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1990 …2020

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2020

Cav-1 (Caveolin-1) Deficiency Increases Autophagy in the Endothelium and Attenuates Vascular Inflammation and Atherosclerosis

Zhang, X., Ramírez, C. M., Aryal, B., Madrigal-Matute, J., Liu, X., Diaz, A., Torrecilla-Parra, M., Suárez, Y., Cuervo, A. M., Sessa, W. C. & Fernández-Hernando, C., 2020, (Accepted/In press) In : Arteriosclerosis, thrombosis, and vascular biology. p. 1510-1522 13 p.

Research output: Contribution to journalArticle

Open Access

Disulfiram Treatment Normalizes Body Weight in Obese Mice

Bernier, M., Mitchell, S. J., Wahl, D., Diaz, A., Singh, A., Seo, W., Wang, M., Ali, A., Kaiser, T., Price, N. L., Aon, M. A., Kim, E. Y., Petr, M. A., Cai, H., Warren, A., Di Germanio, C., Di Francesco, A., Fishbein, K., Guiterrez, V., Harney, D. & 19 others, Koay, Y. C., Mach, J., Enamorado, I. N., Pulpitel, T., Wang, Y., Zhang, J., Zhang, L., Spencer, R. G., Becker, K. G., Egan, J. M., Lakatta, E. G., O'Sullivan, J., Larance, M., LeCouteur, D. G., Cogger, V. C., Gao, B., Fernandez-Hernando, C., Cuervo, A. M. & de Cabo, R., Aug 4 2020, In : Cell metabolism. 32, 2, p. 203-214.e4

Research output: Contribution to journalArticle

Open Access

Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo

Dong, S., Aguirre-Hernandez, C., Scrivo, A., Eliscovich, C., Arias, E., Bravo-Cordero, J. J. & Cuervo, A. M., Dec 1 2020, In : Nature communications. 11, 1, 645.

Research output: Contribution to journalArticle

Open Access

PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression

Kudo, Y., Sugimoto, M., Arias, E., Kasashima, H., Cordes, T., Linares, J. F., Duran, A., Nakanishi, Y., Nakanishi, N., L'Hermitte, A., Campos, A., Senni, N., Rooslid, T., Roberts, L. R., Cuervo, A. M., Metallo, C. M., Karin, M., Diaz-Meco, M. T. & Moscat, J., Aug 10 2020, In : Cancer Cell. 38, 2, p. 247-262.e11

Research output: Contribution to journalArticle

Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy

Chen, X., Li, Y., Wang, C., Tang, Y., Mok, S. A., Tsai, R. M., Rojas, J. C., Karydas, A., Miller, B. L., Boxer, A. L., Gestwicki, J. E., Arkin, M., Cuervo, A. M. & Gan, L., Jan 6 2020, In : Molecular Neurodegeneration. 15, 1, 2.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

Hernandez, I., Luna, G., Rauch, J. N., Reis, S. A., Giroux, M., Karch, C. M., Boctor, D., Sibih, Y. E., Storm, N. J., Diaz, A., Kaushik, S., Zekanowski, C., Kang, A. A., Hinman, C. R., Cerovac, V., Guzman, E., Zhou, H., Haggarty, S. J., Goate, A. M., Fisher, S. K. & 2 others, Cuervo, A. M. & Kosik, K. S., Jan 1 2019, In : Science translational medicine. 11, 485

Research output: Contribution to journalArticle

10 Scopus citations

Age- And stress-associated C. Elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response

Butler, V. J., Gao, F., Corrales, C. I., Cortopassi, W. A., Caballero, B., Vohra, M., Ashrafi, K., Cuervo, A. M., Jacobson, M. P., Coppola, G. & Kao, A. W., 2019, In : PLoS genetics. 15, 8, e1008295.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

Bektas, A., Schurman, S. H., Gonzalez-Freire, M., Dunn, C. A., Singh, A. K., Macian, F., Cuervo, A. M., Sen, R. & Ferrucci, L., Jan 1 2019, In : Aging. 11, 21, p. 9234-9263 30 p.

