• 10405 Citations
  • 38 h-Index
19972020

Research output per year

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Publications

1997

Interpopulation effect of ACE I/D polymorphism on serum concentration of ACE in diagnosis of sarcoidosis [10]

Csaszar, A., Halmos, B., Palicz, T., Szalai, C. & Romics, L., Jan 1 1997, In : Lancet. 350, 9076, 1 p.

Research output: Contribution to journalLetter

18 Scopus citations
1999

Genetic investigation of patients with hypercholesterolemia type IIa [4]

Szalai, C., Csaszar, A., Czinner, A., Palicz, T., Halmos, B. & Romics, L., Feb 13 1999, In : Clinical Genetics. 55, 1, p. 67-68 2 p.

Research output: Contribution to journalLetter

1 Scopus citations

Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells

Agarwal, B., Bhendwal, S., Halmos, B., Moss, S. F., Ramey, W. G. & Holt, P. R., Aug 1 1999, In : Clinical Cancer Research. 5, 8, p. 2223-2229 7 p.

Research output: Contribution to journalArticle

220 Scopus citations
2000

Association of primary biliary cirrhosis with vitamin D receptor BsmI genotype polymorphism in a Hungarian population

Halmos, B., Szalay, F., Cserniczky, T., Nemesanszky, E., Lakatos, P., Barlage, S., Schmitz, G., Romics, L. & Csaszar, A., Jul 6 2000, In : Digestive Diseases and Sciences. 45, 6, p. 1091-1095 5 p.

Research output: Contribution to journalArticle

47 Scopus citations
2002

Colonic epithelial cell proliferation decreases with increasing levels of serum 25-hydroxy vitamin D

Holt, P. R., Arber, N., Halmos, B., Kissileff, H., Moss, S. F., Holt, P. R., Arber, N., Halmos, B., Kissileff, H., Moss, S. F., Forde, K., McGlynn, K. A., Fan, K., Yang, K. & Lipkin, M., Jan 1 2002, In : Cancer Epidemiology Biomarkers and Prevention. 11, 1, p. 113-119 7 p.

Research output: Contribution to journalArticle

132 Scopus citations

Down-regulation and antiproliferative role of C/EBPα in lung cancer

Halmos, B., Karp, D. D., Kocher, O., Huettner, C. S., Tenen, D. G. & Ferenczi, K., Jan 15 2002, In : Cancer Research. 62, 2, p. 528-534 7 p.

Research output: Contribution to journalArticle

108 Scopus citations

Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells

Agarwal, B., Halmos, B., Feoktistov, A. S., Protiva, P., Ramey, W. G., Chen, M., Pothoulakis, C., Lamont, J. T. & Holt, P. R., Jan 1 2002, In : Carcinogenesis. 23, 3, p. 521-528 8 p.

Research output: Contribution to journalArticle

Open Access
74 Scopus citations
2003

Lung cancer

Halmos, B., Boiselle, P. M. & Karp, D. D., Jan 1 2003, In : Primary Care Update for Ob/Gyns. 10, 3, p. 87-94 8 p.

Research output: Contribution to journalReview article

5 Scopus citations
2004

Activating mutations of the Noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

Bentires-Alj, M., Paez, J. G., David, F. S., Keilhack, H., Halmos, B., Naoki, K., Maris, J. M., Richardson, A., Bardelli, A., Sagarbaker, D. J., Richards, W. G., Du, J., Girard, L., Minna, J. D., Loh, M. L., Fisher, D. E., Velculescu, V. E., Vogelstein, B., Meyerson, M., Sellers, W. R. & 1 others, Neel, B. G., Dec 15 2004, In : Cancer Research. 64, 24, p. 8816-8820 5 p.

