Research Output

Filter
Article
2017

FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres

Pan, X., Drosopoulos, W. C., Sethi, L., Madireddy, A., Schildkraut, C. L. & Zhang, D., Jul 18 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 29, p. E5940-E5949

Research output: Contribution to journalArticle

28 Scopus citations

Hispanic ethnicity is associated with younger age at presentation but worse survival in acute myeloid leukemia

Darbinyan, K., Shastri, A., Budhathoki, A., Helbig, D., Snyder, R., Pradhan, K., Saleh-Esa, J., Kornblum, N. S., Binder, A. F., Goel, S., Janakiram, M., Derman, O., Gritsman, K., Steidl, U., Braunschweig, I., Verma, A. & Mantzaris, I., Nov 14 2017, In : Blood Advances. 1, 24, p. 2120-2123 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Image-guided transplantation of single cells in the bone marrow of live animals

Turcotte, R., Alt, C., Runnels, J. M., Ito, K., Wu, J. W., Zaher, W., Mortensen, L. J., Silberstein, L., Côté, D. C., Kung, A. L., Ito, K. & Lin, C. P., Dec 1 2017, In : Scientific reports. 7, 1, 3875.

Research output: Contribution to journalArticle

3 Scopus citations

Lineage-Biased Stem Cells Maintain Estrogen-Receptor-Positive and -Negative Mouse Mammary Luminal Lineages

Wang, C., Christin, J. R., Oktay, M. H. & Guo, W., Mar 21 2017, In : Cell Reports. 18, 12, p. 2825-2835 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

Sawaguchi, S., Varshney, S., Ogawa, M., Sakaidani, Y., Yagi, H., Takeshita, K., Murohara, T., Kato, K., Sundaram, S., Stanley, P. & Okajima, T., Apr 11 2017, In : eLife. 6, e24419.

Research output: Contribution to journalArticle

35 Scopus citations

Pharmacological inhibition of the transcription factor PU.1 in leukemia

Antony-Debré, I., Paul, A., Leite, J., Mitchell, K., Kim, H. M., Carvajal, L. A., Todorova, T. I., Huang, K., Kumar, A., Farahat, A. A., Bartholdy, B. A., Narayanagari, S-R., Chen, J., Ambesi-Impiombato, A., Ferrando, A. A., Mantzaris, I., Gavathiotis, E., Verma, A. K., Will, B., Boykin, D. W. & 3 others, Wilson, W. D., Poon, G. M. K. & Steidl, U. G., Dec 1 2017, In : Journal of Clinical Investigation. 127, 12, p. 4297-4313 17 p.

Research output: Contribution to journalArticle

34 Scopus citations

Phase separation drives heterochromatin domain formation

Strom, A. R., Emelyanov, A., Mir, M., Fyodorov, D., Darzacq, X. & Karpen, G. H., Jul 13 2017, In : Nature. 547, 7662, p. 241-245 5 p.

Research output: Contribution to journalArticle

397 Scopus citations

Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation

Donnelly, S. K., Cabrera, R., Mao, S. P. H., Christin, J. R., Wu, B., Guo, W., Bravo-Cordero, J. J., Condeelis, J. S., Segall, J. E. & Hodgson, L., Jan 1 2017, In : Journal of Cell Biology. 216, 12, p. 4331-4349 19 p.

Research output: Contribution to journalArticle

19 Scopus citations

Regulatory functions and chromatin loading dynamics of linker histone H1 during endoreplication in Drosophila

Andreyeva, E. N., Bernardo, T. J., Kolesnikova, T. D., Lu, X., Yarinich, L. A., Bartholdy, B. A., Guo, X., Posukh, O. V., Healton, S., Willcockson, M. A., Pindyurin, A. V., Zhimulev, I. F., Skoultchi, A. I. & Fyodorov, D. V., Mar 15 2017, In : Genes & development. 31, 6, p. 603-616 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

STAT3 inhibition as a therapeutic strategy for leukemia

Kanna, R., Choudhary, G., Ramachandra, N., Steidl, U. G., Verma, A. K. & Shastri, A., Nov 23 2017, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-7 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

The ISWI ATPase Smarca5 (Snf2h) Is Required for Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells

Kokavec, J., Zikmund, T., Savvulidi, F., Kulvait, V., Edelmann, W., Skoultchi, A. I. & Stopka, T., Jun 2017, In : STEM CELLS. 35, 6, p. 1614-1623 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1

Wang, Y., Wu, B., Lu, P., Zhang, D., Wu, B., Varshney, S., Del Monte-Nieto, G., Zhuang, Z., Charafeddine, R., Kramer, A. H., Sibinga, N. E., Frangogiannis, N. G., Kitsis, R. N., Adams, R. H., Alitalo, K., Sharp, D. J., Harvey, R. P., Stanley, P. & Zhou, B., Dec 1 2017, In : Nature communications. 8, 1, 578.

