Research Output

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Review article
2020

Pathogenic Mechanisms of Somatic Mutation and Genome Mosaicism in Aging

Vijg, J. & Dong, X., Jul 9 2020, In : Cell. 182, 1, p. 12-23 12 p.

Research output: Contribution to journalReview article

Open Access
2019

MicroRNAs in Skeletal Muscle Aging: Current Issues and Perspectives

Jung, H. J., Lee, K. P., Kwon, K. S. & Suh, Y., Jun 18 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 7, p. 1008-1014 7 p.

Research output: Contribution to journalReview article

Open Access
9 Scopus citations
2018

All in the family: Proneural bHLH genes and neuronal diversity

Baker, N. E. & Brown, N. L., May 1 2018, In : Development (Cambridge). 145, 9, dev159426.

Research output: Contribution to journalReview article

11 Scopus citations

Cell fusion in the liver, revisited

Lizier, M., Castelli, A., Montagna, C., Lucchini, F., Vezzoni, P. & Faggioli, F., Feb 1 2018, In : World Journal of Hepatology. 10, 2, p. 213-221 9 p.

Research output: Contribution to journalReview article

3 Scopus citations

Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities

Hébert, J. M. & Vijg, J., May 2018, In : Trends in Neurosciences. 41, 5, p. 267-279 13 p.

Research output: Contribution to journalReview article

4 Scopus citations

Deciphering functional glycosaminoglycan motifs in development

Townley, R. A. & Bülow, H. E., Jun 1 2018, In : Current Opinion in Structural Biology. 50, p. 144-154 11 p.

Research output: Contribution to journalReview article

12 Scopus citations

Diverse roles for glycosaminoglycans in neural patterning

Saied-Santiago, K. & Bülow, H. E., Jan 2018, In : Developmental Dynamics. 247, 1, p. 54-74 21 p.

Research output: Contribution to journalReview article

12 Scopus citations

Mechanisms of cancer resistance in long-lived mammals

Seluanov, A., Gladyshev, V. N., Vijg, J. & Gorbunova, V., Jul 1 2018, In : Nature Reviews Cancer. 18, 7, p. 433-441 9 p.

Research output: Contribution to journalReview article

39 Scopus citations

Molecular genetics of 22q11.2 deletion syndrome

Morrow, B. E., McDonald-McGinn, D. M., Emanuel, B. S., Vermeesch, J. R. & Scambler, P. J., Oct 2018, In : American Journal of Medical Genetics, Part A. 176, 10, p. 2070-2081 12 p.

Research output: Contribution to journalReview article

13 Scopus citations

Neural circuits of sexual behavior in caenorhabditis elegans

Emmons, S. W., Jul 8 2018, In : Annual Review of Neuroscience. 41, p. 349-369 21 p.

Research output: Contribution to journalReview article

12 Scopus citations

Nuclear Genomic Instability and Aging

Niedernhofer, L. J., Gurkar, A. U., Wang, Y., Vijg, J., Hoeijmakers, J. H. J. & Robbins, P. D., Jun 20 2018, In : Annual Review of Biochemistry. 87, p. 295-322 28 p.

Research output: Contribution to journalReview article

20 Scopus citations

Somatic mutagenesis in mammals and its implications for human disease and aging

Zhang, L. & Vijg, J., Nov 23 2018, In : Annual Review of Genetics. 52, p. 397-419 23 p.

Research output: Contribution to journalReview article

23 Scopus citations
2017

A high-fidelity method for genomic sequencing of single somatic cells reveals a very high mutational burden

Vijg, J., Dong, X. & Zhang, L., Jul 1 2017, In : Experimental Biology and Medicine. 242, 13, p. 1318-1324 7 p.

Research output: Contribution to journalReview article

1 Scopus citations

A neurogenetic model for the study of schizophrenia spectrum disorders: The International 22q11.2 Deletion Syndrome Brain Behavior Consortium

Gur, R. E., Bassett, A. S., McDonald-Mcginn, D. M., Bearden, C. E., Chow, E., Emanuel, B. S., Owen, M., Swillen, A., Van Den Bree, M., Vermeesch, J., Vorstman, J. A. S., Warren, S., Lehner, T. & Morrow, B., Dec 1 2017, In : Molecular Psychiatry. 22, 12, p. 1664-1672 9 p.

