Medicine

Projects

Projects per year 1975 2024

• 42 Not started
• 137 Active
• 755 Finished

Projects per year

Search results

• Research project

  Early Therapeutics Development with Phase II Emphasis

  Sparano, J. A. & Rose, S. A.

  Project: Research project

  • National Cancer Institute (U.S.) 100%
  • Contracts 80%
  • Neoplasms 27%
  • Clinical Trials 22%
  • Program Evaluation 19%

• Early Therapeutics Development with Phase II Emphasis

  Sparano, J. A.

  Project: Research project

  • National Cancer Institute (U.S.) 100%
  • Contracts 80%
  • Neoplasms 27%
  • Clinical Trials 22%
  • Program Evaluation 19%

• TAS:: 75 0850 ::TAS RECOVERY ACT - ACTNOW CLINICAL TRIAL 8376

  Sparano, J. A.

  Project: Research project

  • National Cancer Institute (U.S.) 100%
  • Clinical Trials 56%
  • Contracts 43%
  • TimeLine 32%
  • Neoplasms 23%

• MOLECULAR BIOLOGIC STUDIES ON THE CAUSE OF PARATHYROID NEOPLASIA

  Spiegel, A. M.

  Project: Research project

  • Parathyroid Glands 100%
  • Neoplasms 78%
  • Parathyroid Neoplasms 69%
  • Primary Hyperparathyroidism 32%
  • Germ-Line Mutation 30%

• STUDIES ON PSEUDOHYPOPARATHYROIDISM AND RELATED DISORDERS

  Spiegel, A. M.

  Project: Research project

  • Pseudohypoparathyroidism 100%
  • Parathyroid Hormone 43%
  • Hormones 22%
  • Adenylyl Cyclases 22%
  • Albright's hereditary osteodystrophy 18%

• HUMORAL HYPERCALCEMIA OF MALIGNANCY

  Spiegel, A. M.

  Project: Research project

  • Humoral Hypercalcemia Of Malignancy 100%
  • Hypercalcemia 68%
  • Leydig Cell Tumor 44%
  • Wells syndrome 42%
  • Inbred F344 Rats 34%

• Structure/Function Of Men1 Gene And Its Protein Product

  Spiegel, A. M., Wackym, P. A., Morell, R., Dibello, P. & Wackym, P. A.

  Project: Research project

  • neoplasms 100%
  • Drosophila 55%
  • mice 47%
  • genes 45%
  • proteins 27%

• MOLECULAR BIOLOGIC STUDIES ON THE CAUSE OF PARATHYROID NEOPLASIA

  Spiegel, A. M.

  Project: Research project

  • neoplasms 100%
  • parathyroid glands 42%
  • hyperparathyroidism 32%
  • oncogenes 24%
  • hyperplasia 21%

• STUDIES ON NEPHROGENIC DIABETES INSIDIPUS

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Nephrogenic Diabetes Insipidus 100%
  • Vasopressin Receptors 66%
  • Vasopressins 36%
  • Polydipsia 21%
  • Deamino Arginine Vasopressin 20%

• PSEUDOHYPOPARATHYROIDISM AND RELATED DISORDERS

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Pseudohypoparathyroidism 100%
  • Parathyroid Hormone 27%
  • Hormones 16%
  • Adenylyl Cyclases 12%
  • Albright's hereditary osteodystrophy 8%

• STUDIES ON A CALCIUM SENSING RECEPTOR

  Spiegel, A. M., Spiegel, A. M. & Spiegel, A. M.

  Project: Research project

  • Calcium-Sensing Receptors 100%
  • Familial Hypercalciuric Hypocalcemia 27%
  • GTP-Binding Protein alpha Subunits 21%
  • Complement System Proteins 19%
  • Metabotropic Glutamate Receptors 18%

• STUDIES ON A CALCIUM SENSING RECEPTOR

  Spiegel, A. M. & Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Calcium-Sensing Receptors 100%
  • Calcium 29%
  • GTP-Binding Proteins 22%
  • G-Protein-Coupled Receptors 17%
  • Familial Hypercalciuric Hypocalcemia 16%

• GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS

  Spiegel, A. M.

