Research Output

Filter
Article
2013

FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress

Jeong, Y. T., Rossi, M., Cermak, L., Saraf, A., Florens, L., Washburn, M. P., Sung, P., Schildkraut, C. & Pagano, M., Jan 2013, In : Journal of Cell Biology. 200, 2, p. 141-149 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer

Bhattacharyya, S., Yu, Y., Suzuki, M., Campbell, N., Mazdo, J., Vasanthakumar, A., Bhagat, T. D., Nischal, S., Christopeit, M., Parekh, S., Steidl, U., Godley, L., Maitra, A., Greally, J. M. & Verma, A., Sep 1 2013, In : Nucleic Acids Research. 41, 16, p. e157

Research output: Contribution to journalArticle

48 Scopus citations

Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry

Ooi, Y. S., Stiles, K. M., Liu, C. Y., Taylor, G. M. & Kielian, M., Jan 1 2013, In : PLoS pathogens. 9, 12, p. 1-10 10 p., e1003835.

Research output: Contribution to journalArticle

47 Scopus citations

H1 linker histone promotes epigenetic silencing by regulating both DNA methylation and histone H3 methylation

Yang, S. M., Kim, B. J., Toro, L. N. & Skoultchi, A. I., Jan 29 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 5, p. 1708-1713 6 p.

Research output: Contribution to journalArticle

66 Scopus citations

HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function

Zhao, R., Chinai, J. M., Buhl, S., Scandiuzzi, L., Ray, A., Jeon, H., Ohaegbulam, K. C., Ghosh, K., Zhao, A., Scharff, M. D. & Zang, X., Jun 11 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 24, p. 9879-9884 6 p.

Research output: Contribution to journalArticle

67 Scopus citations

High resolution methylome analysis reveals widespread functional hypomethylation during adult human erythropoiesis

Yu, Y., Mo, Y., Ebenezer, D., Bhattacharyya, S., Liu, H., Sundaravel, S., Giricz, O., Wontakal, S., Cartier, J., Caces, B., Artz, A., Nischal, S., Bhagat, T., Bathon, K., Maqbool, S., Gligich, O., Suzuki, M., Steidl, U., Godley, L., Skoultchi, A. & 3 others, Greally, J., Wickrema, A. & Verma, A., Mar 29 2013, In : Journal of Biological Chemistry. 288, 13, p. 8805-8814 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells

Ding, B. B., Bi, E., Chen, H., Yu, J. J. & Ye, B. H., Feb 15 2013, In : Journal of Immunology. 190, 4, p. 1827-1836 10 p.

Research output: Contribution to journalArticle

72 Scopus citations

Imaging of the alphavirus capsid protein during virus replication

Zheng, Y. & Kielian, M., 2013, In : Journal of virology. 87, 17, p. 9579-9589 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes

Schaetzlein, S., Chahwan, R., Avdievich, E., Roa, S., Wei, K., Eoff, R. L., Sellers, R. S., Clark, A. B., Kunkelf, T. A., Scharff, M. D. & Edelmann, W., Jul 2 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 27, p. E2470-E2479

Research output: Contribution to journalArticle

38 Scopus citations

Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching

Bothmer, A., Rommel, P. C., Gazumyan, A., Polato, F., Reczek, C. R., Muellenbeck, M. F., Schaetzlein, S., Edelmann, W., Chen, P. L., Brosh, R. M., Casellas, R., Ludwig, T., Baer, R., Nussenzweig, A., Nussenzweig, M. C. & Robbiani, D. F., Jan 2013, In : Journal of Experimental Medicine. 210, 1, p. 115-123 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Membrane localization of Junín virus glycoproteins requires cholesterol and cholesterol rich membranes

Cordo, S. M., Valko, A., Martinez, G. M. & Candurra, N. A., Jan 18 2013, In : Biochemical and Biophysical Research Communications. 430, 3, p. 912-917 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Methylome profiling reveals distinct alterations in phenotypic and mutational subgroups of myeloproliferative neoplasms

