Molecular Pharmacology

Projects

Projects per year 1976 1985 1989 1996 1998 2004 2007 2009 2010 2011 2012 2014 2016 2017 2018 2019 2020 2023

• 15 Active
• 164 Finished

Projects per year

Search results

• Finished

  Deciphering the enigmatic role of IGF-1 signaling in cognitive decline and Alzheimer's disease

  Huffman, D. M.

  9/15/20 → 8/31/21

  Project: Research project

  • Insulin-Like Growth Factor I 100%
  • Cognitive Dysfunction 52%
  • Alzheimer Disease 38%
  • Amyloidosis 31%
  • Insulin 28%

• Deciphering the enigmatic role of IGF-1 signaling in cognitive decline and Alzheimer's disease

  Huffman, D. M. & Gandy, S. E.

  National Institute on Aging

  9/15/20 → 8/31/21

  Project: Research project

  • Insulin-Like Growth Factor I 100%
  • Cognitive Dysfunction 66%
  • Alzheimer Disease 57%
  • Amyloidosis 32%
  • Insulin 30%

• BTBD9, a novel regulator of manganese-induced neurotoxicity

  Chen, P.

  9/10/20 → 8/31/21

  Project: Research project

  • Manganese 100%
  • Somatomedins 41%
  • Restless Legs Syndrome 40%
  • Caenorhabditis elegans 14%
  • Neurobiology 10%

• BTBD9, a novel regulator of manganese-induced neurotoxicity

  Chen, P.

  National Institute of Environmental Health Sciences

  9/10/20 → 8/31/22

  Project: Research project

  • Manganese 100%
  • Somatomedins 43%
  • Restless Legs Syndrome 41%
  • Caenorhabditis elegans 15%
  • Neurobiology 10%

• A systems approach for identifying geroprotector synergy in Alzheimer's disease

  Huffman, D. M.

  5/1/20 → 4/30/22

  Project: Research project

  • Alzheimer Disease 100%
  • Systems Analysis 58%
  • Amyloidosis 28%
  • Gene Regulatory Networks 28%
  • Cognition 20%

• A systems approach for identifying geroprotector synergy in Alzheimer?s disease

  Huffman, D. M. & Tu, Z.

  National Institute on Aging

  5/1/20 → 4/30/22

  Project: Research project

  • Systems Analysis 100%
  • Alzheimer Disease 84%
  • Amyloidosis 26%
  • Gene Regulatory Networks 26%
  • Cognition 19%

• Determination of genome-wide splicing kinetics and their underlying regulation

  Gamble, M. J.

  4/1/20 → 3/31/22

  Project: Research project

  • Kinetics 100%
  • Introns 44%
  • Transcriptome 42%
  • Chromatin 40%
  • Histones 28%

• Determination of genome-wide splicing kinetics and their underlying regulation

  Gamble, M. J.

  National Institute of General Medical Sciences

  4/1/20 → 3/31/21

  Project: Research project

  • Kinetics 100%
  • Genome 66%
  • Introns 48%
  • Transcriptome 45%
  • Chromatin 44%

• Development of A Topical siRNA Therapy to Promote Burn Wound Healing via Depletion of the Novel Microtubule Regulatory, Fidgetin-Like-2

  DEY, A. & Sharp, D. J.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  9/11/19 → 8/31/21

  Project: Research project

  • Wound Healing 100%
  • Microtubules 96%
  • Small Interfering RNA 74%
  • Wounds and Injuries 57%
  • Re-Epithelialization 40%

• New Biosensor Tools for Diaphanous Related Formin MD1A and 2, Useful for Multiplex Imaging

  Hodgson, L.

  National Institute of General Medical Sciences

  7/1/19 → 3/31/21

  Project: Research project

  • Formins 100%
  • Biosensing Techniques 74%
  • rho GTP-Binding Proteins 68%
  • Energy Transfer 47%
  • Wiskott-Aldrich Syndrome Protein Family 30%

• Hypothalamic NF-kB and astrocytic programs in obesity

  Cai, D.

  6/1/19 → 3/31/22

  Project: Research project

  • Obesity 100%
  • Neurons 88%
  • Astrocytes 87%
  • Hypothalamus 66%
  • gamma-Aminobutyric Acid 45%

• Hypothalamic astrocyte-neuron relationship links overnutrition to hypertension

  Cai, D.

