Microbiology & Immunology

Projects

Projects per year 1987 2004 2008 2010 2011 2012 2015 2016 2017 2018 2019 2023

• 11 Active
• 223 Finished

Projects per year

Search results

• Finished

  Viral and host determinants of susceptibility of diverse hantaviruses

  Jangra, R. & Jangra, R. R. K.

  National Institute of Allergy and Infectious Diseases

  6/1/21 → 5/31/22

  Project: Research project

  • Hantavirus 100%
  • Hemorrhagic Fever with Renal Syndrome 19%
  • Hantavirus Infections 18%
  • Viruses 17%
  • Vaccines 10%

• Optimizing SARS-CoV-2 wastewater based surveillance in urban and university campus settings.

  Chandran, K.

  1/1/21 → 12/31/21

  Project: Research project

  • Waste Water 100%
  • SARS Virus 44%
  • Disease Outbreaks 11%
  • Coronavirus 10%
  • Microfluidics 10%

• TB Phage therapy: Optimizing delivery methods of mycobacteriophages to target intracellular Mycobacterium tuberculosis

  Jacobs Jr., W. R.

  12/7/20 → 11/30/21

  Project: Research project

  • Mycobacteriophages 100%
  • Mycobacterium tuberculosis 38%
  • Tuberculosis 32%
  • Phage Therapy 20%
  • Mycobacterium smegmatis 9%

• CCL2-CCR2b signaling in HIV-1 fitness and disease; Role of host genetic polymorphisms

  Prasad, V. R.

  7/1/20 → 5/31/22

  Project: Research project

  • HIV-1 100%
  • Endosomal Sorting Complexes Required for Transport 70%
  • Actins 48%
  • HIV 47%
  • Viruses 46%

• CCL2-CCR2b signaling in HIV-1 fitness and disease; Role of host genetic polymorphisms

  Prasad, V. R.

  National Institute of Allergy and Infectious Diseases

  7/1/20 → 5/31/21

  Project: Research project

  • HIV-1 100%
  • Genetic Polymorphisms 84%
  • Endosomal Sorting Complexes Required for Transport 75%
  • Actins 52%
  • HIV 51%

• Structure-based Vaccine Design for CCHFV

  Chandran, K.

  6/25/20 → 5/31/22

  Project: Research project

  • Crimean-Congo hemorrhagic fever virus 100%
  • National Institute of Allergy and Infectious Diseases (U.S.) 27%
  • Glycoproteins 23%
  • Ticks 21%
  • Vaccines 20%

• Structure-based Vaccine Design for CCHFV

  Chandran, K. & Chandran, K.

  National Institute of Allergy and Infectious Diseases

  6/25/20 → 5/31/21

  Project: Research project

  • Crimean-Congo hemorrhagic fever virus 100%
  • Vaccines 33%
  • National Institute of Allergy and Infectious Diseases (U.S.) 30%
  • Glycoproteins 25%
  • Ticks 22%

• Prometastatic Effects of Neoadjuvant Chemotherapy in Breast Cancer

  Karagiannis, G.

  National Cancer Institute

  9/16/19 → 8/31/21

  Project: Research project

  • Breast Neoplasms 100%
  • Drug Therapy 95%
  • Neoplasm Metastasis 70%
  • Neoplasms 64%
  • Macrophages 59%

• Regulation of SAMHD1 antiviral activity

  Diaz-Griffero, F.

  9/1/19 → 6/30/22

  Project: Research project

  • Antiviral Agents 100%
  • HIV-2 75%
  • Phosphorylation 60%
  • Dendritic Cells 52%
  • Reverse Transcription 51%

• Regulation of SAMHD1 antiviral activity

  Diaz-Griffero, F.

  National Institute of Allergy and Infectious Diseases

  9/1/19 → 6/30/22

  Project: Research project

  • HIV-1 100%
  • Nucleic Acids 88%
  • Antiviral Agents 80%
  • Innate Immunity 47%
  • Human Herpesvirus 2 46%

• Cytek Aurora Multiparameter Flow Cytometer

  Porcelli, S. A.

  8/1/19 → 7/31/20

  Project: Research project

  • Flow cytometry 100%
  • Fluorescence 38%
  • Dyes 37%
  • Semiconductor detectors 29%
  • Fluorophores 27%

• Cytek Aurora Multiparameter Flow Cytometer

  Porcelli, S. A.

  NIH Office of the Director

  8/1/19 → 7/31/20

  Project: Research project

  • Flow cytometry 100%
  • Fluorescence 38%
  • Dyes 37%
  • Semiconductor detectors 29%
  • Fluorophores 27%

• NIH Support for Conferences and Scientific Meetings

  Larsen, M. H.