Research output: Contribution to journalArticle

2 Scopus citations

Chaperone-mediated autophagy upregulation rescues megalin expression and localization in cystinotic proximal tubule cells

Zhang, J., He, J., Johnson, J. L., Rahman, F., Gavathiotis, E., Cuervo, A. M. & Catz, S. D., Jan 1 2019, In : Frontiers in Endocrinology. 10, 00021.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Glioblastoma ablates pericytes antitumor immune function through aberrant up-regulation of chaperone-mediated autophagy

Valdor, R., García-Bernal, D., Riquelme, D., Martinez, C. M., Moraleda, J. M., Cuervo, A. M., Macian, F. & Martinez, S., Oct 8 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20655-20665 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Lysosomal dysfunction in down syndrome is app-dependent and mediated by APP-βCTF (c99)

Jiang, Y., Sato, Y., Im, E., Berg, M., Bordi, M., Darji, S., Kumar, A., Mohan, P. S., Bandyopadhyay, U., Diaz, A., Cuervo, A. M. & Nixon, R. A., Jul 3 2019, In : Journal of Neuroscience. 39, 27, p. 5255-5268 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

di Domenico, A., Carola, G., Calatayud, C., Pons-Espinal, M., Muñoz, J. P., Richaud-Patin, Y., Fernandez-Carasa, I., Gut, M., Faella, A., Parameswaran, J., Soriano, J., Ferrer, I., Tolosa, E., Zorzano, A., Cuervo, A. M., Raya, A. & Consiglio, A., Feb 12 2019, In : Stem Cell Reports. 12, 2, p. 213-229 17 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs

Kirchner, P., Bourdenx, M., Madrigal-Matute, J., Tiano, S., Diaz, A., Bartholdy, B. A., Will, B. & Cuervo, A. M., May 1 2019, In : PLoS biology. 17, 5, p. e3000301

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia

Geier, E. G., Bourdenx, M., Storm, N. J., Cochran, J. N., Sirkis, D. W., Hwang, J. H., Bonham, L. W., Ramos, E. M., Diaz, A., Van Berlo, V., Dokuru, D., Nana, A. L., Karydas, A., Balestra, M. E., Huang, Y., Russo, S. P., Spina, S., Grinberg, L. T., Seeley, W. W., Myers, R. M. & 5 others, Miller, B. L., Coppola, G., Lee, S. E., Cuervo, A. M. & Yokoyama, J. S., Jan 21 2019, In : Acta neuropathologica. 137, 1, p. 71-88 18 p.

Research output: Contribution to journalArticle

3 Scopus citations

The negative effect of lipid challenge on autophagy inhibits T cell responses

Guerrero-Ros, I., Clement, C. C., Reynolds, C. A., Patel, B., Santambrogio, L., Cuervo, A. M. & Macian-Juan, F., Jan 1 2019, In : Autophagy.

Research output: Contribution to journalArticle

2018

Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

Lee, Y. A., Noon, L. A., Akat, K. M., Ybanez, M. D., Lee, T. F., Berres, M. L., Fujiwara, N., Goossens, N., Chou, H. I., Parvin-Nejad, F. P., Khambu, B., Kramer, E. G. M., Gordon, R., Pfleger, C., Germain, D., John, G. R., Campbell, K. N., Yue, Z., Yin, X. M., Cuervo, A. M. & 4 others, Czaja, M. J., Fiel, M. I., Hoshida, Y. & Friedman, S. L., Dec 1 2018, In : Nature communications. 9, 1, 4962.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Autophagy is required for sortilin-mediated degradation of apolipoprotein B100

Amengual, J., Guo, L., Strong, A., Madrigal-Matute, J., Wang, H., Kaushik, S., Brodsky, J. L., Rader, D. J., Cuervo, A. M. & Fisher, E. A., Feb 2018, In : Circulation research. 122, 4, p. 568-582 15 p.

Research output: Contribution to journalArticle

7 Scopus citations

Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD

Schultz, M. L., Krus, K. L., Kaushik, S., Dang, D., Chopra, R., Qi, L., Shakkottai, V. G., Cuervo, A. M. & Lieberman, A. P., Dec 1 2018, In : Nature communications. 9, 1, 3671.

Research output: Contribution to journalArticle

25 Scopus citations

Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging

Bejarano-Fernandez, E., Murray, J. W., Wang, X., Pampliega, O., Yin, D., Patel, B., Yuste, A., Wolkoff, A. W. & Cuervo, A. M., Aug 2018, In : Aging cell. 17, 4, e12777.

