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2014

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function

Papa, A., Wan, L., Bonora, M., Salmena, L., Song, M. S., Hobbs, R. M., Lunardi, A., Webster, K., Ng, C., Newton, R. H., Knoblauch, N., Guarnerio, J., Ito, K., Turka, L. A., Beck, A. H., Pinton, P., Bronson, R. T., Wei, W. & Pandolfi, P. P., Apr 24 2014, In : Cell. 157, 3, p. 595-610 16 p.

Research output: Contribution to journalArticle

143 Scopus citations

Catalytic site cooperativity in dimeric methylthioadenosine nucleosidase

Wang, S., Thomas, K. & Schramm, V. L., Mar 11 2014, In : Biochemistry. 53, 9, p. 1527-1535 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cis-acting DNA sequence at a replication origin promotes repeat expansion to fragile X full mutation

Gerhardt, J., Zaninovic, N., Zhan, Q., Madireddy, A., Nolin, S. L., Ersalesi, N., Yan, Z., Rosenwaks, Z. & Schildkraut, C. L., 2014, In : Journal of Cell Biology. 206, 5, p. 599-607 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Concise review: Breast cancer stem cells: Regulatory networks, stem cell niches, and disease relevance

Guo, W., Ruth, L. & Gottesman, D. S., 2014, In : Stem Cells Translational Medicine. 3, 8, p. 942-948 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Detection and measurement of staphylococcal enterotoxin-like K (SEl-K) secretion by Staphylococcus aureus clinical isolates

Aguilar, J. L., Varshney, A. K., Wang, X., Stanford, L., Scharff, M. & Fries, B. C., Jul 2014, In : Journal of Clinical Microbiology. 52, 7, p. 2536-2543 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

Santos, M. A., Faryabi, R. B., Ergen, A. V., Day, A. M., Malhowski, A., Canela, A., Onozawa, M., Lee, J. E., Callen, E., Gutierrez-Martinez, P., Chen, H. T., Wong, N., Finkel, N., Deshpande, A., Sharrow, S., Rossi, D. J., Ito, K., Ge, K., Aplan, P. D., Armstrong, S. A. & 1 others, Nussenzweig, A., Oct 2 2014, In : Nature. 514, 7520, p. 107-111 5 p.

Research output: Contribution to journalArticle

103 Scopus citations

DNA damage response, redox status and hematopoiesis

Weiss, C. N. & Ito, K., Jan 1 2014, In : Blood Cells, Molecules, and Diseases. 52, 1, p. 12-18 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
17 Scopus citations

Drosophila TAP/p32 is a core histone chaperone that cooperates with NAP-1, NLP, And nucleophosmin in sperm chromatin remodeling during fertilization

Emelyanov, A. V., Rabbani, J., Mehta, M., Vershilova, E., Keogh, M. C. & Fyodorov, D. V., Sep 15 2014, In : Genes and Development. 28, 18, p. 2027-2040 14 p.

Research output: Contribution to journalArticle

12 Scopus citations
8 Scopus citations

Endogenous U2•U5•U6 snRNA complexes in S. pombe are intron lariat spliceosomes

Chen, W., Shulha, H. P., Ashar-Patel, A., Yan, J., Green, K. M., Query, C. C., Rhind, N., Weng, Z. & Moore, M. J., Mar 1 2014, In : RNA. 20, 3, p. 308-320 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Erythropoiesis from human embryonic stem cells through erythropoietin- independent AKT signaling

Kim, W. S., Zhu, Y., Deng, Q., Chin, C. J., He, C. B., Grieco, A. J., Dravid, G. G., Parekh, C., Hollis, R. P., Lane, T. F., Bouhassira, E. E., Kohn, D. B. & Crooks, G. M., Jun 2014, In : STEM CELLS. 32, 6, p. 1503-1514 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells

Tosti, E., Katakowski, J. A., Schaetzlein, S., Kim, H. S., Ryan, C. J., Shales, M., Roguev, A., Krogan, N. J., Palliser, D., Keogh, M. C. & Edelmann, W., Sep 17 2014, In : Genome Medicine. 6, 9, 68.

Research output: Contribution to journalArticle

9 Scopus citations

Evolving views of breast cancer stem cells and their differentiation states

Condiotti, R., Guo, W. & Ben-Porath, I., Jan 1 2014, In : Critical Reviews in Oncogenesis. 19, 5, p. 337-348 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Gut microbial metabolism drives transformation of msh2-deficient colon epithelial cells

Belcheva, A., Irrazabal, T., Robertson, S. J., Streutker, C., Maughan, H., Rubino, S., Moriyama, E. H., Copeland, J. K., Kumar, S., Green, B., Geddes, K., Pezo, R. C., Navarre, W. W., Milosevic, M., Wilson, B. C., Girardin, S. E., Wolever, T. M. S., Edelmann, W., Guttman, D. S., Philpott, D. J. & 1 others, Martin, A., Jul 17 2014, In : Cell. 158, 2, p. 288-299 12 p.