  Project: Research project

  • Guanine Nucleotides 100%
  • Carrier Proteins 68%
  • G-protein Beta gamma 17%
  • Signal Transduction 13%
  • Potassium Channels 10%

• Early Therapeutics Development with Phase II Emphasis

  Sparano, J. A.

  Project: Research project

  • National Cancer Institute (U.S.) 100%
  • Contracts 80%
  • Neoplasms 27%
  • Clinical Trials 22%
  • Program Evaluation 19%

• PSEUDOHYPOPARATHYROIDISM AND RELATED DISORDERS

  Spiegel, A. M.

  Project: Research project

  • Pseudohypoparathyroidism 100%
  • Adenylyl Cyclases 26%
  • Albright's hereditary osteodystrophy 21%
  • Hormones 18%
  • Hypoparathyroidism 16%

• STUDIES ON MCCUNE-ALBRIGHT SYNDROME

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • somatic mutation 100%
  • mutation 68%
  • skin lesions 61%
  • hyperthyroidism 59%
  • Cushing syndrome 49%

• GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS

  Spiegel, A. M.

  Project: Research project

  • GTP-Binding Proteins 100%
  • Guanine Nucleotides 49%
  • Carrier Proteins 34%
  • Transducin 29%
  • Rhodopsin 25%

• HUMORAL HYPERCALCEMIA OF MALIGNANCY

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Humoral Hypercalcemia Of Malignancy 100%
  • Hypercalcemia 57%
  • Inbred F344 Rats 28%
  • Prostaglandins 24%
  • Leydig Cell Tumor 22%

• STRUCTURE, SECRETION AND MECHANISM OF ACTION OF PARATHYROID HORMONE

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • parathyroid hormone 100%
  • mechanism of action 51%
  • secretion 37%
  • hormones 30%
  • developmental orthopedic disease 28%

• STRUCTURE AND FUNCTION OF THE MEN1 GENE AND ITS PROTEIN PRODUCT, MENIN

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Multiple Endocrine Neoplasia Type 1 100%
  • National Human Genome Research Institute (U.S.) 50%
  • tumor suppressor genes 33%
  • Genes 28%
  • Drosophila 26%

• STUDIES ON MCCUNE-ALBRIGHT SYNDROME

  Spiegel, A. M., Spiegel, A., Jamieson, J. & Spiegel, A.

  Project: Research project

  • somatic mutation 100%
  • skin lesions 61%
  • mutation 51%
  • mutants 43%
  • Cushing syndrome 42%

• GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS

  Spiegel, A. M.

  Project: Research project

  • GTP-Binding Proteins 100%
  • Guanine Nucleotides 41%
  • Carrier Proteins 28%
  • Transducin 24%
  • Rhodopsin 21%

• MOLECULAR BIOLOGIC STUDIES ON THE CAUSE OF PARATHYROID NEOPLASIA

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • neoplasms 100%
  • Parathyroid Glands 99%
  • Neoplasms 84%
  • Parathyroid Neoplasms 60%
  • parathyroid glands 53%

• MOLECULAR BIOLOGIC STUDIES ON THE CAUSE OF PARATHYROID NEOPLASIA

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • neoplasms 100%
  • parathyroid glands 32%
  • hyperparathyroidism 29%
  • adenoma 28%
  • tumor suppressor genes 26%

• Studies On A Calcium Sensing Receptor

  Spiegel, A. M., De Casper, A., Berndt, R. S. & Fine, J.

  Project: Research project

  • Calcium-Sensing Receptors 100%
  • Droseraceae 35%
  • Cysteine 26%
  • Disulfides 19%
  • Calcium 19%

• PSEUDOHYPOPARATHYROIDISM AND RELATED DISORDERS

  Spiegel, A. M.

  Project: Research project

  • Pseudohypoparathyroidism 100%
  • Parathyroid Hormone 26%
  • Hormones 13%
  • Adenylyl Cyclases 13%
  • Albright's hereditary osteodystrophy 10%

• STUDIES ON NEPHROGENIC DIABETES INSIDIPUS

  Spiegel, A. M.