Research output: Contribution to journalReview article

25 Scopus citations

Associating cellular epigenetic models with human phenotypes

Lappalainen, T. & Greally, J. M., Jul 1 2017, In : Nature Reviews Genetics. 18, 7, p. 441-451 11 p.

Research output: Contribution to journalReview article

94 Scopus citations

Challenges and progress in interpretation of non-coding genetic variants associated with human disease

Zhu, Y., Tazearslan, C. & Suh, Y., Jul 1 2017, In : Experimental Biology and Medicine. 242, 13, p. 1325-1334 10 p.

Research output: Contribution to journalReview article

8 Scopus citations

Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging

Olivieri, F., Capri, M., Bonafè, M., Morsiani, C., Jung, H. J., Spazzafumo, L., Viña, J. & Suh, Y., Jul 2017, In : Mechanisms of Ageing and Development. 165, p. 162-170 9 p.

Research output: Contribution to journalReview article

38 Scopus citations

Developmental Mechanisms of Aortic Valve Malformation and Disease

Wu, B., Wang, Y., Xiao, F., Butcher, J. T., Yutzey, K. E. & Zhou, B., Feb 10 2017, In : Annual Review of Physiology. 79, p. 21-41 21 p.

Research output: Contribution to journalReview article

22 Scopus citations

Genetic-epigenetic interactions in cis: A major focus in the post-GWAS era

Do, C., Shearer, A., Suzuki, M., Terry, M. B., Gelernter, J., Greally, J. M. & Tycko, B., Jun 19 2017, In : Genome biology. 18, 1, 120.

Research output: Contribution to journalReview article

47 Scopus citations

Genome and Epigenome Editing in Mechanistic Studies of Human Aging and Aging-Related Disease

Lau, C. H. & Suh, Y., Feb 1 2017, In : Gerontology. 63, 2, p. 103-117 15 p.

Research output: Contribution to journalReview article

7 Scopus citations

Genome instability: A conserved mechanism of ageing?

Vijg, J., Dong, X., Milholland, B. & Zhang, L., Jul 11 2017, In : Essays in Biochemistry. 61, 3, p. 305-315 11 p.

Research output: Contribution to journalReview article

13 Scopus citations

Genome instability and aging: Cause or effect?

Vijg, J. & Montagna, C., Oct 2017, In : Translational Medicine of Aging. 1, p. 5-11 7 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

In vivo genome editing in animals using AAV-CRISPR system: Applications to translational research of human disease

Lau, C. H. & Suh, Y., 2017, In : F1000Research. 6, 2153.

Research output: Contribution to journalReview article

32 Scopus citations

Population epigenetics

Greally, J. M., Feb 1 2017, In : Current Opinion in Systems Biology. 1, p. 84-89 6 p.

Research output: Contribution to journalReview article

5 Scopus citations
2016

Do DNA Double-Strand Breaks Drive Aging?

White, R. R. & Vijg, J., Sep 1 2016, In : Molecular Cell. 63, 5, p. 729-738 10 p.

Research output: Contribution to journalReview article

64 Scopus citations

Epigenome-wide Association Studies and the Interpretation of Disease -Omics

Birney, E., Smith, G. D. & Greally, J. M., Jun 2016, In : PLoS genetics. 12, 6, e1006105.

Research output: Contribution to journalReview article

95 Scopus citations

Technological advances in precision medicine and drug development

Maggi, E., Patterson, N. E. & Montagna, C., May 3 2016, In : Expert Review of Precision Medicine and Drug Development. 1, 3, p. 331-343 13 p.

Research output: Contribution to journalReview article

4 Scopus citations

The Essence of Aging

Vijg, J. & Kennedy, B. K., Jun 15 2016, In : Gerontology. 62, 4, p. 381-385 5 p.