Research output: Contribution to journalArticle

195 Scopus citations

Histone H1.3 suppresses H19 noncoding RNA expression and cell growth of ovarian cancer cells

Medrzycki, M., Zhang, Y., Zhang, W., Cao, K., Pan, C., Lailler, N., McDonald, J. F., Bouhassira, E. E. & Fan, Y., Nov 15 2014, In : Cancer Research. 74, 22, p. 6463-6473 11 p.

Research output: Contribution to journalArticle

59 Scopus citations

HSC commitment-associated epigenetic signature is prognostic in acute myeloid leukemia

Bartholdy, B., Christopeit, M., Will, B., Mo, Y., Barreyro, L., Yu, Y., Bhagat, T. D., Okoye-Okafor, U. C., Todorova, T. I., Greally, J. M., Levine, R. L., Melnick, A., Verma, A. & Steidl, U., Mar 3 2014, In : Journal of Clinical Investigation. 124, 3, p. 1158-1167 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Human liver cell trafficking mutants: Characterization and whole exome sequencing

Yuan, F., Snapp, E. L., Novikoff, P. M., Suadicani, S. O., Spray, D. C., Potvin, B., Wolkoff, A. W. & Stanley, P., Jan 23 2014, In : PloS one. 9, 1, e87043.

Research output: Contribution to journalArticle

Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function

Kim, H. S., Mukhopadhyay, R., Rothbart, S. B., Silva, A. C., Vanoosthuyse, V., Radovani, E., Kislinger, T., Roguev, A., Ryan, C. J., Xu, J., Jahari, H., Hardwick, K. G., Greenblatt, J. F., Krogan, N. J., Fillingham, J. S., Strahl, B. D., Bouhassira, E. E., Edelmann, W. & Keogh, M. C., 2014, In : Cell Reports. 6, 5, p. 892-905 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Imaging the alphavirus exit pathway

Martinez, M. G., Snapp, E. L., Perumal, G. S., Macaluso, F. P. & Kielian, M., Jun 2014, In : Journal of virology. 88, 12, p. 6922-6933 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Isotype switching increases efficacy of antibody protection against staphylococcal enterotoxin B-induced lethal shock and Staphylococcus aureus sepsis in mice

Varshney, A. K., Wang, X., Aguilar, J. L., Scharff, M. D. & Fries, B. C., Jun 10 2014, In : mBio. 5, 3, e01007-14.

Research output: Contribution to journalArticle

25 Scopus citations

Mechanisms of virus membrane fusion proteins

Kielian, M., Sep 29 2014, In : Annual Review of Virology. 1, 1, p. 171-189 19 p.

Research output: Contribution to journalArticle

54 Scopus citations

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution

Vierstra, J., Rynes, E., Sandstrom, R., Zhang, M., Canfield, T., Scott Hansen, R., Stehling-Sun, S., Sabo, P. J., Byron, R., Humbert, R., Thurman, R. E., Johnson, A. K., Vong, S., Lee, K., Bates, D., Neri, F., Diegel, M., Giste, E., Haugen, E., Dunn, D. & 17 others, Wilken, M. S., Josefowicz, S., Samstein, R., Chang, K. H., Eichler, E. E., De Bruijn, M., Reh, T. A., Skoultchi, A., Rudensky, A., Orkin, S. H., Papayannopoulou, T., Treuting, P. M., Selleri, L., Kaul, R., Groudine, M., Bender, M. A. & Stamatoyannopoulos, J. A., Nov 21 2014, In : Science. 346, 6212, p. 1007-1012 6 p.

Research output: Contribution to journalArticle

117 Scopus citations

Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery

Murphy, A. K., Fitzgerald, M., Ro, T., Kim, J. H., Rabinowitsch, A. I., Chowdhury, D., Schildkraut, C. L. & Borowiec, J. A., 2014, In : Journal of Cell Biology. 206, 4, p. 493-507 15 p.