Research output: Contribution to journalArticle

344 Scopus citations

A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3β as a novel tumor suppressor in lung cancer

Halmos, B., Bassères, D. S., Monti, S., D'Aló, F., Dayaram, T., Ferenczi, K., Wouters, B. J., Huettner, C. S., Golub, T. R. & Tenen, D. G., Jun 15 2004, In : Cancer Research. 64, 12, p. 4137-4147 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Extreme lymphoplasmacytosis and hepatic failure associated with sulfasalazine hypersensitivity reaction and a concurrent EBV infection - Case report and review of the literature

Halmos, B., Anastopoulos, H. T., Schnipper, L. E. & Ballesteros, E., Apr 1 2004, In : Annals of Hematology. 83, 4, p. 242-246 5 p.

Research output: Contribution to journalArticle

10 Scopus citations
2005

An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor

Kobayashi, S., Ji, H., Yuza, Y., Meyerson, M., Wong, K. K., Tenen, D. G. & Halmos, B., Aug 15 2005, In : Cancer Research. 65, 16, p. 7096-7101 6 p.

Research output: Contribution to journalArticle

218 Scopus citations

Case 4. Mutation of the epidermal growth factor receptor in an elderly man with advanced, gefitinib-responsive, non-small-cell lung cancer

Cho, D., Kocher, O., Tenen, D. G., Halmos, B., Lee, J. C., Meyerson, M. L. & Janne, P. A., Jan 1 2005, In : Journal of Clinical Oncology. 23, 1, p. 235-237 3 p.

Research output: Contribution to journalArticle

9 Scopus citations

Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations

Mukohara, T., Engelman, J. A., Hanna, N. H., Yeap, B. Y., Kobayashi, S., Lindeman, N., Halmos, B., Pearlberg, J., Tsuchihashi, Z., Cantley, L. C., Tenen, D. G., Johnson, B. E. & Jänne, P. A., Aug 1 2005, In : Journal of the National Cancer Institute. 97, 16, p. 1185-1194 10 p.

Research output: Contribution to journalArticle

271 Scopus citations

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

Kobayashi, S., Boggon, T. J., Dayaram, T., Jänne, P. A., Kocher, O., Meyerson, M., Johnson, B. E., Eck, M. J., Tenen, D. G. & Halmos, B., Feb 24 2005, In : New England Journal of Medicine. 352, 8, p. 786-792 7 p.

Research output: Contribution to journalArticle

2978 Scopus citations

EGFR mutation and response of lung cancer to gefitinib [3] (multiple letters)

Toyooka, S., Kiura, K., Mitsudomi, T., Kobayashi, S., Tenen, D. G. & Halmos, B., May 19 2005, In : New England Journal of Medicine. 352, 20, 1 p.

Research output: Contribution to journalLetter

101 Scopus citations

Uncommon presentations of some common malignancies: Case 1. Sequential paraneoplastic endocrine syndromes in small-cell lung cancer

Mayer, S., Cypess, A. M., Kocher, O. N., Herman, S. M., Huberman, M. S., Hartzband, P. I. & Halmos, B., Feb 20 2005, In : Journal of Clinical Oncology. 23, 6, p. 1312-1314 3 p.

Research output: Contribution to journalArticle

17 Scopus citations
2006

A rapid and sensitive enzymatic method for epidermal growth factor receptor mutation screening

Jänne, P. A., Borras, A. M., Kuang, Y., Rogers, A. M., Joshi, V. A., Liyanage, H., Lindeman, N., Lee, J. C., Halmos, B., Maher, E. A., Distel, R. J., Meyerson, M. & Johnson, B. E., Feb 1 2006, In : Clinical Cancer Research. 12, 3 I, p. 751-758 8 p.

Research output: Contribution to journalArticle

186 Scopus citations

C/EBPα mutations in lung cancer

Costa, D. B., Dayaram, T., D'Alo, F., Wouters, B. J., Tenen, D. G., Meyerson, M., Tsao, M. S. & Halmos, B., Aug 1 2006, In : Lung Cancer. 53, 2, p. 253-254 2 p.