Nischal, S., Bhattacharyya, S., Christopeit, M., Yu, Y., Zhou, L., Bhagat, T. D., Sohal, D., Will, B., Mo, Y., Suzuki, M., Pardanani, A., Michael McDevitt, M., Maciejewski, J. P., Melnick, A. M., Greally, J. M., Steidl, U., Moliterno, A. & Verma, A., Feb 1 2013, In : Cancer Research. 73, 3, p. 1076-1085 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Mice Transgenic for CD4-Specific Human CD4, CCR5 and Cyclin T1 Expression: A New Model for Investigating HIV-1 Transmission and Treatment Efficacy

Seay, K., Qi, X., Zheng, J. H., Zhang, C., Chen, K., Dutta, M., Deneroff, K., Ochsenbauer, C., Kappes, J. C., Littman, D. R. & Goldstein, H., May 15 2013, In : PloS one. 8, 5, e63537.

Research output: Contribution to journalArticle

24 Scopus citations

MiR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling

Bhagat, T. D., Zhou, L., Sokol, L., Kessel, R., Caceres, G., Gundabolu, K., Tamari, R., Gordon, S., Mantzaris, I., Jodlowski, T., Yu, Y., Jing, X., Polineni, R., Bhatia, K., Pellagatti, A., Boultwood, J., Kambhampati, S., Steidl, U., Stein, C., Ju, W. & 5 others, Liu, G., Kenny, P., List, A., Bitzer, M. & Verma, A., Apr 11 2013, In : Blood. 121, 15, p. 2875-2881 7 p.

Research output: Contribution to journalArticle

76 Scopus citations

Myeloma is characterized by stage-specific alterations in DNA methylation that occur early during myelomagenesis

Heuck, C. J., Mehta, J., Bhagat, T., Gundabolu, K., Yu, Y., Khan, S., Chrysofakis, G., Schinke, C., Tariman, J., Vickrey, E., Pulliam, N., Nischal, S., Zhou, L., Bhattacharyya, S., Meagher, R., Hu, C., Maqbool, S., Suzuki, M., Parekh, S., Reu, F. & 4 others, Steidl, U., Greally, J., Verma, A. & Singhal, S. B., Mar 15 2013, In : Journal of Immunology. 190, 6, p. 2966-2975 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes

Fröbel, J., Cadeddu, R. P., Hartwig, S., Bruns, I., Wilk, C. M., Kun̈dgen, A., Fischer, J. C., Schroeder, T., Steidl, U. G., Germing, U., Lehr, S., Haas, R. & Czibere, A., May 2013, In : Molecular and Cellular Proteomics. 12, 5, p. 1272-1280 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells

Tam, W. L., Lu, H., Buikhuisen, J., Soh, B. S., Lim, E., Reinhardt, F., Wu, Z. J., Krall, J. A., Bierie, B., Guo, W., Chen, X., Liu, X. S., Brown, M., Lim, B. & Weinberg, R. A., Sep 9 2013, In : Cancer Cell. 24, 3, p. 347-364 18 p.

Research output: Contribution to journalArticle

180 Scopus citations

Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment

Will, B., Vogler, T. O., Bartholdy, B., Garrett-Bakelman, F., Mayer, J., Barreyro, L., Pandolfi, A., Todorova, T. I., Okoye-Okafor, U. C., Stanley, R. F., Bhagat, T. D., Verma, A., Figueroa, M. E., Melnick, A., Roth, M. & Steidl, U., May 1 2013, In : Nature Immunology. 14, 5, p. 437-445 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Splicing proofreading at 5′ splice sites by ATPase Prp28p

Yang, F., Wang, X. Y., Zhang, Z. M., Pu, J., Fan, Y. J., Zhou, J., Query, C. C. & Xu, Y. Z., Apr 1 2013, In : Nucleic acids research. 41, 8, p. 4660-4670 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Stability and prognostic value of Slug, Sox9 and Sox10 expression in breast cancers treated with neoadjuvant chemotherapy

Riemenschnitter, C., Teleki, I., Tischler, V., Guo, W. & Varga, Z., Jan 1 2013, In : SpringerPlus. 2, 1, 695.