  3/15/19 → 1/31/22

  Project: Research project

  • Obesity 100%
  • Hypertension 85%
  • Astrocytes 50%
  • Neurons 40%
  • Blood-Brain Barrier 21%

• Hypothalamic astrocyte-neuron relationship links overnutrition to hypertension

  Cai, D. & Cai, D.

  National Heart, Lung, and Blood Institute

  3/15/19 → 1/31/23

  Project: Research project

  • Overnutrition 100%
  • Astrocytes 62%
  • Hypertension 50%
  • Neurons 41%
  • Obesity 32%

• Role of autophagy in manganese-induced neurotoxicity

  Zhang, Z.

  9/30/18 → 8/31/20

  Project: Research project

  • Manganese 100%
  • Autophagy 55%
  • Transcription Factors 11%
  • Lysosomes 10%
  • Neurodegenerative Diseases 9%

• Role of autophagy in manganese-induced neurotoxicity

  Zhang, Z. & Zhang, Z.

  National Institute of Environmental Health Sciences

  9/30/18 → 8/31/21

  Project: Research project

  • Manganese 100%
  • Autophagy 73%
  • Transcription Factors 12%
  • Lysosomes 11%
  • Neurodegenerative Diseases 9%

• Integration of RhoGTPase signaling during cell migration

  Hodgson, L., Cox, D. & Hodgson, L.

  National Institute of General Medical Sciences

  9/1/18 → 8/31/20

  Project: Research project

  • rho GTP-Binding Proteins 100%
  • Cell Movement 40%
  • Macrophage Colony-Stimulating Factor 38%
  • GTP Phosphohydrolases 27%
  • Macrophages 26%

• Fluorescent Nanodiamonds for Multiplexed Imaging and Diagnostics

  Backer, J. M.

  8/20/18 → 7/31/19

  Project: Research project

  • color 100%
  • diamonds 90%
  • color centers 61%
  • marking 58%
  • ligands 57%

• Developmental origin of serotonin dysfunction in cortical map disruption

  Sze, J. Y. & Sze, J. Y.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  5/1/18 → 4/30/21

  Project: Research project

  • Serotonin 100%
  • Neurons 42%
  • Prefrontal Cortex 34%
  • Hippocampus 30%
  • Brain 30%

• Optimizing resilience assays for biology of aging research in mice

  Huffman, D. M.

  9/15/17 → 5/31/22

  Project: Research project

  • Longevity 100%
  • Rodentia 55%
  • Starvation 48%
  • Aptitude 45%
  • Sex Characteristics 41%

• Optimizing resilience assays for biology of aging research in mice

  Huffman, D. M. & Huffman, D. M.

  National Institute on Aging

  9/15/17 → 5/31/18

  Project: Research project

  • Longevity 100%
  • Rodentia 55%
  • Starvation 48%
  • Aptitude 45%
  • Sex Characteristics 41%

• Development of a Topical siRNA Therapy to Promote Burn Wound Healing via Depletion of the Novel Microtubule Regulatory, Fidgetin-Like-2

  O'Rourke, B. P. & Sharp, D. J.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  9/1/17 → 2/28/18

  Project: Research project

  • Microtubules 100%
  • Wound Healing 96%
  • Small Interfering RNA 73%
  • Wounds and Injuries 71%
  • Cicatrix 25%

• Cell autonomous versus non-cell autonomous aging in intestinal decline and tumorigenesis

  Huffman, D. M. & Huffman, D. M.

  National Institute on Aging

  8/15/17 → 5/31/20

  Project: Research project

  • Parabiosis 100%
  • Carcinogenesis 89%
  • Stem Cells 59%
  • DNA Damage 53%
  • Cellular Senescence 44%

• Cell autonomous versus non-cell autonomous aging in intestinal decline and tumorigenesis

  Huffman, D. M.

  8/15/17 → 5/31/20

  Project: Research project

  • Parabiosis 100%
  • Carcinogenesis 77%
  • Stem Cells 59%
  • DNA Damage 53%
  • Cellular Senescence 44%

• The microtubule cytoskeleton as a novel target for cavernous nerve regeneration after prostatectomy

  Davies, K., Sharp, D. J. & Davies, K. P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  4/1/17 → 3/31/21

  Project: Research project

  • Nerve Regeneration 100%
  • Prostatectomy 91%
  • Cytoskeleton 79%
  • Microtubules 79%
  • Wounds and Injuries 45%

• Imaging VEGFR-1 in early metastatic lesions

  Backer, J. M.