Research output: Contribution to journalReview article

12 Scopus citations
2015

A global reference for human genetic variation

Auton, A., Abecasis, G. R., Altshuler, D. M., Durbin, R. M., Bentley, D. R., Chakravarti, A., Clark, A. G., Donnelly, P., Eichler, E. E., Flicek, P., Gabriel, S. B., Gibbs, R. A., Green, E. D., Hurles, M. E., Knoppers, B. M., Korbel, J. O., Lander, E. S., Lee, C., Lehrach, H., Mardis, E. R. & 457 others, Marth, G. T., McVean, G. A., Nickerson, D. A., Schmidt, J. P., Sherry, S. T., Wang, J., Wilson, R. K., Boerwinkle, E., Doddapaneni, H., Han, Y., Korchina, V., Kovar, C., Lee, S., Muzny, D., Reid, J. G., Zhu, Y., Chang, Y., Feng, Q., Fang, X., Guo, X., Jian, M., Jiang, H., Jin, X., Lan, T., Li, G., Li, J., Li, Y., Liu, S., Liu, X., Lu, Y., Ma, X., Tang, M., Wang, B., Wang, G., Wu, H., Wu, R., Xu, X., Yin, Y., Zhang, D., Zhang, W., Zhao, J., Zhao, M., Zheng, X., Gupta, N., Gharani, N., Toji, L. H., Gerry, N. P., Resch, A. M., Barker, J., Clarke, L., Gil, L., Hunt, S. E., Kelman, G., Kulesha, E., Leinonen, R., McLaren, W. M., Radhakrishnan, R., Roa, A., Smirnov, D., Smith, R. E., Streeter, I., Thormann, A., Toneva, I., Vaughan, B., Zheng-Bradley, X., Grocock, R., Humphray, S., James, T., Kingsbury, Z., Sudbrak, R., Albrecht, M. W., Amstislavskiy, V. S., Borodina, T. A., Lienhard, M., Mertes, F., Sultan, M., Timmermann, B., Yaspo, M. L., Fulton, L., Ananiev, V., Belaia, Z., Beloslyudtsev, D., Bouk, N., Chen, C., Church, D., Cohen, R., Cook, C., Garner, J., Hefferon, T., Kimelman, M., Liu, C., Lopez, J., Meric, P., O'Sullivan, C., Ostapchuk, Y., Phan, L., Ponomarov, S., Schneider, V., Shekhtman, E., Sirotkin, K., Slotta, D., Zhang, H., Balasubramaniam, S., Burton, J., Danecek, P., Keane, T. M., Kolb-Kokocinski, A., McCarthy, S., Stalker, J., Quail, M., Davies, C. J., Gollub, J., Webster, T., Wong, B., Zhan, Y., Campbell, C. L., Kong, Y., Marcketta, A., Yu, F., Antunes, L., Bainbridge, M., Sabo, A., Huang, Z., Coin, L. J. M., Fang, L., Li, Q., Li, Z., Lin, H., Liu, B., Luo, R., Shao, H., Xie, Y., Ye, C., Yu, C., Zhang, F., Zheng, H., Zhu, H., Alkan, C., Dal, E., Kahveci, F., Garrison, E. P., Kural, D., Lee, W. P., Leong, W. F., Stromberg, M., Ward, A. N., Wu, J., Zhang, M., Daly, M. J., DePristo, M. A., Handsaker, R. E., Banks, E., Bhatia, G., Del Angel, G., Genovese, G., Li, H., Kashin, S., McCarroll, S. A., Nemesh, J. C., Poplin, R. E., Yoon, S. C., Lihm, J., Makarov, V., Gottipati, S., Keinan, A., Rodriguez-Flores, J. L., Rausch, T., Fritz, M. H., Stütz, A. M., Beal, K., Datta, A., Herrero, J., Ritchie, G. R. S., Zerbino, D., Sabeti, P. C., Shlyakhter, I., Schaffner, S. F., Vitti, J., Cooper, D. N., Ball, E. V., Stenson, P. D., Barnes, B., Bauer, M., Cheetham, R. K., Cox, A., Eberle, M., Kahn, S., Murray, L., Peden, J., Shaw, R., Kenny, E. E., Batzer, M. A., Konkel, M. K., Walker, J. A., MacArthur, D. G., Lek, M., Herwig, R., Ding, L., Koboldt, D. C., Larson, D., Ye, K., Gravel, S., Swaroop, A., Chew, E., Lappalainen, T., Erlich, Y., Gymrek, M., Willems, T. F., Simpson, J. T., Shriver, M. D., Rosenfeld, J. A., Bustamante, C. D., Montgomery, S. B., De La