Research output: Contribution to journalArticle

13 Scopus citations

Humanin is an endogenous activator of chaperonemediated autophagy

Gong, Z., Tasset, I., Diaz, A., Anguiano, J., Tas, E., Cui, L., Kuliawat, R., Liu, H., Kühn, B., Cuervo, A. M. & Muzumdar, R., Feb 1 2018, In : Journal of Cell Biology. 217, 2, p. 635-647 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

Zhang, H., Freitas, D., Kim, H. S., Fabijanic, K., Li, Z., Chen, H., Mark, M. T., Molina, H., Martin, A. B., Bojmar, L., Fang, J., Rampersaud, S., Hoshino, A., Matei, I., Kenific, C. M., Nakajima, M., Mutvei, A. P., Sansone, P., Buehring, W., Wang, H. & 22 others, Jimenez, J. P., Cohen-Gould, L., Paknejad, N., Brendel, M., Manova-Todorova, K., Magalhães, A., Ferreira, J. A., Osório, H., Silva, A. M., Massey, A., Cubillos-Ruiz, J. R., Galletti, G., Giannakakou, P., Cuervo, A. M., Blenis, J., Schwartz, R., Brady, M. S., Peinado, H., Bromberg, J., Matsui, H., Reis, C. A. & Lyden, D., Mar 1 2018, In : Nature Cell Biology. 20, 3, p. 332-343 12 p.

Research output: Contribution to journalArticle

220 Scopus citations

Interplay of pathogenic forms of human tau with different autophagic pathways

Caballero, B., Wang, Y., Diaz, A., Tasset, I., Juste, Y. R., Stiller, B., Mandelkow, E. M., Mandelkow, E. & Cuervo, A. M., Feb 1 2018, In : Aging cell. 17, 1, e12692.

Research output: Contribution to journalArticle

36 Scopus citations

Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons

Bayó-Puxan, N., Terrasso, A. P., Creyssels, S., Simão, D., Begon-Pescia, C., Lavigne, M., Salinas, S., Bernex, F., Bosch, A., Kalatzis, V., Levade, T., Cuervo, A. M., Lory, P., Consiglio, A., Brito, C. & Kremer, E. J., Dec 1 2018, In : Scientific reports. 8, 1, 16644.

Research output: Contribution to journalArticle

1 Scopus citations

Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans

Theofilas, P., Ehrenberg, A. J., Nguy, A., Thackrey, J. M., Dunlop, S., Mejia, M. B., Alho, A. T., Paraizo Leite, R. E., Rodriguez, R. D., Suemoto, C. K., Nascimento, C. F., Chin, M., Medina-Cleghorn, D., Cuervo, A. M., Arkin, M., Seeley, W. W., Miller, B. L., Nitrini, R., Pasqualucci, C. A., Filho, W. J. & 4 others, Rueb, U., Neuhaus, J., Heinsen, H. & Grinberg, L. T., Jan 1 2018, In : Neurobiology of Aging. 61, p. 1-12 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans

Walters, R. O., Arias, E., Diaz, A., Burgos, E. S., Guan, F., Tiano, S., Mao, K., Green, C. L., Qiu, Y., Shah, H., Wang, D., Hudgins, A. D., Tabrizian, T., Tosti, V., Shechter, D., Fontana, L., Kurland, I. J., Barzilai, N., Cuervo, A. M., Promislow, D. E. L. & 1 others, Huffman, D. M., Oct 16 2018, In : Cell Reports. 25, 3, p. 663-676.e6

Research output: Contribution to journalArticle

6 Scopus citations

The coming of age of chaperone-mediated autophagy

Kaushik, S. & Cuervo, A. M., Apr 6 2018, (Accepted/In press) In : Nature Reviews Molecular Cell Biology. p. 1-17 17 p.

