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Publications 1990 2019

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2019
3 Citations (Scopus)

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

Hernandez, I., Luna, G., Rauch, J. N., Reis, S. A., Giroux, M., Karch, C. M., Boctor, D., Sibih, Y. E., Storm, N. J., Diaz, A., Kaushik, S., Zekanowski, C., Kang, A. A., Hinman, C. R., Cerovac, V., Guzman, E., Zhou, H., Haggarty, S. J., Goate, A. M., Fisher, S. K. & 2 others, Cuervo, A. M. & Kosik, K. S., Jan 1 2019, In : Science Translational Medicine. 11, 485

Research output: Contribution to journalArticle

Tauopathies
Farnesyltranstransferase
Lysosomes
Pathology
Brain

Age- And stress-associated C. Elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response

Butler, V. J., Gao, F., Corrales, C. I., Cortopassi, W. A., Caballero, B., Vohra, M., Ashrafi, K., Cuervo, A. M., Jacobson, M. P., Coppola, G. & Kao, A. W., Jan 1 2019, In : PLoS genetics. 15, 8, e1008295.

Research output: Contribution to journalArticle

Open Access
Caenorhabditis elegans
homeostasis
protein
proteinases
neurodegenerative diseases

Chaperone-mediated autophagy upregulation rescues megalin expression and localization in cystinotic proximal tubule cells

Zhang, J., He, J., Johnson, J. L., Rahman, F., Gavathiotis, E., Cuervo, A. M. & Catz, S. D., Jan 1 2019, In : Frontiers in Endocrinology. 10, 00021.

Research output: Contribution to journalArticle

Open Access
Low Density Lipoprotein Receptor-Related Protein-2
Autophagy
Up-Regulation
Factor IX
Cystinosis
2 Citations (Scopus)

Glioblastoma ablates pericytes antitumor immune function through aberrant up-regulation of chaperone-mediated autophagy

Valdor, R., García-Bernal, D., Riquelme, D., Martinez, C. M., Moraleda, J. M., Cuervo, A. M., Macian, F. & Martinez, S., Oct 8 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20655-20665 11 p.

Research output: Contribution to journalArticle

Open Access
Pericytes
Autophagy
Glioblastoma
Up-Regulation
Neoplasms
7 Citations (Scopus)

Lysosomal dysfunction in down syndrome is app-dependent and mediated by APP-βCTF (c99)

Jiang, Y., Sato, Y., Im, E., Berg, M., Bordi, M., Darji, S., Kumar, A., Mohan, P. S., Bandyopadhyay, U., Diaz, A., Cuervo, A. M. & Nixon, R. A., Jul 3 2019, In : Journal of Neuroscience. 39, 27, p. 5255-5268 14 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Down Syndrome
Lysosomes
Alzheimer Disease
Hydrolases
20 Citations (Scopus)

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

di Domenico, A., Carola, G., Calatayud, C., Pons-Espinal, M., Muñoz, J. P., Richaud-Patin, Y., Fernandez-Carasa, I., Gut, M., Faella, A., Parameswaran, J., Soriano, J., Ferrer, I., Tolosa, E., Zorzano, A., Cuervo, A. M., Raya, A. & Consiglio, A., Feb 12 2019, In : Stem Cell Reports. 12, 2, p. 213-229 17 p.

Research output: Contribution to journalArticle

Open Access
Astrocytes
Parkinson Disease
Synucleins
Neurons
Dopaminergic Neurons
1 Citation (Scopus)

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs

Kirchner, P., Bourdenx, M., Madrigal-Matute, J., Tiano, S., Diaz, A., Bartholdy, B. A., Will, B. & Cuervo, A. M., May 1 2019, In : PLoS biology. 17, 5, p. e3000301

Research output: Contribution to journalArticle

Open Access
autophagy
Autophagy
Proteome
proteome
Amino Acid Motifs

The negative effect of lipid challenge on autophagy inhibits T cell responses

Guerrero-Ros, I., Clement, C. C., Reynolds, C. A., Patel, B., Santambrogio, L., Cuervo, A. M. & Macian-Juan, F., Jan 1 2019, In : Autophagy.