Vega, F. M., Byrnes, J. K., Carroll, A. W., DeGorter, M. K., Lacroute, P., Maples, B. K., Martin, A. R., Moreno-Estrada, A., Shringarpure, S. S., Zakharia, F., Halperin, E., Baran, Y., Cerveira, E., Hwang, J., Malhotra, A., Plewczynski, D., Radew, K., Romanovitch, M., Zhang, C., Hyland, F. C. L., Craig, D. W., Christoforides, A., Homer, N., Izatt, T., Kurdoglu, A. A., Sinari, S. A., Squire, K., Xiao, C., Sebat, J., Antaki, D., Gujral, M., Noor, A., Ye, K., Burchard, E. G., Hernandez, R. D., Gignoux, C. R., Haussler, D., Katzman, S. J., Kent, W. J., Howie, B., Ruiz-Linares, A., Dermitzakis, E. T., Devine, S. E., Kang, H. M., Kidd, J. M., Blackwell, T., Caron, S., Chen, W., Emery, S., Fritsche, L., Fuchsberger, C., Jun, G., Li, B., Lyons, R., Scheller, C., Sidore, C., Song, S., Sliwerska, E., Taliun, D., Tan, A., Welch, R., Wing, M. K., Zhan, X., Awadalla, P., Hodgkinson, A., Li, Y., Shi, X., Quitadamo, A., Lunter, G., Marchini, J. L., Myers, S., Churchhouse, C., Delaneau, O., Gupta-Hinch, A., Kretzschmar, W., Iqbal, Z., Mathieson, I., Menelaou, A., Rimmer, A., Xifara, D. K., Oleksyk, T. K., Fu, Y., Liu, X., Xiong, M., Jorde, L., Witherspoon, D., Xing, J., Browning, B. L., Browning, S. R., Hormozdiari, F., Sudmant, P. H., Khurana, E., Tyler-Smith, C., Albers, C. A., Ayub, Q., Chen, Y., Colonna, V., Jostins, L., Walter, K., Xue, Y., Gerstein, M. B., Abyzov, A., Balasubramanian, S., Chen, J., Clarke, D., Fu, Y., Harmanci, A. O., Jin, M., Lee, D., Liu, J., Mu, X. J., Zhang, J., Zhang, Y., Hartl, C., Shakir, K., Degenhardt, J., Meiers, S., Raeder, B., Casale, F. P., Stegle, O., Lameijer, E. W., Hall, I., Bafna, V., Michaelson, J., Gardner, E. J., Mills, R. E., Dayama, G., Chen, K., Fan, X., Chong, Z., Chen, T., Chaisson, M. J., Huddleston, J., Malig, M., Nelson, B. J., Parrish, N. F., Blackburne, B., Lindsay, S. J., Ning, Z., Zhang, Y., Lam, H., Sisu, C., Challis, D., Evani, U. S., Lu, J., Nagaswamy, U., Yu, J., Li, W., Habegger, L., Yu, H., Cunningham, F., Dunham, I., Lage, K., Jespersen, J. B., Horn, H., Kim, D., Desalle, R., Narechania, A., Sayres, M. A. W., Mendez, F. L., Poznik, G. D., Underhill, P. A., Mittelman, D., Banerjee, R., Cerezo, M., Fitzgerald, T. W., Louzada, S., Massaia, A., Yang, F., Kalra, D., Hale, W., Dan, X., Barnes, K. C., Beiswanger, C., Cai, H., Cao, H., Henn, B., Jones, D., Kaye, J. S., Kent, A., Kerasidou, A., Mathias, R., Ossorio, P. N., Parker, M., Rotimi, C. N., Royal, C. D., Sandoval, K., Su, Y., Tian, Z., Tishkoff, S., Via, M., Wang, Y., Yang, H., Yang, L., Zhu, J., Bodmer, W., Bedoya, G., Cai, Z., Gao, Y., Chu, J., Peltonen, L., Garcia-Montero, A., Orfao, A., Dutil, J., Martinez-Cruzado, J. C., Mathias, R. A., Hennis, A., Watson, H., McKenzie, C., Qadri, F., LaRocque, R., Deng, X., Asogun, D., Folarin, O., Happi, C., Omoniwa, O., Stremlau, M., Tariyal, R., Jallow, M., Joof, F. S., Corrah, T., Rockett, K., Kwiatkowski, D., Kooner, J., Hien, T. T., Dunstan, S. J., ThuyHang, N., Fonnie, R., Garry, R., Kanneh, L., Moses, L., Schieffelin, J., Grant, D. S., Gallo, C., Poletti, G., Saleheen, D., Rasheed, A., Brooks, L. D., Felsenfeld, A. L., McEwen, J. E., Vaydylevich, Y., Duncanson, A., Dunn, M. & Schloss, J. A., Sep 30 2015, In : Nature. 526, 7571, p. 68-74 7 p.

