jul 1 2015, In : Neuro-Oncology. 17, 7, p. 1022-1028 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Randomized phase II trial of erlotinib beyond progression in advanced erlotinib-responsive non-small cell lung cancer

Halmos, B., Pennell, N. A., Fu, P., Saad, S., Gadgeel, S., Otterson, G. A., Mekhail, T., Snell, M., Kuebler, J. P., Sharma, N. & Dowlati, A., Aug 25 2015, In : Oncologist. 20, 11, p. 1298-1303 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

RICTOR amplification defines a novel subset of patients with lung cancer who may benefit from treatment with mTORC1/2 inhibitors

Cheng, H., Zou, Y., Ross, J. S., Wang, K., Liu, X., Halmos, B., Ali, S. M., Liu, H., Verma, A., Montagna, C., Chachoua, A., Goel, S., Schwartz, E. L., Zhu, C., Shan, J., Yu, Y., Gritsman, K., Yelensky, R., Lipson, D., Otto, G. & 5 others, Hawryluk, M., Stephens, P. J., Miller, V. A., Piperdi, B. & Perez-Soler, R., Dec 2015, In : Cancer discovery. 5, 12, p. 1262-1270 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Simpson's paradox - Aggregating and partitioning populations in health disparities of lung cancer patients

Fu, P., Panneerselvam, A., Clifford, B., Dowlati, A., Ma, P. C., Zeng, G., Halmos, B. & Leidner, R. S., Dec 1 2015, In : Statistical Methods in Medical Research. 24, 6, p. 937-948 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Update in lung cancer 2014

Spira, A., Halmos, B. & Powell, C. A., Aug 1 2015, In : American journal of respiratory and critical care medicine. 192, 3, p. 283-294 12 p.

Research output: Contribution to journalArticle

26 Scopus citations
2014

A randomized, phase 2 trial of docetaxel with or without PX-866, an irreversible oral phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or metastatic non-small-cell lung cancer

Levy, B., Spira, A., Becker, D., Evans, T., Schnadig, I., Camidge, D. R., Bauman, J. E., Hausman, D., Walker, L., Nemunaitis, J., Rudin, C. M., Halmos, B. & Bowles, D. W., Jul 2014, In : Journal of Thoracic Oncology. 9, 7, p. 1031-1035 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

AXL kinase as a novel target for cancer therapy

Wu, X., Liu, X., Koul, S., Lee, C. Y., Zhang, Z. & Halmos, B., Jan 1 2014, In : Oncotarget. 5, 20, p. 9546-9563 18 p.

Research output: Contribution to journalArticle

Open Access
103 Scopus citations

Complete pathological response in a patient with metastatic esophageal cancer treated with a regimen of capecitabine, oxaliplatin and docetaxel: a case report

Seetharamu, N., Melamed, J., Miller, G., Rotterdam, H., Gonda, T., Villanueva, G. & Halmos, B., Dec 1 2014, In : Journal of Gastrointestinal Cancer. 45, p. 108-111 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Modulation of ErbB2 blockade in ErbB2-positive cancers: The role of ErbB2 mutations and PHLDA1

Li, G., Wang, X., Hibshoosh, H., Jin, C. & Halmos, B., Sep 19 2014, In : PloS one. 9, 9, e106349.

Research output: Contribution to journalArticle

16 Scopus citations

Molecular testing guidelines for lung adenocarcinoma: Utility of cell blocks and concordance between fine-needle aspiration cytology and histology samples

Heymann, J., Bulman, W., Maxfield, R., Powell, C., Halmos, B., Sonett, J., Beaubier, N., Crapanzano, J., Mansukhani, M. & Saqi, A., Jan 1 2014, In : CytoJournal. 11, 1, 12.