  3/1/19 → 2/29/20

  Project: Research project

  • Mycobacterium 100%
  • mycobacterial diseases 86%
  • leprosy 41%
  • tuberculosis 34%
  • researchers 24%

• NIH Support for Conferences and Scientific Meetings

  Larsen, M. H.

  National Institute of Allergy and Infectious Diseases

  3/1/19 → 2/29/20

  Project: Research project

  • Mycobacterium 100%
  • mycobacterial diseases 86%
  • leprosy 41%
  • tuberculosis 34%
  • researchers 24%

• Prometheus: A Platform for Rapid Development of Human Antibody-based Therapeutics and Prophylactics against Emerging Viral Threats

  Chandran, K.

  2/14/19 → 1/31/22

  Project: Research project

  • Hantavirus 100%
  • Sin Nombre virus 73%
  • Crimean-Congo hemorrhagic fever virus 66%
  • Antibodies 31%
  • Nairovirus 25%

• Eradicating persistent M. tuberculosis by synthetic lethality of terminal respiratory oxidases

  Berney, M.

  11/13/18 → 10/31/21

  Project: Research project

  • Tuberculosis 100%
  • Mycobacterium tuberculosis 94%
  • 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl) imidazo(1,2-a)pyridine-3-carboxamide 79%
  • Cytochromes 69%
  • Electron Transport Complex IV 57%

• An immunotherapeutic strategy for the induction and stabilization of remission in type 1 diabetes

  DiLorenzo, T. P. & DiLorenzo, T. P.

  9/15/18 → 7/31/21

  Project: Research project

  • T-Lymphocytes 100%
  • Remission Induction 63%
  • Type 1 Diabetes Mellitus 57%
  • Antigens 51%
  • Immunological Synapses 48%

• An immunotherapeutic strategy for the induction and stabilization of remission in type 1 diabetes

  Almo, S. C., DiLorenzo, T. P. & DiLorenzo, T. P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/15/18 → 7/31/21

  Project: Research project

  • Remission Induction 100%
  • Type 1 Diabetes Mellitus 71%
  • T-Lymphocytes 61%
  • Antigens 31%
  • Immunological Synapses 29%

• The Study of Human Sulfuryl-Transfer Biology

  Leyh, T. S.

  9/8/18 → 8/31/21

  Project: Research project

  • Sulfotransferases 100%
  • monoamine-sulfating phenol sulfotransferase 29%
  • sapropterin 21%
  • Libraries 21%
  • Neurotransmitter Agents 20%

• Shortening Tuberculosis Chemotherapies using N-acetylcysteine

  Jacobs Jr., W. R.

  6/15/18 → 5/31/20

  Project: Research project

  • Acetylcysteine 100%
  • Tuberculosis 89%
  • Mycobacterium tuberculosis 86%
  • Pharmaceutical Preparations 44%
  • Multidrug-Resistant Tuberculosis 35%

• Rapid screening for modes-of-action of M. tuberculosis inhibitors by high-throughput metabolic fingerprinting

  Berney, M.

  6/11/18 → 5/31/21

  Project: Research project

  • Drug Discovery 100%
  • Mycobacterium tuberculosis 94%
  • Libraries 57%
  • Tuberculosis 53%
  • Genome 43%

• Rapid screening for modes-of-action of M. tuberculosis inhibitors by high-throughput metabolic fingerprinting

  Berney, M. & Berney, M.

  National Institute of Allergy and Infectious Diseases

  6/11/18 → 5/31/21

  Project: Research project

  • Drug Discovery 100%
  • Mycobacterium tuberculosis 94%
  • Tuberculosis 71%
  • Libraries 57%
  • Genome 43%

• Immunoregulation by indoleamine 2,3-dioxygenases in tuberculosis

  Porcelli, S. A., Chan, J. & Porcelli, S. A.

  5/1/18 → 4/30/22

  Project: Research project

  • Indoleamine-Pyrrole 2,3,-Dioxygenase 100%
  • Protein Isoforms 27%
  • Tuberculosis 24%
  • Immunosuppressive Agents 20%
  • Kynurenine 19%

• Structural, functional, and mechanistic anlaysis of autoreactive CD8 T cells

  DiLorenzo, T. P.

  2/8/18 → 1/31/22

  Project: Research project

  • T-Lymphocytes 100%
  • Alleles 59%
  • T-Cell Antigen Receptor 41%
  • Peptides 38%
  • Type 1 Diabetes Mellitus 36%

• Defining Novel Cellular Correlates of Protection Against Human Malaria by CyTOF

  Lauvau, G.

  2/6/18 → 1/31/21

  Project: Research project

  • Malaria 100%
  • Parasites 56%
  • Immunity 44%
  • T-Lymphocytes 33%
  • Antibody Formation 24%

• Defining Novel Cellular Correlates of Protection Against Human Malaria by CyTOF

  Lauvau, G. & Lauvau, G. S.