Research output: Contribution to journalArticle

138 Scopus citations

The ULK1-FBXW5-SEC23B nexus controls autophagy

Jeong, Y. T., Simoneschi, D., Keegan, S., Melville, D., Adler, N. S., Saraf, A., Florens, L., Washburn, M. P., Cavasotto, C. N., Fenyö, D., Cuervo, A. M., Rossi, M. & Pagano, M., Dec 1 2018, In : eLife. 7, e42253.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A

Pajares, M., Rojo, A. I., Arias, E., Díaz-Carretero, A., Cuervo, A. M. & Cuadrado, A., Aug 3 2018, In : Autophagy. 14, 8, p. 1310-1322 13 p.

Research output: Contribution to journalArticle

28 Scopus citations
2017

Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation

Gomes, L. R., Menck, C. F. M. & Cuervo, A. M., May 4 2017, In : Autophagy. 13, 5, p. 928-940 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A

Zhang, J., Johnson, J. L., He, J., Napolitano, G., Ramadass, M., Rocca, C., Kiosses, W. B., Bucci, C., Xin, Q., Gavathiotis, E., Cuervo, A. M., Cherqui, S. & Catz, S. D., Jun 23 2017, In : Journal of Biological Chemistry. 292, 25, p. 10328-10346 19 p.

Research output: Contribution to journalArticle

20 Scopus citations

Programmed mitophagy is essential for the glycolytic switch during cell differentiation

Esteban-Martínez, L., Sierra-Filardi, E., McGreal, R. S., Salazar-Roa, M., Mariño, G., Seco, E., Durand, S., Enot, D., Graña, O., Malumbres, M., Cvekl, A., Cuervo, A. M., Kroemer, G. & Boya, P., Jun 14 2017, In : EMBO Journal. 36, 12, p. 1688-1706 19 p.

Research output: Contribution to journalArticle

79 Scopus citations

Store-Operated Ca2+ Entry Controls Induction of Lipolysis and the Transcriptional Reprogramming to Lipid Metabolism

Maus, M., Cuk, M., Patel, B., Lian, J., Ouimet, M., Kaufmann, U., Yang, J., Horvath, R., Hornig-Do, H. T., Chrzanowska-Lightowlers, Z. M., Moore, K. J., Cuervo, A. M. & Feske, S., Mar 7 2017, In : Cell metabolism. 25, 3, p. 698-712 15 p.

Research output: Contribution to journalArticle

51 Scopus citations

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

Beckerman, P., Bi-Karchin, J., Park, A. S. D., Qiu, C., Dummer, P. D., Soomro, I., Boustany-Kari, C. M., Pullen, S. S., Miner, J. H., Hu, C. A. A., Rohacs, T., Inoue, K., Ishibe, S., Saleem, M. A., Palmer, M. B., Cuervo, A. M., Kopp, J. B. & Susztak, K., Apr 1 2017, In : Nature Medicine. 23, 4, p. 429-438 10 p.

Research output: Contribution to journalArticle

112 Scopus citations
2016

AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA

Kaushik, S. & Cuervo, A. M., Jan 1 2016, In : Autophagy. 12, 2, p. 432-438 7 p.

Research output: Contribution to journalArticle

67 Scopus citations

Autophagy and primary cilia: Dual interplay

Pampliega, O. & Cuervo, A. M., Apr 1 2016, In : Current Opinion in Cell Biology. 39, p. 1-7 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., González-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., Wahl, D., Ali, A., Calvo-Rubio, M., Burón, M. I., Guiterrez, V., Ward, T. M., Palacios, H. H., Cai, H., Frederick, D. W., Hine, C. & 27 others, Broeskamp, F., Habering, L., Dawson, J., Beasley, T. M., Wan, J., Ikeno, Y., Hubbard, G., Becker, K. G., Zhang, Y., Bohr, V. A., Longo, D. L., Navas, P., Ferrucci, L., Sinclair, D. A., Cohen, P., Egan, J. M., Mitchell, J. R., Baur, J. A., Allison, D. B., Anson, R. M., Villalba, J. M., Madeo, F., Cuervo, A. M., Pearson, K. J., Ingram, D. K., Bernier, M. & De Cabo, R., Jun 14 2016, In : Cell metabolism. 23, 6, p. 1093-1112 20 p.

Research output: Contribution to journalArticle

138 Scopus citations

Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis

Champa, D., Orlacchio, A., Patel, B., Ranieri, M., Shemetov, A. A., Verkhusha, V. V., Cuervo, A. M. & Di Cristofano, A., Jun 7 2016, In : Oncotarget. 7, 23, p. 34453-34471 19 p.