  3/9/17 → 2/28/19

  Project: Research project

  • Vascular Endothelial Growth Factor Receptor-1 100%
  • Hematopoietic Stem Cells 54%
  • Neoplasm Metastasis 21%
  • Breast Neoplasms 17%
  • Click Chemistry 11%

• The Role of PI3Kbeta in Breast Cancer Metastasis

  Backer, J. M., Bresnick, A. R. & Backer, J. M.

  National Institute of General Medical Sciences

  8/1/16 → 7/31/21

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Breast Neoplasms 61%
  • Neoplasm Metastasis 59%
  • G-Protein-Coupled Receptors 43%
  • Podosomes 43%

• The Role of PI3Kbeta in Breast Cancer Metastasis

  Backer, J. M. & Bresnick, A. R.

  8/1/16 → 7/31/21

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Breast Neoplasms 46%
  • Neoplasm Metastasis 44%
  • G-Protein-Coupled Receptors 43%
  • Podosomes 43%

• TNF alpha and IL-1 beta as pro-geronic factors in intestinal aging

  Huffman, D. M.

  5/15/16 → 6/30/17

  Project: Research project

  • Interleukin-1 100%
  • Stem Cell Niche 70%
  • Parabiosis 59%
  • Intestines 33%
  • Genetic Models 30%

• TNF alpha and IL-1 beta as pro-geronic factors in intestinal aging

  Huffman, D. M.

  National Institute on Aging

  5/15/16 → 6/30/17

  Project: Research project

  • Interleukin-1 100%
  • Stem Cell Niche 70%
  • Parabiosis 59%
  • Interleukin-1beta 51%
  • Tumor Necrosis Factor-alpha 38%

• Roles of formins in breast cancer invasion

  Hodgson, L.

  National Cancer Institute

  4/6/16 → 3/31/18

  Project: Research project

  • biosensors 100%
  • breast neoplasms 84%
  • guanosinetriphosphatase 63%
  • microfilaments 59%
  • molecular motor proteins 46%

• Genetic Susceptibility to Manganese Neurotoxicity

  Aschner, M.

  National Institute of Environmental Health Sciences

  1/1/16 → 12/31/17

  Project: Research project

  • Manganese 100%
  • Genetic Predisposition to Disease 58%
  • Oxidative Stress 29%
  • Dopaminergic Neurons 14%
  • Parkinson Disease 11%

• Genetic Susceptibility to Manganese Neurotoxicity

  Aschner, M.

  1/1/16 → 12/31/17

  Project: Research project

  • Manganese 100%
  • Oxidative Stress 28%
  • Dopaminergic Neurons 13%
  • Parkinson Disease 10%
  • Winged-Helix Transcription Factors 10%

• Developmental origin of serotonin dysfunction in cortical map disruption

  Sze, J. Y.

  9/17/15 → 4/30/20

  Project: Research project

  • Serotonin 100%
  • Axons 36%
  • Neurons 29%
  • Mental Disorders 22%
  • Pyramidal Cells 14%

• Developmental origin of serotonin dysfunction in cortical map disruption

  Sze, J. Y.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  9/17/15 → 8/31/16

  Project: Research project

  • Serotonin 100%
  • Axons 37%
  • Neurons 30%
  • Mental Disorders 23%
  • Pyramidal Cells 15%

• Targeted drug delivery to tumor microenvironment

  Backer, J. M.

  3/20/15 → 4/19/16

  Project: Research project

  • tumors 100%
  • macrophages 70%
  • delivery 19%
  • drugs 14%
  • cancer 13%

• Clinical development of 18F PET tracer for imaging VEGF receptors

  Backer, J. M.

  9/16/14 → 5/31/18

  Project: Research project

  • Vascular Endothelial Growth Factor A 100%
  • Alkynes 63%
  • Angiogenesis Inhibitors 46%
  • Vascular Endothelial Growth Factor Receptor 46%
  • Lead 35%

• Regulation of the Class IA PI 3-kinase PIK3CB

  Backer, J. M., Bresnick, A. R. & Backer, J. M.

  National Institute of General Medical Sciences

  9/5/14 → 7/31/18

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • G-Protein-Coupled Receptors 38%
  • Neoplasms 19%
  • Growth 19%
  • Neoplasm Metastasis 14%

• Regulation of the Class IA PI 3-kinase PIK3CB

  Bresnick, A. R., Backer, J. M. & Bresnick, A. R.