Research output: Contribution to journalReview article

4385 Scopus citations

E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease

Wang, L. H. & Baker, N. E., Nov 9 2015, In : Developmental cell. 35, 3, p. 269-280 12 p.

Research output: Contribution to journalReview article

49 Scopus citations

Genome-wide assays that identify and quantify modified cytosines in human disease studies

Ulahannan, N. & Greally, J. M., Jan 22 2015, In : Epigenetics and Chromatin. 8, 1, 5.

Research output: Contribution to journalReview article

23 Scopus citations

High-throughput sequencing in mutation detection: A new generation of genotoxicity tests?

Maslov, A. Y., Quispe-Tintaya, W., Gorbacheva, T., White, R. R. & Vijg, J., Jun 1 2015, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 776, p. 136-143 8 p.

Research output: Contribution to journalReview article

24 Scopus citations

How might epigenetic dysregulation in early embryonic life contribute to autism spectrum disorder?

Berko, E. R. & Greally, J. M., Feb 1 2015, In : Epigenomics. 7, 1, p. 1-4 4 p.

Research output: Contribution to journalReview article

4 Scopus citations

Interventions to slow aging in humans: Are we ready?

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown-Borg, H. M., Caruso, C., Curiel, T. J., De Cabo, R., Franceschi, C., Gems, D., Ingram, D. K., Johnson, T. E., Kennedy, B. K., Kenyon, C., Klein, S., Kopchick, J. J., Lepperdinger, G., Madeo, F., Mirisola, M. G., Mitchell, J. R. & 10 others, Passarino, G., Rudolph, K. L., Sedivy, J. M., Shadel, G. S., Sinclair, D. A., Spindler, S. R., Suh, Y., Vijg, J., Vinciguerra, M. & Fontana, L., Aug 1 2015, In : Aging cell. 14, 4, p. 497-510 14 p.

Research output: Contribution to journalReview article

252 Scopus citations

New insights and updated guidelines for epigenome-wide association studies

Chadwick, L. H., Sawa, A., Yang, I. V., Baccarelli, A., Breakefield, X. O., Deng, H. W., Dolinoy, D. C., Fallin, M. D., Holland, N. T., Houseman, E. A., Lomvardas, S., Rao, M., Satterlee, J. S., Tyson, F. L., Vijayanand, P. & Greally, J. M., Jan 1 2015, In : Neuroepigenetics. 1, p. 14-19 6 p.

Research output: Contribution to journalReview article

17 Scopus citations

Regulation of IGF -1 signaling by microRNAs

Jung, H. J. & Suh, Y., 2015, In : Frontiers in Genetics. 5, JAN, 472.