Research output: Contribution to journalArticle

Autophagy
T-Lymphocytes
Lipids
Mitogen-Activated Protein Kinase 8
Mitogen-Activated Protein Kinase 3
2018
10 Citations (Scopus)

Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

Lee, Y. A., Noon, L. A., Akat, K. M., Ybanez, M. D., Lee, T. F., Berres, M. L., Fujiwara, N., Goossens, N., Chou, H. I., Parvin-Nejad, F. P., Khambu, B., Kramer, E. G. M., Gordon, R., Pfleger, C., Germain, D., John, G. R., Campbell, K. N., Yue, Z., Yin, X. M., Cuervo, A. M. & 4 others, Czaja, M. J., Fiel, M. I., Hoshida, Y. & Friedman, S. L., Dec 1 2018, In : Nature Communications. 9, 1, 4962.

Research output: Contribution to journalArticle

Open Access
Autophagy
liver
Liver
Carcinogenesis
degradation
7 Citations (Scopus)

Autophagy is required for sortilin-mediated degradation of apolipoprotein B100

Amengual, J., Guo, L., Strong, A., Madrigal-Matute, J., Wang, H., Kaushik, S., Brodsky, J. L., Rader, D. J., Cuervo, A. M. & Fisher, E. A., Feb 1 2018, In : Circulation Research. 122, 4, p. 568-582 15 p.

Research output: Contribution to journalArticle

Apolipoproteins
Autophagy
Apolipoproteins B
LDL Cholesterol
Lysosomes
17 Citations (Scopus)

Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD

Schultz, M. L., Krus, K. L., Kaushik, S., Dang, D., Chopra, R., Qi, L., Shakkottai, V. G., Cuervo, A. M. & Lieberman, A. P., Dec 1 2018, In : Nature Communications. 9, 1, 3671.

Research output: Contribution to journalArticle

Autophagy
degradation
Degradation
machinery
Proteasome Endopeptidase Complex
12 Citations (Scopus)

Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging

Bejarano, E., Murray, J. W., Wang, X., Pampliega, O., Yin, D., Patel, B., Yuste, A., Wolkoff, A. W. & Cuervo, A. M., Jan 1 2018, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

Autophagy
Lysosomes
Proteins
Dyneins
Microtubules
17 Citations (Scopus)

Humanin is an endogenous activator of chaperonemediated autophagy

Gong, Z., Tasset, I., Diaz, A., Anguiano, J., Tas, E., Cui, L., Kuliawat, R., Liu, H., Kühn, B., Cuervo, A. M. & Muzumdar, R., Feb 1 2018, In : Journal of Cell Biology. 217, 2, p. 635-647 13 p.

Research output: Contribution to journalArticle

Autophagy
HSP90 Heat-Shock Proteins
Neuroprotective Agents
Lysosomes
Membranes
150 Citations (Scopus)

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

Zhang, H., Freitas, D., Kim, H. S., Fabijanic, K., Li, Z., Chen, H., Mark, M. T., Molina, H., Martin, A. B., Bojmar, L., Fang, J., Rampersaud, S., Hoshino, A., Matei, I., Kenific, C. M., Nakajima, M., Mutvei, A. P., Sansone, P., Buehring, W., Wang, H. & 22 others, Jimenez, J. P., Cohen-Gould, L., Paknejad, N., Brendel, M., Manova-Todorova, K., Magalhães, A., Ferreira, J. A., Osório, H., Silva, A. M., Massey, A., Cubillos-Ruiz, J. R., Galletti, G., Giannakakou, P., Cuervo, A. M., Blenis, J., Schwartz, R., Brady, M. S., Peinado, H., Bromberg, J., Matsui, H., Reis, C. A. & Lyden, D., Mar 1 2018, In : Nature Cell Biology. 20, 3, p. 332-343 12 p.

Research output: Contribution to journalArticle

Field Flow Fractionation
Exosomes
Nanoparticles
Microtubule Proteins
Spindle Apparatus
1 Citation (Scopus)

Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons

Bayó-Puxan, N., Terrasso, A. P., Creyssels, S., Simão, D., Begon-Pescia, C., Lavigne, M., Salinas, S., Bernex, F., Bosch, A., Kalatzis, V., Levade, T., Cuervo, A. M., Lory, P., Consiglio, A., Brito, C. & Kremer, E. J., Dec 1 2018, In : Scientific Reports. 8, 1, 16644.