Research output: Contribution to journalArticle

55 Scopus citations

Pivotal role of augmented αb-crystallin in tumor development induced by deficient TSC1/2 complex

Wang, F., Chen, X., Li, C., Sun, Q., Chen, Y., Wang, Y., Peng, H., Liu, Z., Chen, R., Liu, K., Yan, H., Ye, B. H., Kwiatkowski, D. J. & Zhang, H., Aug 21 2014, In : Oncogene. 33, 34, p. 4352-4358 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome

Colak, D., Zaninovic, N., Cohen, M. S., Rosenwaks, Z., Yang, W. Y., Gerhardt, J., Disney, M. D. & Jaffrey, S. R., Jan 1 2014, In : Science. 343, 6174, p. 1002-1005 4 p.

Research output: Contribution to journalArticle

157 Scopus citations

Rapid assays for lectin toxicity and binding changes that reflect altered glycosylation in mammalian cells

Stanley, P. & Sundaram, S., Jan 1 2014, In : Current protocols in chemical biology. 6, 2, p. 117-133 17 p.

Research output: Contribution to journalArticle

4 Scopus citations

Reduction in Golgi apparatus dimension in the absence of a residential protein, N-acetylglucosaminyltransferase v

Dong, Z., Zuber, C., Pierce, M., Stanley, P. & Roth, J., Feb 1 2014, In : Histochemistry and Cell Biology. 141, 2, p. 153-164 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Rubella Virus: First Calcium-Requiring Viral Fusion Protein

Dubé, M., Rey, F. A. & Kielian, M., Dec 1 2014, In : PLoS pathogens. 10, 12

Research output: Contribution to journalArticle

22 Scopus citations

Selective activity of the histone deacetylase inhibitor AR-42 against leukemia stem cells: A novel potential strategy in acute myelogenous leukemia

Guzman, M. L., Yang, N., Sharma, K. K., Balys, M., Corbett, C. A., Jordan, C. T., Becker, M. W., Steidl, U., Abdel-Wahab, O., Levine, R. L., Marcucci, G., Roboz, G. J. & Hassane, D. C., Aug 2014, In : Molecular cancer therapeutics. 13, 8, p. 1979-1990 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Small RNAs derived from lncRNA RNase MRP have gene-silencing activity relevant to human cartilage-hair hypoplasia

Rogler, L. E., Kosmyna, B., Moskowitz, D., Bebawee, R., Rahimzadeh, J., Kutchko, K., Laederach, A., Notarangelo, L. D., Giliani, S., Bouhassira, E., Frenette, P., Roy-Chowdhury, J. & Rogler, C. E., Jan 2014, In : Human molecular genetics. 23, 2, p. 368-382 15 p.

Research output: Contribution to journalArticle

54 Scopus citations

Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation

Alvarez-Saavedra, M., De Repentigny, Y., Lagali, P. S., Raghu Ram, E. V. S., Yan, K., Hashem, E., Ivanochko, D., Huh, M. S., Yang, D., Mears, A. J., Todd, M. A. M., Corcoran, C. P., Bassett, E. A., Tokarew, N. J. A., Kokavec, J., Majumder, R., Ioshikhes, I., Wallace, V. A., Kothary, R., Meshorer, E. & 3 others, Stopka, T., Skoultchi, A. I. & Picketts, D. J., Jun 20 2014, In : Nature communications. 5, 4181.

Research output: Contribution to journalArticle

38 Scopus citations

The addition of rituximab to CHOP therapy alters the prognostic significance of CD44 expression

Wei, X., Xu, M., Wei, Y., Huang, F., Zhao, T., Li, X., Feng, R. & Ye, B. H., Apr 16 2014, In : Journal of Hematology and Oncology. 7, 1, 34.

Research output: Contribution to journalArticle

8 Scopus citations

The DNA Replication Program Is Altered at the FMR1 Locus in Fragile X Embryonic Stem Cells

Gerhardt, J., Tomishima, M. J., Zaninovic, N., Colak, D., Yan, Z., Zhan, Q., Rosenwaks, Z., Jaffrey, S. R. & Schildkraut, C. L., Jan 9 2014, In : Molecular Cell. 53, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

59 Scopus citations

The exosome complex establishes a barricade to erythroid maturation

McIver, S. C., Kang, Y. A., Devilbiss, A. W., O'Driscoll, C. A., Ouellette, J. N., Pope, N. J., Camprecios, G., Chang, C. J., Yang, D., Bouhassira, E. E., Ghaffari, S. & Bresnick, E. H., Oct 2 2014, In : Blood. 124, 14, p. 2285-2297 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair

Van Oers, J. M. M., Edwards, Y., Chahwan, R., Zhang, W., Smith, C., Pechuan, X., Schaetzlein, S., Jin, B., Wang, Y., Bergman, A., Scharff, M. D. & Edelmann, W., Jul 24 2014, In : Oncogene. 33, 30, p. 3939-3946 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
5 Scopus citations

The role of PML in hematopoietic and leukemic stem cell maintenance

Nakahara, F., Weiss, C. N. & Ito, K., Jul 2014, In : International journal of hematology. 100, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013

Accelerated Coronary Angiogenesis by Vegfr1-Knockout Endocardial Cells

Zhang, Z. & Zhou, B., Jul 24 2013, In : PloS one. 8, 7, e70570.