Research output: Contribution to journalArticle

14 Scopus citations

Staphylococcal enterotoxin B-specific monoclonal antibody 20B1 successfully treats diverse staphylococcus aureus infections

Varshney, A. K., Wang, X., Scharff, M. D., Maclntyre, J., Zollner, R. S., Kovalenko, O. V., Martinez, L. R., Byrne, F. R. & Fries, B. C., Dec 15 2013, In : Journal of Infectious Diseases. 208, 12, p. 2058-2066 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
36 Scopus citations

The oncogenic MicroRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation

Song, S. J., Ito, K., Ala, U., Kats, L., Webster, K., Sun, S. M., Jongen-Lavrencic, M., Manova-Todorova, K., Teruya-Feldstein, J., Avigan, D. E., Delwel, R. & Pandolfi, P. P., Jul 3 2013, In : Cell Stem Cell. 13, 1, p. 87-101 15 p.

Research output: Contribution to journalArticle

199 Scopus citations

The role of E3 in pH protection during alphavirus assembly and exit

Uchime, O., Fields, W. & Kielian, M., Sep 5 2013, In : Journal of virology. 87, 18, p. 10255-10262 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus

Martinez, M. G., Bialecki, M. A., Belouzard, S., Cordo, S. M., Candurra, N. A. & Whittaker, G. R., Nov 22 2013, In : Biochemical and Biophysical Research Communications. 441, 3, p. 612-617 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
2012

A complex of methylthioadenosine/ S -adenosylhomocysteine nucleosidase, transition state analogue, and nucleophilic water identified by mass spectrometry

Wang, S., Lim, J., Thomas, K., Yan, F., Angeletti, R. H. & Schramm, V. L., Jan 25 2012, In : Journal of the American Chemical Society. 134, 3, p. 1468-1470 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation

Wontakal, S. N., Guo, X., Smith, C., MacCarthy, T., Bresnick, E. H., Bergman, A., Snyder, M. P., Weissman, S. M., Zheng, D. & Skoultchi, A. I., Mar 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 10, p. 3832-3837 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

Akt inhibitors MK-2206 and nelfinavir overcome mTOR inhibitor resistance in diffuse large B-cell lymphoma

Petrich, A. M., Leshchenko, V., Kuo, P. Y., Xia, B., Thirukonda, V. K., Ulahannan, N., Gordon, S., Fazzari, M. J., Ye, B. H., Sparano, J. A. & Parekh, S., May 1 2012, In : Clinical Cancer Research. 18, 9, p. 2534-2544 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

A metabolic prosurvival role for PML in breast cancer

Carracedo, A., Weiss, D., Leliaert, A. K., Bhasin, M., De Boer, V. C. J., Laurent, G., Adams, A. C., Sundvall, M., Song, S. J., Ito, K., Finley, L. S., Egia, A., Libermann, T., Gerhart-Hines, Z., Puigserver, P., Haigis, M. C., Maratos-Flier, E., Richardson, A. L., Schafer, Z. T. & Pandolfi, P. P., Sep 4 2012, In : Journal of Clinical Investigation. 122, 9, p. 3088-3100 13 p.

Research output: Contribution to journalArticle

143 Scopus citations

An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses

Helguera, G., Jemielity, S., Abraham, J., Cordo, S. M., Martinez, M. G., Rodríguez, J. A., Bregni, C., Wang, J. J., Farzan, M., Penichet, M. L., Candurra, N. A. & Choe, H., Apr 1 2012, In : Journal of virology. 86, 7, p. 4024-4028 5 p.