  Project: Research project

  • Nephrogenic Diabetes Insipidus 100%
  • Vasopressin Receptors 69%
  • Vasopressins 41%
  • Polydipsia 18%
  • Deamino Arginine Vasopressin 17%

• PEDIATRIC HYDROXYUREA PHASE III CLINICAL TRIAL

  Minniti, C. P.

  Project: Research project

• GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Guanine Nucleotides 100%
  • Carrier Proteins 68%
  • G-protein Beta gamma 17%
  • Odorants 13%
  • Phosphatidylinositols 13%

• GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Guanine Nucleotides 100%
  • Carrier Proteins 68%
  • GTP-Binding Proteins 16%
  • Potassium Channels 13%
  • Mutation 13%

• Early Therapeutics Development with Phase II Emphasis

  Sparano, J. A.

  Project: Research project

  • National Cancer Institute (U.S.) 100%
  • Contracts 80%
  • Neoplasms 27%
  • Clinical Trials 22%
  • Program Evaluation 19%

• STUDIES ON MCCUNE-ALBRIGHT SYNDROME

  Spiegel, A. M. & Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • somatic mutation 100%
  • mutants 62%
  • skin lesions 59%
  • mutation 59%
  • Cushing syndrome 51%

• STRUCTURE AND FUNCTION OF THE MEN1 GENE AND ITS PROTEIN PRODUCT, MENIN

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • protein products 100%
  • tumor suppressor genes 60%
  • neoplasms 43%
  • genes 42%
  • somatic mutation 27%

• Structure/Function Of Men1 Gene And Its Protein Product

  Spiegel, A. M.

  National Institute on Deafness and Other Communication Disorders

  Project: Research project

  • neoplasms 100%
  • Drosophila 51%
  • genes 46%
  • mice 46%
  • proteins 38%

• Studies On A Calcium Sensing Receptor

  Spiegel, A. M.

  National Institute on Deafness and Other Communication Disorders

  Project: Research project

  • Calcium-Sensing Receptors 100%
  • Droseraceae 36%
  • Cysteine 27%
  • Familial Hypercalciuric Hypocalcemia 27%
  • Calcium 24%

• STRUCTURE, SECRETION AND MECHANISM OF ACTION OF PARATHYROID HORMONE

  Spiegel, A. M.

  Project: Research project

  • parathyroid hormone 100%
  • mechanism of action 34%
  • pathophysiology 32%
  • developmental orthopedic disease 22%
  • polypeptides 20%

• GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Guanine Nucleotides 100%
  • Carrier Proteins 68%
  • GTP-Binding Proteins 18%
  • Mutation 14%
  • Signal Transduction 14%

• STUDIES ON NEPHROGENIC DIABETES INSIPIDUS

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • diabetes insipidus 100%
  • Nephrogenic Diabetes Insipidus 91%
  • Vasopressin Receptors 52%
  • vasopressin 40%
  • receptors 32%

• STUDIES ON NEPHROGENIC DIABETES INSIPIDUS

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Nephrogenic Diabetes Insipidus 100%
  • Vasopressin Receptors 63%
  • Vasopressins 38%
  • Polydipsia 16%
  • Deamino Arginine Vasopressin 16%

• STUDIES ON MCCUNE-ALBRIGHT SYNDROME

  Spiegel, A. M.

  Project: Research project

  • somatic mutation 100%
  • skin lesions 92%
  • mutation 77%
  • mutants 65%
  • Cushing syndrome 63%

• GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Guanine Nucleotides 100%
  • Carrier Proteins 68%
  • GTP-Binding Proteins 37%
  • Complementary DNA 10%
  • Hormones 9%

• STUDIES ON PSEUDOHYPOPARATHYROIDISM AND RELATED DISORDERS

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Pseudohypoparathyroidism 100%
  • Parathyroid Hormone 24%
  • Adenylyl Cyclases 22%
  • Guanine Nucleotides 12%
  • Messenger RNA 12%