Research output: Contribution to journalArticle

21 Scopus citations

Phase II trial of Sorafenib in conjunction with chemotherapy and as maintenance therapy in extensive-stage small cell lung cancer

Sharma, N., Pennell, N., Nickolich, M., Halmos, B., Ma, P., Mekhail, T., Fu, P. & Dowlati, A., Apr 2014, In : Investigational New Drugs. 32, 2, p. 362-368 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

PIAS3 activates the intrinsic apoptotic pathway in non-small cell lung cancer cells independent of p53 status

Dabir, S., Kluge, A., McColl, K., Liu, Y., Lam, M., Halmos, B., Wildey, G. & Dowlati, A., Mar 1 2014, In : International Journal of Cancer. 134, 5, p. 1045-1054 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
6 Scopus citations

The seventh door

Halmos, B., Jan 1 2014, In : Oncologist. 19, 5, p. 574-575 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
2013

A Phase i Study of the combination of oxaliplatin/docetaxel and vandetanib for the treatment of advanced gastroesophageal cancer

Halmos, B., Jia, Y., Bokar, J. A., Fu, P., Adelstein, D. J., Juergens, R., Rodal, M. B. & Dowlati, A., Oct 1 2013, In : Investigational New Drugs. 31, 5, p. 1244-1250 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Combined histone deacetylase and cyclooxygenase inhibition achieves enhanced antiangiogenic effects in lung cancer cells

Wang, X., Li, G., Wang, A., Zhang, Z., Merchan, J. R. & Halmos, B., Mar 1 2013, In : Molecular Carcinogenesis. 52, 3, p. 218-228 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

EGFR molecular testing in African-American non-small cell lung cancer patients - A review of discrepant data

Clifford, B. T., Fu, P., Pennell, N. A., Halmos, B. & Leidner, R. S., 2013, In : Translational Lung Cancer Research. 2, 3, p. 251-255 5 p.

Research output: Contribution to journalReview article

8 Scopus citations

PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells

Cheng, H., Zhang, Z., Borczuk, A., Powell, C. A., Balajee, A. S., Lieberman, H. B. & Halmos, B., Apr 1 2013, In : Carcinogenesis. 34, 4, p. 739-749 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

Thymidylate synthase expression and molecular alterations in adenosquamous carcinoma of the lung

Shu, C., Cheng, H., Wang, A., Mansukhani, M. M., Powell, C. A., Halmos, B. & Borczuk, A. C., Feb 1 2013, In : Modern Pathology. 26, 2, p. 239-246 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Update in lung cancer and mesothelioma 2012

Powell, C. A., Halmos, B. & Nana-Sinkam, S. P., Jul 15 2013, In : American journal of respiratory and critical care medicine. 188, 2, p. 157-166 10 p.

Research output: Contribution to journalArticle

22 Scopus citations
2012

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

Zhang, Z., Lee, J. C., Lin, L., Olivas, V., Au, V., Laframboise, T., Abdel-Rahman, M., Wang, X., Levine, A. D., Rho, J. K., Choi, Y. J., Choi, C. M., Kim, S. W., Jang, S. J., Park, Y. S., Kim, W. S., Lee, D. H., Lee, J. S., Miller, V. A., Arcila, M. & 10 others, Ladanyi, M., Moonsamy, P., Sawyers, C., Boggon, T. J., Ma, P. C., Costa, C., Taron, M., Rosell, R., Halmos, B. & Bivona, T. G., Aug 1 2012, In : Nature Genetics. 44, 8, p. 852-860 9 p.

Research output: Contribution to journalArticle

685 Scopus citations

Cancer: Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers

Katayama, R., Shaw, A. T., Khan, T. M., Mino-Kenudson, M., Solomon, B. J., Halmos, B., Jessop, N. A., Wain, J. C., Yeo, A. T., Benes, C., Drew, L., Saeh, J. C., Crosby, K., Sequist, L. V., Iafrate, A. J. & Engelman, J. A., Feb 8 2012, In : Science translational medicine. 4, 120

Research output: Contribution to journalArticle

840 Scopus citations

Frequent downregulation of the transcription factor Foxa2 in lung cancer through epigenetic silencing

Basseres, D. S., D'Alò, F., Yeap, B. Y., Löwenberg, E. C., Gonzalez, D. A., Yasuda, H., Dayaram, T., Kocher, O. N., Godleski, J. J., Richards, W. G., Meyerson, M., Kobayashi, S., Tenen, D. G., Halmos, B. & Costa, D. B., Jul 1 2012, In : Lung Cancer. 77, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Management of esophageal squamous cell carcinoma with definitive chemoradiotherapy in a patient with scleroderma: Case report and review of the literature

Horowitz, D. P., Halmos, B., Poneros, J., Sonett, J., Remotti, H. & Burri, R. J., Sep 1 2012, In : Journal of Gastrointestinal Cancer. 43, SUPPL. 1, p. S156-S160