Research output: Contribution to journalArticle

29 Scopus citations

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2

Kaufmann, K. B., Gründer, A., Hadlich, T., Wehrle, J., Gothwal, M., Bogeska, R., Seeger, T. S., Kayser, S., Pham, K. B., Jutzi, J. S., Ganzenmüller, L., Steinemann, D., Schlegelberger, B., Wagner, J. M., Jung, M., Will, B., Steidl, U., Aumann, K., Werner, M., Günther, T. & 3 others, Schüle, R., Rambaldi, A. & Pahl, H. L., Jan 2012, In : Journal of Experimental Medicine. 209, 1, p. 35-50 16 p.

Research output: Contribution to journalArticle

51 Scopus citations

A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for helicobacter pylori

Wang, S., Haapalainen, A. M., Yan, F., Du, Q., Tyler, P. C., Evans, G. B., Rinaldo-Matthis, A., Brown, R. L., Norris, G. E., Almo, S. C. & Schramm, V. L., Sep 4 2012, In : Biochemistry. 51, 35, p. 6892-6894 3 p.

Research output: Contribution to journalArticle

32 Scopus citations

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

Ito, K., Carracedo, A., Weiss, D., Arai, F., Ala, U., Avigan, D. E., Schafer, Z. T., Evans, R. M., Suda, T., Lee, C. H. & Pandolfi, P. P., Sep 1 2012, In : Nature Medicine. 18, 9, p. 1350-1358 9 p.

Research output: Contribution to journalArticle

336 Scopus citations

A transgenic mouse model expressing exclusively human hemoglobin E: Indications of a mild oxidative stress

Chen, Q., Fabry, M. E., Rybicki, A. C., Suzuka, S. M., Balazs, T. C., Etzion, Z., de Jong, K., Akoto, E. K., Canterino, J. E., Kaul, D. K., Kuypers, F. A., Lefer, D., Bouhassira, E. E. & Hirsch, R. E., Feb 15 2012, In : Blood Cells, Molecules, and Diseases. 48, 2, p. 91-101 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

A U1-U2 snRNP interaction network during intron definition

Shao, W., Kim, H. S., Cao, Y., Xu, Y. Z. & Query, C. C., Jan 2012, In : Molecular and cellular biology. 32, 2, p. 470-478 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Autophagy driven by a master regulator of hematopoiesis

Kang, Y. A., Sanalkumar, R., O'geen, H., Linnemann, A. K., Chang, C. J., Bouhassira, E. E., Farnham, P. J., Keles, S. & Bresnick, E. H., Jan 2012, In : Molecular and cellular biology. 32, 1, p. 226-239 14 p.

Research output: Contribution to journalArticle

78 Scopus citations

CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis

Chung, E. Y., Psathas, J. N., Yu, D., Li, Y., Weiss, M. J. & Thomas-Tikhonenko, A., Jun 1 2012, In : Journal of Clinical Investigation. 122, 6, p. 2257-2266 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome

Query, C. C. & Konarska, M. M., May 1 2012, In : RNA. 18, 5, p. 1001-1013 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Chemokine 25 - Induced signaling suppresses colon cancer invasion and metastasis

Chen, H. J., Edwards, R., Tucci, S., Bu, P., Milsom, J., Lee, S., Edelmann, W., Güm̈us, Z. H., Shen, X. & Lipkin, S., Sep 4 2012, In : Journal of Clinical Investigation. 122, 9, p. 3184-3196 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres

Remeseiro, S., Cuadrado, A., Carretero, M., Mart́nez, P., Drosopoulos, W. C., Cañamero, M., Schildkraut, C. L., Blasco, M. A. & Losada, A., May 2 2012, In : EMBO Journal. 31, 9, p. 2076-2089 14 p.

Research output: Contribution to journalArticle

98 Scopus citations

Complex N-glycans are essential, but core 1 and 2 mucin O-glycans, O-fucose glycans, and NOTCH1 are dispensable, for mammalian spermatogenesis

Batista, F., Lu, L., Williams, S. A. & Stanley, P., Jun 1 2012, In : Biology of Reproduction. 86, 6, 179.