Research output: Contribution to journalArticle

Mucopolysaccharidosis VII
Neurons
Glycosaminoglycans
Phenotype
Mucopolysaccharidosis I
16 Citations (Scopus)

Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans

Theofilas, P., Ehrenberg, A. J., Nguy, A., Thackrey, J. M., Dunlop, S., Mejia, M. B., Alho, A. T., Paraizo Leite, R. E., Rodriguez, R. D., Suemoto, C. K., Nascimento, C. F., Chin, M., Medina-Cleghorn, D., Cuervo, A. M., Arkin, M., Seeley, W. W., Miller, B. L., Nitrini, R., Pasqualucci, C. A., Filho, W. J. & 4 others, Rueb, U., Neuhaus, J., Heinsen, H. & Grinberg, L. T., Jan 1 2018, In : Neurobiology of Aging. 61, p. 1-12 12 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Alzheimer Disease
Cell Death
Autophagy
Caspases
2 Citations (Scopus)

Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia

Geier, E. G., Bourdenx, M., Storm, N. J., Cochran, J. N., Sirkis, D. W., Hwang, J. H., Bonham, L. W., Ramos, E. M., Diaz, A., Van Berlo, V., Dokuru, D., Nana, A. L., Karydas, A., Balestra, M. E., Huang, Y., Russo, S. P., Spina, S., Grinberg, L. T., Seeley, W. W., Myers, R. M. & 5 others, Miller, B. L., Coppola, G., Lee, S. E., Cuervo, A. M. & Yokoyama, J. S., Jan 1 2018, (Accepted/In press) In : Acta Neuropathologica.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Neuronal Ceroid-Lipofuscinoses
Frontotemporal Dementia
Genes
Mutation
2 Citations (Scopus)

Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans

Walters, R. O., Arias-Perez, E., Diaz, A., Burgos, E. S., Guan, F., Tiano, S., Mao, K., Green, C. L., Qiu, Y., Shah, H., Wang, D., Hudgins, A. D., Tabrizian, T., Tosti, V., Shechter, D., Fontana, L., Kurland, I. J., Barzilai, N., Cuervo, A. M., Promislow, D. E. L. & 1 others, Huffman, D. M., Oct 16 2018, In : Cell Reports. 25, 3, p. 663-676.e6

Research output: Contribution to journalArticle

Sarcosine
Rodentia
Aging of materials
Metabolome
Autophagy
89 Citations (Scopus)

The coming of age of chaperone-mediated autophagy

Kaushik, S. & Cuervo, A. M., Apr 6 2018, (Accepted/In press) In : Nature Reviews Molecular Cell Biology. p. 1-17 17 p.

Research output: Contribution to journalArticle

Autophagy
Lysosomes
Lysosome-Associated Membrane Glycoproteins
Lipid Metabolism
DNA Repair
6 Citations (Scopus)

The ULK1-FBXW5-SEC23B nexus controls autophagy

Jeong, Y. T., Simoneschi, D., Keegan, S., Melville, D., Adler, N. S., Saraf, A., Florens, L., Washburn, M. P., Cavasotto, C. N., Fenyö, D., Cuervo, A. M., Rossi, M. & Pagano, M., Dec 1 2018, In : eLife. 7, e42253.

Research output: Contribution to journalArticle

Open Access
Autophagy
Nutrients
Capsid Proteins
Food
Starvation
19 Citations (Scopus)

Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A

Pajares, M., Rojo, A. I., Arias-Perez, E., Díaz-Carretero, A., Cuervo, A. M. & Cuadrado, A., Jan 1 2018, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

Autophagy
Transcription Factors
Lysosome-Associated Membrane Glycoproteins
Basic-Leucine Zipper Transcription Factors
Paraquat
2017
24 Citations (Scopus)

Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation

Gomes, L. R., Menck, C. F. M. & Cuervo, A. M., May 4 2017, In : Autophagy. 13, 5, p. 928-940 13 p.