Research output: Contribution to journalReview article

50 Scopus citations
22 Scopus citations
2014

Chromosomal rearrangements in cancer: Detection and potential causal mechanisms

Hasty, P. & Montagna, C., Jan 1 2014, In : Molecular and Cellular Oncology. 1, 1, e29904.

Research output: Contribution to journalReview article

21 Scopus citations

Circulating miRNAs in Ageing and Ageing-Related Diseases

Jung, H. J. & Suh, Y., Sep 20 2014, In : Journal of Genetics and Genomics. 41, 9, p. 465-472 8 p.

Research output: Contribution to journalReview article

57 Scopus citations

Comparative genetics of longevity and cancer: Insights from long-lived rodents

Gorbunova, V., Seluanov, A., Zhang, Z., Gladyshev, V. N. & Vijg, J., Aug 2014, In : Nature Reviews Genetics. 15, 8, p. 531-540 10 p.

Research output: Contribution to journalReview article

102 Scopus citations

Genome maintenance and human longevity

Cho, M. & Suh, Y., Jun 2014, In : Current Opinion in Genetics and Development. 26, p. 105-115 11 p.

Research output: Contribution to journalReview article

6 Scopus citations

Innovating aging: Promises and pitfalls on the road to life extension

Vijg, J. & De Grey, A. D. N. J., Jun 2014, In : Gerontology. 60, 4, p. 373-380 8 p.

Research output: Contribution to journalReview article

17 Scopus citations

Nanotoxicity overview: Nano-threat to susceptible populations

Li, Y., Zhang, Y. & Yan, B., Feb 28 2014, In : International Journal of Molecular Sciences. 15, 3, p. 3671-3697 27 p.

Research output: Contribution to journalReview article

Open Access
55 Scopus citations

Perturbation of physiological systems by nanoparticles

Zhang, Y., Bai, Y., Jia, J., Gao, N., Li, Y., Zhang, R., Jiang, G. & Yan, B., May 21 2014, In : Chemical Society Reviews. 43, 10, p. 3762-3809 48 p.

Research output: Contribution to journalReview article

68 Scopus citations

Somatic mutations, genome mosaicism, cancer and aging

Vijg, J., Jun 1 2014, In : Current Opinion in Genetics and Development. 26, p. 141-149 9 p.

Research output: Contribution to journalReview article

61 Scopus citations

The development of sexual dimorphism: Studies of the Caenorhabditis elegans male

Emmons, S. W., Jan 1 2014, In : Wiley Interdisciplinary Reviews: Developmental Biology. 3, 4, p. 239-262 24 p.

Research output: Contribution to journalReview article

13 Scopus citations
2013

Genome instability and aging

Vijg, J. & Suh, Y., Feb 10 2013, In : Annual review of physiology. 75, p. 645-668 24 p.

Research output: Contribution to journalReview article

166 Scopus citations

Nfatc1 directs the endocardial progenitor cells to make heart valve primordium

Wu, B., Baldwin, H. S. & Zhou, B., Nov 1 2013, In : Trends in Cardiovascular Medicine. 23, 8, p. 294-300 7 p.

Research output: Contribution to journalReview article

16 Scopus citations

Perinatal nutrition programs the hypothalamic melanocortin system in offspring

Wattez, J. S., Delahaye, F., Lukaszewski, M. A., Risold, P. Y., Eberlé, D., Vieau, D. & Breton, C., Dec 1 2013, In : Hormone and Metabolic Research. 45, 13, p. 980-990 11 p.

Research output: Contribution to journalReview article

18 Scopus citations

Recommendations for the design and analysis of epigenome-wide association studies

Michels, K. B., Binder, A. M., Dedeurwaerder, S., Epstein, C. B., Greally, J. M., Gut, I., Houseman, E. A., Izzi, B., Kelsey, K. T., Meissner, A., Milosavljevic, A., Siegmund, K. D., Bock, C. & Irizarry, R. A., Oct 1 2013, In : Nature Methods. 10, 10, p. 949-955 7 p.

Research output: Contribution to journalReview article

211 Scopus citations