Research output: Contribution to journalArticle

31 Scopus citations

Effect of caloric intake on western-style diet-induced intestinal tumors in a mouse model for hereditary colon cancer

Itano, O., Fan, K., Yang, K., Suzuki, K., Quimby, F., Dong, Z., Jin, B., Edelmann, W. & Lipkin, M., Apr 1 2012, In : Nutrition and Cancer. 64, 3, p. 401-408 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation

Roth, M., Will, B., Simkin, G., Narayanagari, S., Barreyro, L., Bartholdy, B., Tamari, R., Mitsiades, C. S., Verma, A. & Steidl, U., Jul 12 2012, In : Blood. 120, 2, p. 386-394 9 p.

Research output: Contribution to journalArticle

85 Scopus citations

Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling

Wu, B., Zhang, Z., Lui, W., Chen, X., Wang, Y., Chamberlain, A. A., Moreno-Rodriguez, R. A., Markwald, R. R., O'Rourke, B. P., Sharp, D. J., Zheng, D., Lenz, J., Baldwin, H. S., Chang, C. P. & Zhou, B., Nov 21 2012, In : Cell. 151, 5, p. 1083-1096 14 p.

Research output: Contribution to journalArticle

195 Scopus citations

Galactose differentially modulates lunatic and manic fringe effects on Delta1-induced NOTCH signaling

Hou, X., Tashima, Y. & Stanley, P., Jan 2 2012, In : Journal of Biological Chemistry. 287, 1, p. 474-483 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Germline deletion of Igh 3′ regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus

Volpi, S. A., Verma-Gaur, J., Hassan, R., Ju, Z., Roa, S., Chatterjee, S., Werling, U., Hou, H., Will, B., Steidl, U., Scharff, M., Edelman, W., Feeney, A. J. & Birshtein, B. K., Mar 15 2012, In : Journal of Immunology. 188, 6, p. 2556-2566 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

H2.0-like Homeobox Regulates Early Hematopoiesis and Promotes Acute Myeloid Leukemia

Kawahara, M., Pandolfi, A., Bartholdy, B., Barreyro, L., Will, B., Roth, M., Okoye-Okafor, U. C., Todorova, T. I., Figueroa, M. E., Melnick, A., Mitsiades, C. S. & Steidl, U., Aug 14 2012, In : Cancer Cell. 22, 2, p. 194-208 15 p.

Research output: Contribution to journalArticle

32 Scopus citations

Hierarchical Modularity and the Evolution of Genetic Interactomes across Species

Ryan, C. J., Roguev, A., Patrick, K., Xu, J., Jahari, H., Tong, Z., Beltrao, P., Shales, M., Qu, H., Collins, S. R., Kliegman, J. I., Jiang, L., Kuo, D., Tosti, E., Kim, H. S., Edelmann, W., Keogh, M. C., Greene, D., Tang, C., Cunningham, P. & 7 others, Shokat, K. M., Cagney, G., Svensson, J. P., Guthrie, C., Espenshade, P. J., Ideker, T. & Krogan, N. J., Jun 8 2012, In : Molecular Cell. 46, 5, p. 691-704 14 p.

Research output: Contribution to journalArticle

126 Scopus citations

Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway

Nishiyama, M., Skoultchi, A. I. & Nakayama, K. I., Jan 1 2012, In : Molecular and cellular biology. 32, 2, p. 501-512 12 p.

Research output: Contribution to journalArticle

66 Scopus citations

Histone modifications and lamin A regulate chromatin protein dynamics in early embryonic stem cell differentiation

Melcer, S., Hezroni, H., Rand, E., Nissim-Rafinia, M., Skoultchi, A., Stewart, C. L., Bustin, M. & Meshorer, E., Jul 6 2012, In : Nature communications. 3, 910.

Research output: Contribution to journalArticle

93 Scopus citations