  National Institute of Allergy and Infectious Diseases

  2/6/18 → 1/31/21

  Project: Research project

  • Malaria 100%
  • Parasites 60%
  • Immunity 47%
  • T-Lymphocytes 36%
  • Antibody Formation 26%

• Targeting mycobacterial ribosomes as a new approach to tuberculosis vaccines

  Porcelli, S. A.

  1/1/18 → 12/31/20

  Project: Research project

  • Tuberculosis Vaccines 100%
  • Mycobacterium bovis 56%
  • Mycobacterium tuberculosis 50%
  • BCG Vaccine 47%
  • Antigens 44%

• Targeting mycobacterial ribosomes as a new approach to tuberculosis vaccines

  Porcelli, S. A. & Porcelli, S. A.

  National Institute of Allergy and Infectious Diseases

  1/1/18 → 12/31/20

  Project: Research project

  • Tuberculosis Vaccines 100%
  • Mycobacterium bovis 56%
  • Ribosomes 54%
  • Mycobacterium tuberculosis 50%
  • BCG Vaccine 47%

• Host-virus interactions in the control of filovirus entry

  Chandran, K. & Chandran, K.

  National Institute of Allergy and Infectious Diseases

  12/5/17 → 11/30/21

  Project: Research project

  • Filoviridae 100%
  • Host Microbial Interactions 48%
  • Membrane Fusion 33%
  • Filoviridae Infections 12%
  • Ebola Hemorrhagic Fever 9%

• Host-virus interactions in the control of filovirus entry

  Chandran, K.

  12/5/17 → 11/30/21

  Project: Research project

  • Filoviridae 100%
  • Membrane Fusion 32%
  • Host Microbial Interactions 16%
  • Filoviridae Infections 11%
  • Ebola Hemorrhagic Fever 9%

• Generation of a Complete Set of Precise Null Bar-Coded Deletion Mutants of Mycobacterium tuberculosis

  Jacobs Jr., W. R.

  9/14/17 → 8/31/21

  Project: Research project

  • Tuberculosis 100%
  • Multidrug-Resistant Tuberculosis 49%
  • Mycobacterium tuberculosis 39%
  • Extensively Drug-Resistant Tuberculosis 30%
  • Host-Pathogen Interactions 26%

• A Trojan Horse bispecific antibody strategy for broad filovirus therapeutics

  Lai, J. R. & Chandran, K.

  7/14/17 → 6/30/21

  Project: Research project

  • Filoviridae 100%
  • Monoclonal Antibodies 33%
  • Bispecific Antibodies 27%
  • Ebolavirus 26%
  • Sudan 17%

• A Trojan Horse bispecific antibody strategy for broad filovirus therapeutics

  Chandran, K., Lai, J. R. & Chandran, K.

  National Institute of Allergy and Infectious Diseases

  7/14/17 → 6/30/22

  Project: Research project

  • Filoviridae 100%
  • Bispecific Antibodies 59%
  • Monoclonal Antibodies 35%
  • Ebolavirus 27%
  • Sudan 18%

• Dissecting the receptor-mediated infection mechanisms of hantaviruses

  Chandran, K. & Chandran, K.

  National Institute of Allergy and Infectious Diseases

  7/1/17 → 6/30/22

  Project: Research project

  • Hantavirus 100%
  • Hantavirus Infections 79%
  • Endothelial Cells 23%
  • Disease Outbreaks 11%
  • Sin Nombre virus 11%

• Dissecting the receptor-mediated infection mechanisms of hantaviruses

  Chandran, K.

  7/1/17 → 6/30/22

  Project: Research project

  • Hantavirus 100%
  • Endothelial Cells 23%
  • Hantavirus Infections 19%
  • Disease Outbreaks 11%
  • Sin Nombre virus 11%

• Einstein-Rockefeller-CUNY Center for AIDS Research

  Bauman, L. J., Prasad, V. R., Goldstein, H., Berman, J. W., Anastos, K., Kalpana, G. V. & Arnsten, J. H.

  5/1/17 → 4/30/22

  Project: Research project

  • AIDS 100%
  • interdisciplinary research 55%
  • public health 24%
  • access to treatment 23%
  • research implementation 21%

• Ebolavirus and marburgvirus entry into cells

  Chandran, K.

  National Institute of Allergy and Infectious Diseases

  2/17/17 → 1/31/18

  Project: Research project

  • Filoviridae 100%
  • Marburgvirus 57%
  • Ebolavirus 53%
  • Membrane Fusion 35%
  • Filoviridae Infections 13%

• Allosteric Regulation of Human Cytosolic Sulfotransferases

  Leyh, T. S.