Research output: Contribution to journalArticle

15 Scopus citations

Activation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma treated with R-CHOP

Huang, X., Meng, B., Iqbal, J., Ding, B. B., Perry, A. M., Cao, W., Smith, L. M., Bi, C., Jiang, C., Greiner, T. C., Weisenburger, D. D., Rimsza, L., Rosenwald, A., Ott, G., Delabie, J., Campo, E., Braziel, R. M., Gascoyne, R. D., Cook, J. R., Tubbs, R. R. & 8 others, Jaffe, E. S., Armitage, J. O., Vose, J. M., Staudt, L. M., McKeithan, T. W., Chan, W. C., Ye, B. H. & Fu, K., Dec 30 2013, In : Journal of Clinical Oncology. 31, 36, p. 4520-4528 9 p.

Research output: Contribution to journalArticle

83 Scopus citations

A key interaction between the alphavirus envelope proteins responsible for initial dimer dissociation during fusion

Fields, W. & Kielian, M., Apr 1 2013, In : Journal of virology. 87, 7, p. 3774-3781 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

Vigant, F., Lee, J., Hollmann, A., Tanner, L. B., Akyol Ataman, Z., Yun, T., Shui, G., Aguilar, H. C., Zhang, D., Meriwether, D., Roman-Sosa, G., Robinson, L. R., Juelich, T. L., Buczkowski, H., Chou, S., Castanho, M. A. R. B., Wolf, M. C., Smith, J. K., Banyard, A., Kielian, M. & 7 others, Reddy, S., Wenk, M. R., Selke, M., Santos, N. C., Freiberg, A. N., Jung, M. E. & Lee, B., Apr 2013, In : PLoS pathogens. 9, 4, e1003297.

Research output: Contribution to journalArticle

45 Scopus citations

Arteriolar niches maintain haematopoietic stem cell quiescence

Kunisaki, Y., Bruns, I., Scheiermann, C., Ahmed, J., Pinho, S., Zhang, D., Mizoguchi, T., Wei, Q., Lucas, D., Ito, K., Mar, J. C., Bergman, A. & Frenette, P. S., Oct 10 2013, In : Nature. 502, 7473, p. 637-643 7 p.

Research output: Contribution to journalArticle

567 Scopus citations

Bisected, complex N-glycans and galectins in mouse mammary tumor progression and human breast cancer

Miwa, H. E., Koba, W. R., Fine, E. J., Giricz, O., Kenny, P. A. & Stanley, P., Dec 1 2013, In : Glycobiology. 23, 12, p. 1477-1490 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Caspase 9 is constitutively activated in mouse oocytes and plays a key role in oocyte elimination during meiotic prophase progression

Ene, A. C., Park, S., Edelmann, W. & Taketo, T., May 1 2013, In : Developmental Biology. 377, 1, p. 213-223 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Complete Genome Phasing of Family Quartet by Combination of Genetic, Physical and Population-Based Phasing Analysis

Lajugie, J., Mukhopadhyay, R., Schizas, M., Lailler, N., Fourel, N. & Bouhassira, E. E., May 31 2013, In : PloS one. 8, 5, e64571.

Research output: Contribution to journalArticle

7 Scopus citations

Cross-inhibition of chikungunya virus fusion and infection by alphavirus E1 domain III proteins

Martín, C. S. S., Nanda, S., Zheng, Y., Fields, W. & Kielian, M., Jul 2013, In : Journal of virology. 87, 13, p. 7680-7687 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina

Popova, E. Y., Grigoryev, S. A., Fan, Y., Skoultchi, A. I., Zhang, S. S. & Barnstable, C. J., Jun 14 2013, In : Journal of Biological Chemistry. 288, 24, p. 17895-17907 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9

Lu, X., Wontakal, S. N., Kavi, H., Kim, B. J., Guzzardo, P. M., Emelyanov, A. V., Xu, N., Hannon, G. J., Zavadil, J., Fyodorov, D. V. & Skoultchi, A. I., Apr 5 2013, In : Science. 340, 6128, p. 78-81 4 p.

Research output: Contribution to journalArticle

53 Scopus citations
8 Scopus citations