Research output: Contribution to journalReview article

Phase-II trial of rebeccamycin analog, a dual topoisomerase-I and -II inhibitor, in relapsed "sensitive" small cell lung cancer

Schwandt, A., Mekhail, T., Halmos, B., O'Brien, T., Ma, P. C., Fu, P., Ivy, P. & Dowlati, A., Apr 1 2012, In : Journal of Thoracic Oncology. 7, 4, p. 751-754 4 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

MET-independent lung cancer cells evading EGFR kinase inhibitors are therapeutically susceptible to BH3 mimetic agents

Fan, W., Tang, Z., Yin, L., Morrison, B., Hafez-Khayyata, S., Fu, P., Huang, H., Bagai, R., Jiang, S., Kresak, A., Howell, S., Vasanji, A., Flask, C. A., Halmos, B., Koon, H. & Ma, P. C., Jul 1 2011, In : Cancer Research. 71, 13, p. 4494-4505 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Update in lung cancer and oncological disorders 2010

Halmos, B. & Powell, C. A., Aug 1 2011, In : American Journal of Respiratory and Critical Care Medicine. 184, 3, p. 297-302 6 p.

Research output: Contribution to journalReview article

6 Scopus citations
2010

CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells

O'Brien, K. B., Alberich-Jordà, M., Yadav, N., Kocher, O., DiRuscio, A., Ebralidze, A., Levantini, E., Sng, N. J. L., Bhasin, M., Caron, T., Kim, D., Steidl, U., Huang, G., Halmos, B., Rodig, S. J., Bedford, M. T., Tenen, D. G. & Kobayashi, S., Jul 1 2010, In : Development. 137, 13, p. 2147-2156 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells

Zhang, Z., Kobayashi, S., Borczuk, A. C., Leidner, R. S., LaFramboise, T., Levine, A. D. & Halmos, B., Jan 22 2010, In : Carcinogenesis. 31, 4, p. 577-586 10 p.

Research output: Contribution to journalArticle

111 Scopus citations

EGFR-mutated lung cancer: a paradigm of molecular oncology.

Zhang, Z., Stiegler, A. L., Boggon, T. J., Kobayashi, S. & Halmos, B., Nov 2010, In : Oncotarget. 1, 7, p. 497-514 18 p.

Research output: Contribution to journalReview article

Open Access
140 Scopus citations

Molecular testing in lung cancer: The time is now

Cheng, H., Xu, X., Costa, D. B., Powell, C. A. & Halmos, B., Sep 1 2010, In : Current oncology reports. 12, 5, p. 335-348 14 p.

Research output: Contribution to journalReview article

17 Scopus citations
2009

A randomized phase 2 study of erlotinib alone and in combination with bortezomib in previously treated advanced non-small cell lung cancer

Lynch, T. J., Fenton, D., Hirsh, V., Bodkin, D., Middleman, E. L., Chiappori, A., Halmos, B., Favis, R., Liu, H., Trepicchio, W. L., Eton, O. & Shepherd, F. A., Aug 2009, In : Journal of Thoracic Oncology. 4, 8, p. 1002-1009 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Combined vascular endothelial growth factor receptor and Epidermal Growth Factor Receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance

Naumov, G. N., Nilsson, M. B., Cascone, T., Briggs, A., Straume, O., Akslen, L. A., Lifshits, E., Byers, L. A., Xu, L., Wu, H. K., Jänne, P., Kobayashi, S., Halmos, B., Tenen, D., Tang, X. M., Engelman, J., Yeap, B., Folkman, J., Johnson, B. E. & Heymach, J. V., May 15 2009, In : Clinical Cancer Research. 15, 10, p. 3484-3494 11 p.

Research output: Contribution to journalArticle

203 Scopus citations

Cooperative interaction between protein inhibitor of activated signal transducer and activator of transcription-3 with epidermal growth factor receptor blockade in lung cancer

Kluge, A., Dabir, S., Kern, J., Nethery, D., Halmos, B., Ma, P. & Dowlati, A., Oct 1 2009, In : International Journal of Cancer. 125, 7, p. 1728-1734 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

CTCs - Ready to take center stage?