Research output: Contribution to journalArticle

Autophagy
Ubiquitination
Neoplasms
Oncogenes
Phosphoric Monoester Hydrolases
17 Citations (Scopus)

Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A

Zhang, J., Johnson, J. L., He, J., Napolitano, G., Ramadass, M., Rocca, C., Kiosses, W. B., Bucci, C., Xin, Q., Gavathiotis, E., Cuervo, A. M., Cherqui, S. & Catz, S. D., 2017, In : Journal of Biological Chemistry. 292, 25, p. 10328-10346 19 p.

Research output: Contribution to journalArticle

Cystinosis
Monomeric GTP-Binding Proteins
Autophagy
Transcription Factors
Cystine
29 Citations (Scopus)

Interplay of pathogenic forms of human tau with different autophagic pathways

Caballero, B., Wang, Y., Diaz, A., Tasset, I., Juste, Y. R., Mandelkow, E. M., Mandelkow, E. & Cuervo, A. M., 2017, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

Autophagy
Mutation
Tauopathies
Microtubule Proteins
tau Proteins
59 Citations (Scopus)

Programmed mitophagy is essential for the glycolytic switch during cell differentiation

Esteban-Martínez, L., Sierra-Filardi, E., Estrada, R. S., Salazar-Roa, M., Mariño, G., Seco, E., Durand, S., Enot, D., Graña, O., Malumbres, M., Cvekl, A., Cuervo, A. M., Kroemer, G. & Boya, P., Jun 14 2017, In : EMBO Journal. 36, 12, p. 1688-1706 19 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Mitochondria
Retinal Ganglion Cells
Macrophages
Cell Differentiation
44 Citations (Scopus)

Store-Operated Ca2+ Entry Controls Induction of Lipolysis and the Transcriptional Reprogramming to Lipid Metabolism

Maus, M., Cuk, M., Patel, B., Lian, J., Ouimet, M., Kaufmann, U., Yang, J., Horvath, R., Hornig-Do, H. T., Chrzanowska-Lightowlers, Z. M., Moore, K. J., Cuervo, A. M. & Feske, S., Mar 7 2017, In : Cell Metabolism. 25, 3, p. 698-712 15 p.

Research output: Contribution to journalArticle

Lipolysis
Lipid Metabolism
Fatty Acids
Peroxisome Proliferator-Activated Receptors
Lipase
97 Citations (Scopus)

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

Beckerman, P., Bi-Karchin, J., Park, A. S. D., Qiu, C., Dummer, P. D., Soomro, I., Boustany-Kari, C. M., Pullen, S. S., Miner, J. H., Hu, C. A. A., Rohacs, T., Inoue, K., Ishibe, S., Saleem, M. A., Palmer, M. B., Cuervo, A. M., Kopp, J. B. & Susztak, K., Apr 1 2017, In : Nature Medicine. 23, 4, p. 429-438 10 p.

Research output: Contribution to journalArticle

Podocytes
Kidney Diseases
Alleles
Genes
Azotemia
2016
56 Citations (Scopus)

AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA

Kaushik, S. & Cuervo, A. M., Jan 1 2016, In : Autophagy. 12, 2, p. 432-438 7 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Autophagy
Phosphorylation
Lipolysis
Lipase
30 Citations (Scopus)

Autophagy and primary cilia: Dual interplay

Pampliega, O. & Cuervo, A. M., Apr 1 2016, In : Current Opinion in Cell Biology. 39, p. 1-7 7 p.

Research output: Contribution to journalArticle

Cilia
Autophagy
Lysosomes
Microtubules
Organelles
109 Citations (Scopus)

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., González-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., Wahl, D., Ali, A., Calvo-Rubio, M., Burón, M. I., Guiterrez, V., Ward, T. M., Palacios, H. H., Cai, H., Frederick, D. W., Hine, C. & 27 others, Broeskamp, F., Habering, L., Dawson, J., Beasley, T. M., Wan, J., Ikeno, Y., Hubbard, G., Becker, K. G., Zhang, Y., Bohr, V. A., Longo, D. L., Navas, P., Ferrucci, L., Sinclair, D. A., Cohen, P., Egan, J. M., Mitchell, J. R., Baur, J. A., Allison, D. B., Anson, R. M., Villalba, J. M., Madeo, F., Cuervo, A. M., Pearson, K. J., Ingram, D. K., Bernier, M. & De Cabo, R., Jun 14 2016, In : Cell Metabolism. 23, 6, p. 1093-1112 20 p.