Research output: Contribution to journalLetter

14 Scopus citations

Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib

Jackman, D. M., Yeap, B. Y., Sequist, L. V., Lindeman, N., Holmes, A. J., Joshi, V. A., Bell, D. W., Huberman, M. S., Halmos, B., Rabin, M. S., Haber, D. A., Lynch, T. J., Meyerson, M., Johnson, B. E. & Jänne, P. A., Jul 1 2006, In : Clinical Cancer Research. 12, 13, p. 3908-3914 7 p.

Research output: Contribution to journalArticle

455 Scopus citations

Multiple positron-emission tomography false positives in a patient with malignant melanoma [5]

Cho, D., Kocher, O., Parker, J. A. & Halmos, B., Feb 1 2006, In : Clinical Oncology. 18, 1, p. 87-88 2 p.

Research output: Contribution to journalLetter

2 Scopus citations

Phase II trial of sequential chemotherapy followed by chemoradiation, surgery, and postoperative chemotherapy for the treatment of stage IIIA/IIIB non-small-cell lung cancer

Lam, P., Berman, S., Thurer, R., Ashiku, S., DeCamp, M., Goldstein, M., Schumer, S., Halmos, B., Karp, D., Coute, D., Bergman, M., Boyd-Sirard, C., Ou, S. H., Muzikansky, A., Woodard, C. & Huberman, M., Sep 2006, In : Clinical lung cancer. 8, 2, p. 122-129 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPα in mice

Bassères, D. S., Levantini, E., Ji, H., Monti, S., Elf, S., Dayaram, T., Fenyus, M., Kocher, O., Golub, T., Wong, K. K., Halmos, B. & Tenen, D. G., Feb 1 2006, In : Molecular and cellular biology. 26, 3, p. 1109-1123 15 p.

Research output: Contribution to journalArticle

51 Scopus citations

Three-dimensional magnetic resonance microscopy of pulmonary solitary tumors in transgenic mice

Kubo, S., Levantini, E., Kobayashi, S., Kocher, O., Halmos, B., Tenen, D. G. & Takahashi, M., Sep 1 2006, In : Magnetic Resonance in Medicine. 56, 3, p. 698-703 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling

Kobayashi, S., Shimamura, T., Monti, S., Steidl, U., Hetherington, C. J., Lowell, A. M., Golub, T., Meyerson, M., Tenen, D. G., Shapiro, G. L. & Halmos, B., Dec 1 2006, In : Cancer Research. 66, 23, p. 11389-11398 10 p.

Research output: Contribution to journalArticle

87 Scopus citations
2007

BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations

Costa, D. B., Halmos, B., Kumar, A., Schumer, S. T., Huberman, M. S., Boggon, T. J., Tenen, D. G. & Kobayashi, S., Oct 1 2007, In : PLoS Medicine. 4, 10, p. 1669-1680 12 p.

Research output: Contribution to journalArticle

373 Scopus citations

Immunohistochemical analysis of C/EBPα in non-small cell lung cancer reveals frequent down-regulation in stage II and IIIA tumors: A correlative study of E3590

Costa, D. B., Li, S., Kocher, O., Feins, R. H., Keller, S. M., Schiller, J. H., Johnson, D. H., Tenen, D. G. & Halmos, B., Apr 1 2007, In : Lung Cancer. 56, 1, p. 97-103 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies

Yu, Z., Boggon, T. J., Kobayashi, S., Jin, C., Ma, P. C., Dowlati, A., Kern, J. A., Tenen, D. G. & Halmos, B., Nov 1 2007, In : Cancer Research. 67, 21, p. 10417-10427 11 p.

Research output: Contribution to journalArticle

47 Scopus citations
2008

15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3β and a tumor suppressor in lung cancer

Huang, G., Eisenberg, R., Yan, M., Monti, S., Lawrence, E., Fu, P., Walbroehl, J., Löwenberg, E., Golub, T., Merchan, J., Tenen, D. G., Markowitz, S. D. & Halmos, B., Jul 1 2008, In : Cancer Research. 68, 13, p. 5040-5048 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer

Tang, Z., Du, R., Jiang, S., Wu, C., Barkauskas, D. S., Richey, J., Molter, J., Lam, M., Flask, C., Gerson, S., Dowlati, A., Liu, L., Lee, Z., Halmos, B., Wang, Y., Kern, J. A. & Ma, P. C., Sep 16 2008, In : British Journal of Cancer. 99, 6, p. 911-922 12 p.