Research output: Contribution to journalArticle

15 Scopus citations

Regulation of Liver Metabolism by Autophagy

Madrigal-Matute, J. & Cuervo, A. M., Feb 1 2016, In : Gastroenterology. 150, 2, p. 328-339 12 p.

Research output: Contribution to journalArticle

121 Scopus citations

Selective endosomal microautophagy is starvation-inducible in Drosophila

Mukherjee, A., Patel, B., Koga, H., Cuervo, A. M. & Jenny, A., Nov 1 2016, (Accepted/In press) In : Autophagy. p. 1-16 16 p.

Research output: Contribution to journalArticle

40 Scopus citations

Selective endosomal microautophagy is starvation inducible in Drosophila.

Mukherjee, A., Patel, B., Koga, H., Cuervo, A. M. & Jenny, A., 2016, In : Autophagy.

Research output: Contribution to journalArticle

40 Scopus citations

Structural and biological interaction of HSC-70 protein with phosphatidylserine in endosomal microautophagy

Morozova, K., Clement, C. C., Kaushik, S., Stiller, B., Arias, E., Ahmad, A., Rauch, J. N., Chatterjee, V., Melis, C., Scharf, B., Gestwicki, J. E., Cuervo, A. M., Zuiderweg, E. R. P. & Santambrogio, L., Aug 26 2016, In : Journal of Biological Chemistry. 291, 35, p. 18096-18106 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
2015

Annexin A2 promotes phagophore assembly by enhancing Atg16L+ vesicle biogenesis and homotypic fusion

Morozova, K., Sidhar, S., Zolla, V., Clement, C. C., Scharf, B., Verzani, Z., Diaz, A., Larocca, J. N., Hajjar, K. A., Cuervo, A. M. & Santambrogio, L., Jan 2015, In : Nature communications. 6, 5856.

Research output: Contribution to journalArticle

19 Scopus citations

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

Kaushik, S. & Cuervo, A. M., Jun 1 2015, In : Nature Cell Biology. 17, 6, p. 759-770 12 p.

Research output: Contribution to journalArticle

205 Scopus citations

HTT/Huntingtin in selective autophagy and Huntington disease: A foe or a friend within?

Rui, Y. N., Xu, Z., Patel, B., Cuervo, A. M. & Zhang, S., Jan 1 2015, In : Autophagy. 11, 5, p. 858-860 3 p.

Research output: Contribution to journalArticle

15 Scopus citations

Huntingtin functions as a scaffold for selective macroautophagy

Rui, Y. N., Xu, Z., Patel, B., Chen, Z., Chen, D., Tito, A., David, G., Sun, Y., Stimming, E. F., Bellen, H. J., Cuervo, A. M. & Zhang, S., Mar 2 2015, In : Nature Cell Biology. 17, 3, p. 262-275 14 p.

Research output: Contribution to journalArticle

175 Scopus citations

Hydrodynamic size-based separation and characterization of protein aggregates from total cell lysates

Tanase, M., Zolla, V., Clement, C. C., Borghi, F., Urbanska, A. M., Rodriguez-Navarro, J. A., Roda, B., Zattoni, A., Reschiglian, P., Cuervo, A. M. & Santambrogio, L., Jan 1 2015, In : Nature Protocols. 10, 1, p. 134-148 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging

Schneider, J. L., Villarroya, J., Diaz-Carretero, A., Patel, B., Urbanska, A. M., Thi, M. M., Villarroya, F., Santambrogio, L. & Cuervo, A. M., Apr 1 2015, In : Aging cell. 14, 2, p. 249-264 16 p.

Research output: Contribution to journalArticle

66 Scopus citations

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy

Arias, E., Koga, H., Diaz, A., Mocholi, E., Patel, B. & Cuervo, A. M., Jul 16 2015, In : Molecular Cell. 59, 2, p. 270-284 15 p.

Research output: Contribution to journalArticle

105 Scopus citations

Methods to study chaperone-mediated autophagy

Patel, B. & Cuervo, A. M., Mar 15 2015, In : Methods. 75, p. 133-140 8 p.

Research output: Contribution to journalArticle

31 Scopus citations