Research output: Contribution to journalArticle

Energy Intake
Health
Metabolomics
Citric Acid Cycle
Survival
14 Citations (Scopus)

Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis

Champa, D., Orlacchio, A., Patel, B., Ranieri, M., Shemetov, A., Verkhusha, V., Cuervo, A. M. & Di Cristofano, A., Jun 7 2016, In : Oncotarget. 7, 23, p. 34453-34471 19 p.

Research output: Contribution to journalArticle

Lysosomes
Necrosis
Thyroid Neoplasms
Mefloquine
Neoplasms
101 Citations (Scopus)

Regulation of Liver Metabolism by Autophagy

Madrigal-Matute, J. & Cuervo, A. M., Feb 1 2016, In : Gastroenterology. 150, 2, p. 328-339 12 p.

Research output: Contribution to journalArticle

Autophagy
Liver
Essential Amino Acids
Metabolic Diseases
Recycling
29 Citations (Scopus)

Selective endosomal microautophagy is starvation-inducible in Drosophila

Mukherjee, A., Patel, B., Koga, H., Cuervo, A. M. & Jenny, A., Nov 1 2016, (Accepted/In press) In : Autophagy. p. 1-16 16 p.

Research output: Contribution to journalArticle

Autophagy
Starvation
Drosophila
Diptera
Biosensing Techniques
29 Citations (Scopus)

Selective endosomal microautophagy is starvation inducible in Drosophila.

Mukherjee, A., Patel, B., Koga, H., Cuervo, A. M. & Jenny, A., 2016, In : Autophagy.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Structural and biological interaction of HSC-70 protein with phosphatidylserine in endosomal microautophagy

Morozova, K., Clement, C. C., Kaushik, S., Stiller, B., Arias, E., Ahmad, A., Rauch, J. N., Chatterjee, V., Melis, C., Scharf, B., Gestwicki, J. E., Cuervo, A. M., Zuiderweg, E. R. P. & Santambrogio, L., Aug 26 2016, In : Journal of Biological Chemistry. 291, 35, p. 18096-18106 11 p.

Research output: Contribution to journalArticle

Phosphatidylserines
Autophagy
Proteins
Protein Refolding
Membranes
2015
18 Citations (Scopus)

Annexin A2 promotes phagophore assembly by enhancing Atg16L+ vesicle biogenesis and homotypic fusion

Morozova, K., Sidhar, S., Zolla, V., Clement, C. C., Scharf, B., Verzani, Z., Diaz, A., Larocca, J. N., Hajjar, K. A., Cuervo, A. M. & Santambrogio, L., 2015, In : Nature Communications. 6, 5856.

Research output: Contribution to journalArticle

Annexin A2
biological evolution
Fusion reactions
assembly
fusion
3 Citations (Scopus)

Corrigendum: Annexin A2 promotes phagophore assembly by enhancing Atg16<sup>+</sup> vesicle biogenesis and homotypic fusion

Morozova, K., Sridhar, S., Zolla, V., Clement, C. C., Scharf, B., Verzani, Z., Diaz, A., Larocca, J. N., Hajjar, K. A., Cuervo, A. M. & Santambrogio, L., 2015, In : Nature Communications. 6, 6816.

Research output: Contribution to journalArticle

Annexin A2
biological evolution
assembly
fusion
corrigendum
176 Citations (Scopus)

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

Kaushik, S. & Cuervo, A. M., Jun 1 2015, In : Nature Cell Biology. 17, 6, p. 759-770 12 p.

Research output: Contribution to journalArticle

Lipolysis
Autophagy
Lipase
Lipids
Lipid Droplet Associated Proteins
15 Citations (Scopus)

HTT/Huntingtin in selective autophagy and Huntington disease: A foe or a friend within?

Rui, Y. N., Xu, Z., Patel, B., Cuervo, A. M. & Zhang, S., Jan 1 2015, In : Autophagy. 11, 5, p. 858-860 3 p.