Research output: Contribution to journalArticle

140 Scopus citations

Effects of erlotinib in EGFR mutated non-small cell lung cancers with resistance to gefitinib

Costa, D. B., Nguyen, K. S. H., Cho, B. C., Sequist, L. V., Jackman, D. M., Riely, G. J., Yeap, B. Y., Halmos, B., Kim, J. H., Jänne, P. A., Huberman, M. S., Pao, W., Tenen, D. G. & Kobayashi, S., Nov 1 2008, In : Clinical Cancer Research. 14, 21, p. 7060-7067 8 p.

Research output: Contribution to journalArticle

146 Scopus citations
14 Scopus citations

Structure and clinical relevance of the epidermal growth factor receptor in human cancer

Kumar, A., Petri, E. T., Halmos, B. & Boggon, T. J., Sep 15 2008, In : Journal of Clinical Oncology. 26, 10, p. 1742-1751 10 p.

Research output: Contribution to journalReview article

192 Scopus citations
2009

A randomized phase 2 study of erlotinib alone and in combination with bortezomib in previously treated advanced non-small cell lung cancer

Lynch, T. J., Fenton, D., Hirsh, V., Bodkin, D., Middleman, E. L., Chiappori, A., Halmos, B., Favis, R., Liu, H., Trepicchio, W. L., Eton, O. & Shepherd, F. A., Aug 2009, In : Journal of Thoracic Oncology. 4, 8, p. 1002-1009 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Combined vascular endothelial growth factor receptor and Epidermal Growth Factor Receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance

Naumov, G. N., Nilsson, M. B., Cascone, T., Briggs, A., Straume, O., Akslen, L. A., Lifshits, E., Byers, L. A., Xu, L., Wu, H. K., Jänne, P., Kobayashi, S., Halmos, B., Tenen, D., Tang, X. M., Engelman, J., Yeap, B., Folkman, J., Johnson, B. E. & Heymach, J. V., May 15 2009, In : Clinical Cancer Research. 15, 10, p. 3484-3494 11 p.

Research output: Contribution to journalArticle

203 Scopus citations

Cooperative interaction between protein inhibitor of activated signal transducer and activator of transcription-3 with epidermal growth factor receptor blockade in lung cancer

Kluge, A., Dabir, S., Kern, J., Nethery, D., Halmos, B., Ma, P. & Dowlati, A., Oct 1 2009, In : International Journal of Cancer. 125, 7, p. 1728-1734 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

CTCs - Ready to take center stage?

Halmos, B., Jul 1 2009, In : American Journal of Hematology/ Oncology. 8, 7

Research output: Contribution to journalComment/debate

Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity

Tang, Z., Jiang, S., Du, R., Petri, E. T., El-Telbany, A., Chan, P. S. O., Kijima, T., Dietrich, S., Matsui, K., Kobayashi, M., Sasada, S., Okamoto, N., Suzuki, H., Kawahara, K., Iwasaki, T., Nakagawa, K., Kawase, I., Christensen, J. G., Hirashima, T., Halmos, B. & 4 others, Salgia, R., Boggon, T. J., Kern, J. A. & Ma, P. C., Jan 29 2009, In : Oncogene. 28, 4, p. 518-533 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Dysregulation of the C/EBPα differentiation pathway in human cancer

Koschmieder, S., Halmos, B., Levantini, E. & Tenen, D. G., Feb 1 2009, In : Journal of Clinical Oncology. 27, 4, p. 619-628 10 p.