  1/1/17 → 12/31/20

  Project: Research project

  • Protein Isoforms 100%
  • Small Molecule Libraries 49%
  • sapropterin 49%
  • Dopamine 44%
  • Computer Simulation 33%

• Allosteric Regulation of Human Cytosolic Sulfotransferases

  Leyh, T. S. & Leyh, T. S.

  National Institute of General Medical Sciences

  1/1/17 → 12/31/19

  Project: Research project

  • Allosteric Regulation 100%
  • Sulfotransferases 94%
  • Protein Isoforms 76%
  • Small Molecule Libraries 38%
  • sapropterin 37%

• Modulation of Host Cell Environment by Mycobacterial PE/PPE Proteins

  Lee, S. C., Porcelli, S. A. & Lee, S. C.

  National Institute of Allergy and Infectious Diseases

  12/9/16 → 11/30/21

  Project: Research project

  • Autophagy 100%
  • Mycobacterium 56%
  • Proteins 33%
  • Phagosomes 33%
  • Virulence Factors 27%

• Modulation of Host Cell Environment by Mycobacterial PE/PPE Proteins

  Porcelli, S. A. & Porcelli, S. A.

  12/9/16 → 11/30/21

  Project: Research project

  • Autophagy 100%
  • Mycobacterium 56%
  • Phagosomes 33%
  • Virulence Factors 27%
  • Adaptive Immunity 26%

• Mechanisms of Plasmacytoid dendritic cell activation in vivo

  Fooksman, D. R. & Lauvau, G.

  National Institute of Allergy and Infectious Diseases

  12/8/16 → 11/30/18

  Project: Research project

  • Malaria 100%
  • Dendritic Cells 78%
  • Plasmodium yoelii 32%
  • Parasitic Diseases 23%
  • Drug Resistance 20%

• Mechanisms of Plasmacytoid dendritic cell activation in vivo

  Lauvau, G., Fooksman, D. R. & Lauvau, G.

  12/8/16 → 11/30/18

  Project: Research project

  • Malaria 100%
  • Dendritic Cells 39%
  • Plasmodium yoelii 32%
  • Parasitic Diseases 23%
  • Drug Resistance 20%

• Regulation of SAMHD1 antiviral activity

  Diaz-Griffero, F. & Diaz-Griffero, F.

  National Institute of General Medical Sciences

  9/20/16 → 8/31/19

  Project: Research project

  • Antiviral Agents 100%
  • HIV-2 92%
  • Phosphorylation 73%
  • Dendritic Cells 63%
  • Reverse Transcription 62%

• Regulation of SAMHD1 antiviral activity

  Diaz-Griffero, F.

  9/20/16 → 8/31/19

  Project: Research project

  • Antiviral Agents 100%
  • HIV-2 75%
  • Phosphorylation 60%
  • Dendritic Cells 52%
  • Reverse Transcription 51%

• Effect of drugs of abuse on CNS HIV-1 reservoirs and neuropathogenesis

  Kalpana, G. V., Prasad, V. R. & Prasad, V. R.

  9/1/16 → 7/31/22

  Project: Research project

  • Substance-Related Disorders 100%
  • HIV-1 98%
  • Cannabis 80%
  • HIV 78%
  • Cocaine 75%

• Effect of drugs of abuse on CNS HIV-1 reservoirs and neuropathogenesis

  Kalpana, G. V., Prasad, V. R. & Prasad, V. R.

  National Institute on Drug Abuse

  9/1/16 → 7/31/19

  Project: Research project

  • HIV-1 100%
  • Substance-Related Disorders 97%
  • Illicit Drugs 77%
  • HIV 47%
  • Astrocytes 24%

• Early cellular sensing of blood stage Plasmodium Parasites by Innate Immune Cells

  Lauvau, G.

  National Institute of Allergy and Infectious Diseases

  6/9/16 → 5/31/18

  Project: Research project

  • Interferon Type I 100%
  • Plasmodium 77%
  • Malaria 68%
  • Parasites 54%
  • Plasmodium yoelii 27%

• Early cellular sensing of blood stage Plasmodium Parasites by Innate Immune Cells

  Lauvau, G.

  6/9/16 → 5/31/18

  Project: Research project

  • Interferon Type I 100%
  • Malaria 68%
  • Plasmodium 33%
  • Plasmodium yoelii 27%
  • Interferons 25%

• Inhibition of methionine biosynthesis eliminates persistent M. tuberculosis.

  Berney, M.

  National Institute of Allergy and Infectious Diseases

  2/15/16 → 1/31/19

  Project: Research project

  • Methionine 100%
  • Tuberculosis 96%
  • Mycobacterium tuberculosis 83%
  • Pharmaceutical Preparations 53%
  • Extensively Drug-Resistant Tuberculosis 31%