Research output: Contribution to journalArticle

Nerve Tissue Proteins
Mitochondrial Degradation
Biological Models
Huntington Disease
Autophagy
155 Citations (Scopus)

Huntingtin functions as a scaffold for selective macroautophagy

Rui, Y. N., Xu, Z., Patel, B., Chen, Z., Chen, D., Tito, A., David, G., Sun, Y., Stimming, E. F., Bellen, H. J., Cuervo, A. M. & Zhang, S., Mar 2 2015, In : Nature Cell Biology. 17, 3, p. 262-275 14 p.

Research output: Contribution to journalArticle

Autophagy
Aptitude
Huntington Disease
Ubiquitin
Starvation
2 Citations (Scopus)

Hydrodynamic size-based separation and characterization of protein aggregates from total cell lysates

Tanase, M., Zolla, V., Clement, C. C., Borghi, F., Urbanska, A. M., Rodriguez-Navarro, J. A., Roda, B., Zattoni, A., Reschiglian, P., Cuervo, A. M. & Santambrogio, L., Jan 1 2015, In : Nature Protocols. 10, 1, p. 134-148 15 p.

Research output: Contribution to journalArticle

Hydrodynamics
Fractionation
Field Flow Fractionation
Molecular Weight
Light scattering
59 Citations (Scopus)

Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging

Schneider, J. L., Villarroya, J., Diaz-Carretero, A., Patel, B., Urbanska, A. M., Thi, M. M., Villarroya, F., Santambrogio, L. & Cuervo, A. M., Apr 1 2015, In : Aging Cell. 14, 2, p. 249-264 16 p.

Research output: Contribution to journalArticle

Autophagy
Liver
Proteins
Oxidative Stress
Homeostasis
92 Citations (Scopus)

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy

Arias-Perez, E., Koga, H., Diaz, A., Mocholi, E., Patel, B. & Cuervo, A. M., Jul 16 2015, In : Molecular Cell. 59, 2, p. 270-284 15 p.

Research output: Contribution to journalArticle

Autophagy
Phosphoric Monoester Hydrolases
Membranes
TOR complex 2
Lysosomes
26 Citations (Scopus)

Methods to study chaperone-mediated autophagy

Patel, B. & Cuervo, A. M., Mar 15 2015, In : Methods. 75, p. 133-140 8 p.

Research output: Contribution to journalArticle

Autophagy
Recycling
Pathology
Proteome
Medical problems
31 Citations (Scopus)

Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide

Macri, C., Wang, F., Tasset, I., Schall, N., Page, N., Briand, J. P., Cuervo, A. M. & Muller, S., Jan 1 2015, In : Autophagy. 11, 3, p. 472-486 15 p.

Research output: Contribution to journalArticle

Phosphopeptides
Autophagy
B-Lymphocytes
Down-Regulation
Phosphoserine
212 Citations (Scopus)

Proteostasis and aging

Kaushik, S. & Cuervo, A. M., Dec 8 2015, In : Nature Medicine. 21, 12, p. 1406-1415 10 p.

Research output: Contribution to journalArticle

Aging of materials
Homeostasis
Proteins
Cell Aging
Proteome

Reflections on the field of metabolism

Moller, D. E., Cuervo, A. M., Gordon, J., Froguel, P. & Mangelsdorf, D. J., Apr 7 2015, In : Cell Metabolism. 21, 4, p. 505-506 2 p.

Research output: Contribution to journalArticle

Biochemistry
75 Citations (Scopus)

Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage

Park, C., Suh, Y. & Cuervo, A. M., Apr 16 2015, In : Nature Communications. 6, 6823.

Research output: Contribution to journalArticle

genome
Autophagy
DNA Damage
Phosphotransferases
deoxyribonucleic acid
8 Citations (Scopus)

Selective autophagy and Huntingtin: Learning from disease

Cuervo, A. M. & Zhang, S., Jan 1 2015, In : Cell Cycle. 14, 11, p. 1617-1618 2 p.

Research output: Contribution to journalArticle

Signal Transducing Adaptor Proteins
Nerve Tissue Proteins
Intracellular Signaling Peptides and Proteins
Biological Models
Phagosomes
18 Citations (Scopus)

The role of autophagy in liver diseases: Mechanisms and potential therapeutic targets

Cursio, R., Colosetti, P., Codogno, P., Cuervo, A. M. & Shen, H. M., 2015, In : BioMed Research International. 2015, 480508.

Research output: Contribution to journalArticle

Liver
Animals