  9/5/14 → 7/31/18

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • G-Protein-Coupled Receptors 36%
  • Neoplasms 18%
  • Growth 18%
  • Neoplasm Metastasis 13%

• Rac1 regulates protrusion and invasion of breast cancers in 3D

  Hodgson, L. & Hodgson, L.

  National Cancer Institute

  7/1/14 → 12/31/16

  Project: Research project

  • Podosomes 100%
  • Pseudopodia 67%
  • GTP Phosphohydrolases 51%
  • Breast Neoplasms 33%
  • Adenocarcinoma 17%

• Cellular Remodeling by Microtubule Severing

  Ross, J. L., Sharp, D. J. & Sharp, D. J.

  National Institute of General Medical Sciences

  7/1/14 → 12/31/18

  Project: Research project

  • Microtubules 100%
  • Cell Movement 75%
  • Centrosome 23%
  • Enzymes 15%
  • Human Development 9%

• PI 3-Kinase and Metastasis

  Backer, J. M.

  National Cancer Institute

  6/1/14 → 5/31/18

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Neoplasm Metastasis 64%
  • Macrophages 48%
  • G-Protein-Coupled Receptors 43%
  • Neoplasms 40%

• Hypothalamic HIF in Nutrient Sensing and Metabolic Control

  Cai, D. & Cai, D.

  National Institute of Diabetes and Digestive and Kidney Diseases

  4/1/14 → 3/31/20

  Project: Research project

  • hypoxia 100%
  • nutrients 60%
  • obesity 41%
  • energy balance 30%
  • physical activity 23%

• Hypothalamic HIF in Nutrient Sensing and Metabolic Control

  Cai, D. & Rose, S. A.

  4/1/14 → 3/31/20

  Project: Research project

  • hypoxia 100%
  • obesity 37%
  • energy balance 28%
  • nutrients 27%
  • physical activity 21%

• INA-14

  Aschner, M. & Rose, S. A.

  7/1/13 → 6/30/14

  Project: Research project

  • career development 100%
  • public speaking 92%
  • graduate students 83%
  • cooperative research 78%
  • neurodegenerative diseases 71%

• Hypothalamic IKK-beta in obesity-related hypertension

  Cai, D. & Cai, D.

  National Heart, Lung, and Blood Institute

  6/1/13 → 5/31/19

  Project: Research project

  • I-kappa B Kinase 100%
  • Pro-Opiomelanocortin 66%
  • Obesity 52%
  • Hypertension 44%
  • Neurons 39%

• Hypothalamic IKK-beta in obesity-related hypertension

  Cai, D. & Rose, S. A.

  6/1/13 → 5/31/19

  Project: Research project

  • Pro-Opiomelanocortin 100%
  • Obesity 84%
  • Neurons 58%
  • Glutamic Acid 45%
  • Hypertension 28%

• Peripheral and central IGF-1 action in energy balance and longevity modulation

  Huffman, D. M. & Huffman, D. M.

  National Institute on Aging

  5/1/13 → 4/30/16

  Project: Research project

  • Insulin-Like Growth Factor I 100%
  • Longevity 76%
  • Healthy Aging 33%
  • Hypothalamus 24%
  • Insulin 12%

• Genetic Modulation of MeHg-Induced Oxidative Stress in the Developing Brain

  Aschner, M., Rose, S. A. & Rose, S. A.

  8/3/12 → 9/30/17

  Project: Research project

  • Astrocytes 100%
  • Oxidative Stress 79%
  • Neuroprotection 76%
  • Genetic Predisposition to Disease 73%
  • Neurons 66%

• Genetic Modulation of MeHg-Induced Oxidative Stress in the Developing Brain

  Aschner, M. & Aschner, M.

  National Institute of Environmental Health Sciences

  8/3/12 → 3/31/15

  Project: Research project

  • Astrocytes 100%
  • Oxidative Stress 79%
  • Neurons 66%
  • Transcriptional Activation 65%
  • Up-Regulation 52%

• Modeling 5-HT-absorbing neurons in neuropathology of autism

  Sze, J. Y.

  7/20/12 → 4/30/15

  Project: Research project

  • Serotonin Plasma Membrane Transport Proteins 100%
  • Autistic Disorder 45%
  • Serotonin 32%
  • Neurons 18%
  • Amygdala 15%