Research output: Contribution to journalReview article

140 Scopus citations

Genetic abnormalities of the EGFR pathway in African American patients with non-small-cell lung cancer

Leidner, R. S., Fu, P., Clifford, B., Hamdan, A., Jin, C., Eisenberg, R., Boggon, T. J., SkokanM., M., Franklin, W. A., Cappuzzo, F., Hirsch, F. R., Varella-Garcia, M. & Halmos, B., Nov 20 2009, In : Journal of Clinical Oncology. 27, 33, p. 5620-5626 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Predictive markers of esophageal cancer-in search of the main charAKTers

Leidner, R. S., LaFramboise, T. & Halmos, B., Sep 1 2009, In : American Journal of Hematology/ Oncology. 8, 9

Research output: Contribution to journalComment/debate

2010

CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells

O'Brien, K. B., Alberich-Jordà, M., Yadav, N., Kocher, O., DiRuscio, A., Ebralidze, A., Levantini, E., Sng, N. J. L., Bhasin, M., Caron, T., Kim, D., Steidl, U., Huang, G., Halmos, B., Rodig, S. J., Bedford, M. T., Tenen, D. G. & Kobayashi, S., Jul 1 2010, In : Development. 137, 13, p. 2147-2156 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells

Zhang, Z., Kobayashi, S., Borczuk, A. C., Leidner, R. S., LaFramboise, T., Levine, A. D. & Halmos, B., Jan 22 2010, In : Carcinogenesis. 31, 4, p. 577-586 10 p.

Research output: Contribution to journalArticle

111 Scopus citations

EGFR-mutated lung cancer: a paradigm of molecular oncology.

Zhang, Z., Stiegler, A. L., Boggon, T. J., Kobayashi, S. & Halmos, B., Nov 2010, In : Oncotarget. 1, 7, p. 497-514 18 p.

Research output: Contribution to journalReview article

Open Access
140 Scopus citations

Molecular testing in lung cancer: The time is now

Cheng, H., Xu, X., Costa, D. B., Powell, C. A. & Halmos, B., Sep 1 2010, In : Current oncology reports. 12, 5, p. 335-348 14 p.

Research output: Contribution to journalReview article

17 Scopus citations
2011

MET-independent lung cancer cells evading EGFR kinase inhibitors are therapeutically susceptible to BH3 mimetic agents

Fan, W., Tang, Z., Yin, L., Morrison, B., Hafez-Khayyata, S., Fu, P., Huang, H., Bagai, R., Jiang, S., Kresak, A., Howell, S., Vasanji, A., Flask, C. A., Halmos, B., Koon, H. & Ma, P. C., Jul 1 2011, In : Cancer Research. 71, 13, p. 4494-4505 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Update in lung cancer and oncological disorders 2010

Halmos, B. & Powell, C. A., Aug 1 2011, In : American Journal of Respiratory and Critical Care Medicine. 184, 3, p. 297-302 6 p.

Research output: Contribution to journalReview article

6 Scopus citations
2012

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

Zhang, Z., Lee, J. C., Lin, L., Olivas, V., Au, V., Laframboise, T., Abdel-Rahman, M., Wang, X., Levine, A. D., Rho, J. K., Choi, Y. J., Choi, C. M., Kim, S. W., Jang, S. J., Park, Y. S., Kim, W. S., Lee, D. H., Lee, J. S., Miller, V. A., Arcila, M. & 10 others, Ladanyi, M., Moonsamy, P., Sawyers, C., Boggon, T. J., Ma, P. C., Costa, C., Taron, M., Rosell, R., Halmos, B. & Bivona, T. G., Aug 1 2012, In : Nature Genetics. 44, 8, p. 852-860 9 p.

Research output: Contribution to journalArticle

685 Scopus citations

Cancer: Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers

Katayama, R., Shaw, A. T., Khan, T. M., Mino-Kenudson, M., Solomon, B. J., Halmos, B., Jessop, N. A., Wain, J. C., Yeo, A. T., Benes, C., Drew, L., Saeh, J. C., Crosby, K., Sequist, L. V., Iafrate, A. J. & Engelman, J. A., Feb 8 2012, In : Science translational medicine. 4, 120

Research output: Contribution to journalArticle

840 Scopus citations