Halmos, B., Jul 1 2009, In : American Journal of Hematology/ Oncology. 8, 7

Research output: Contribution to journalComment/debate

Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity

Tang, Z., Jiang, S., Du, R., Petri, E. T., El-Telbany, A., Chan, P. S. O., Kijima, T., Dietrich, S., Matsui, K., Kobayashi, M., Sasada, S., Okamoto, N., Suzuki, H., Kawahara, K., Iwasaki, T., Nakagawa, K., Kawase, I., Christensen, J. G., Hirashima, T., Halmos, B. & 4 others, Salgia, R., Boggon, T. J., Kern, J. A. & Ma, P. C., Jan 29 2009, In : Oncogene. 28, 4, p. 518-533 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Dysregulation of the C/EBPα differentiation pathway in human cancer

Koschmieder, S., Halmos, B., Levantini, E. & Tenen, D. G., Feb 1 2009, In : Journal of Clinical Oncology. 27, 4, p. 619-628 10 p.

Research output: Contribution to journalReview article

140 Scopus citations

Genetic abnormalities of the EGFR pathway in African American patients with non-small-cell lung cancer

Leidner, R. S., Fu, P., Clifford, B., Hamdan, A., Jin, C., Eisenberg, R., Boggon, T. J., SkokanM., M., Franklin, W. A., Cappuzzo, F., Hirsch, F. R., Varella-Garcia, M. & Halmos, B., Nov 20 2009, In : Journal of Clinical Oncology. 27, 33, p. 5620-5626 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Predictive markers of esophageal cancer-in search of the main charAKTers

Leidner, R. S., LaFramboise, T. & Halmos, B., Sep 1 2009, In : American Journal of Hematology/ Oncology. 8, 9

Research output: Contribution to journalComment/debate

2008

15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3β and a tumor suppressor in lung cancer

Huang, G., Eisenberg, R., Yan, M., Monti, S., Lawrence, E., Fu, P., Walbroehl, J., Löwenberg, E., Golub, T., Merchan, J., Tenen, D. G., Markowitz, S. D. & Halmos, B., Jul 1 2008, In : Cancer Research. 68, 13, p. 5040-5048 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer

Tang, Z., Du, R., Jiang, S., Wu, C., Barkauskas, D. S., Richey, J., Molter, J., Lam, M., Flask, C., Gerson, S., Dowlati, A., Liu, L., Lee, Z., Halmos, B., Wang, Y., Kern, J. A. & Ma, P. C., Sep 16 2008, In : British Journal of Cancer. 99, 6, p. 911-922 12 p.

Research output: Contribution to journalArticle

140 Scopus citations

Effects of erlotinib in EGFR mutated non-small cell lung cancers with resistance to gefitinib

Costa, D. B., Nguyen, K. S. H., Cho, B. C., Sequist, L. V., Jackman, D. M., Riely, G. J., Yeap, B. Y., Halmos, B., Kim, J. H., Jänne, P. A., Huberman, M. S., Pao, W., Tenen, D. G. & Kobayashi, S., Nov 1 2008, In : Clinical Cancer Research. 14, 21, p. 7060-7067 8 p.

Research output: Contribution to journalArticle

146 Scopus citations
14 Scopus citations

Structure and clinical relevance of the epidermal growth factor receptor in human cancer

Kumar, A., Petri, E. T., Halmos, B. & Boggon, T. J., Sep 15 2008, In : Journal of Clinical Oncology. 26, 10, p. 1742-1751 10 p.

Research output: Contribution to journalReview article

192 Scopus citations
2007

BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations

Costa, D. B., Halmos, B., Kumar, A., Schumer, S. T., Huberman, M. S., Boggon, T. J., Tenen, D. G. & Kobayashi, S., Oct 1 2007, In : PLoS Medicine. 4, 10, p. 1669-1680 12 p.

Research output: Contribution to journalArticle

373 Scopus citations

Immunohistochemical analysis of C/EBPα in non-small cell lung cancer reveals frequent down-regulation in stage II and IIIA tumors: A correlative study of E3590

Costa, D. B., Li, S., Kocher, O., Feins, R. H., Keller, S. M., Schiller, J. H., Johnson, D. H., Tenen, D. G. & Halmos, B., Apr 1 2007, In : Lung Cancer. 56, 1, p. 97-103 7 p.

Research output: Contribution to journalArticle

17 Scopus citations