Research output: Contribution to journalArticle

12 Scopus citations

ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPα

Gonzalez, D., Luyten, A., Bartholdy, B., Zhou, Q., Kardosova, M., Ebralidze, A., Swanson, K. D., Radomska, H. S., Zhang, P., Kobayashi, S. S., Welner, R. S., Levantini, E., Steidl, U., Chong, G., Collombet, S., Choi, M. H., Friedman, A. D., Scott, L. M., Alberich-Jorda, M. & Tenen, D. G., Nov 17 2017, In : Journal of Biological Chemistry. 292, 46, p. 18924-18936 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Adult T-Cell leukemia/lymphoma in the Caribbean cohort is a distinct clinical entity with dismal response to conventional chemotherapy

Zell, M., Assal, A., Derman, O., Kornblum, N., Battini, R., Wang, Y., Narasimhulu, D. M., Mantzaris, I., Shastri, A., Verma, A., Ye, H., Braunschweig, I. & Janakiram, M., Aug 1 2016, In : Oncotarget. 7, 32, p. 51981-51990 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Analysis of overall survival in a large multiethnic cohort reveals absolute neutrophil count of 1,100 as a novel prognostic cutoffin African Americans

Mantzaris, I., Yu, Y., Msaouel, P., Lam, A. P., Janakiram, M., Friedman, E. W., Steidl, U. & Verma, A. K., 2016, In : Oncotarget. 7, 42, p. 67948-67955 8 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

A novel chemotherapeutic agent to treat tumors with DNA mismatch repair deficiencies

Zhang, Y., Fox, J. T., Park, Y. U., Elliott, G., Rai, G., Cai, M., Sakamuru, S., Huang, R., Xia, M., Lee, K., Jeon, M. H., Mathew, B. P., Park, H. D., Edelmann, W., Park, C. Y., Hong, S. Y., Maloney, D. & Myung, K., Jul 15 2016, In : Cancer Research. 76, 14, p. 4183-4191 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL

Mai, Y., Yu, J. J., Bartholdy, B., Xu-Monette, Z. Y., Knapp, E. E., Yuan, F., Chen, H., Ding, B. B., Yao, Z., Das, B., Zou, Y., Young, K. H., Parekh, S. & Ye, B. H., Dec 15 2016, In : Blood. 128, 24, p. 2797-2807 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

A role for tuned levels of nucleosome remodeler subunit ACF1 during Drosophila oogenesis

Börner, K., Jain, D., Vazquez-Pianzola, P., Vengadasalam, S., Steffen, N., Fyodorov, D. V., Tomancak, P., Konev, A., Suter, B. & Becker, P. B., Mar 15 2016, In : Developmental Biology. 411, 2, p. 217-230 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

BEN domain protein Elba2 can functionally substitute for linker histone H1 in Drosophila in vivo

Xu, N., Lu, X., Kavi, H., Emelyanov, A. V., Bernardo, T. J., Vershilova, E., Skoultchi, A. I. & Fyodorov, D. V., Sep 30 2016, In : Scientific reports. 6, 34354.

Research output: Contribution to journalArticle

1 Scopus citations
91 Scopus citations

Calcium-Dependent Rubella Virus Fusion Occurs in Early Endosomes

Dubé, M., Etienne, L., Fels, M. & Kielian, M., 2016, In : Journal of Virology. 90, 14, p. 6303-6313 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation

He, S., Limi, S., McGreal, R. S., Xie, Q., Brennan, L. A., Kantorow, W. L., Kokavec, J., Majumdar, R., Hou, H., Edelmann, W., Liu, W., Ashery-Padan, R., Zavadil, J., Kantorow, M., Skoultchi, A. I., Stopka, T. & Cvekl, A., Jun 1 2016, In : Development (Cambridge). 143, 11, p. 1937-1947 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

Pietras, E. M., Mirantes-Barbeito, C., Fong, S., Loeffler, D., Kovtonyuk, L. V., Zhang, S., Lakshminarasimhan, R., Chin, C. P., Techner, J. M., Will, B., Nerlov, C., Steidl, U., Manz, M. G., Schroeder, T. & Passegué, E., Jun 1 2016, In : Nature Cell Biology. 18, 6, p. 607-618 12 p.

Research output: Contribution to journalArticle

150 Scopus citations

Distinct epigenetic features of differentiation-regulated replication origins

Smith, O. K., Kim, R., Fu, H., Martin, M. M., Lin, C. M., Utani, K., Zhang, Y., Marks, A. B., Lalande, M., Chamberlain, S., Libbrecht, M. W., Bouhassira, E. E., Ryan, M. C., Noble, W. S. & Aladjem, M. I., May 10 2016, In : Epigenetics and Chromatin. 9, 1, 18.

Research output: Contribution to journalArticle

22 Scopus citations

Enforced expression of hoxb4 in human embryonic stem cells enhances the production of hematopoietic progenitors but has no effect on the maturation of red blood cells

Jackson, M., Ma, R., Taylor, H., Axton, R. A., Easterbrook, J., Kydonaki, M., Olivier, E., Marenah, L., Stanley, E. G., Elefanty, A. G., Mountford, J. C. & Forrester, L. M., Aug 1 2016, In : Stem Cells Translational Medicine. 5, 8, p. 981-990 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

FANCD2 Facilitates Replication through Common Fragile Sites

Madireddy, A., Kosiyatrakul, S. T., Boisvert, R. A., Herrera-Moyano, E., García-Rubio, M. L., Gerhardt, J., Vuono, E. A., Owen, N., Yan, Z., Olson, S., Aguilera, A., Howlett, N. G. & Schildkraut, C. L., Oct 20 2016, In : Molecular Cell. 64, 2, p. 388-404 17 p.

Research output: Contribution to journalArticle

74 Scopus citations

Functional characterization of somatic mutations in cancer using network-based inference of protein activity

Alvarez, M. J., Shen, Y., Giorgi, F. M., Lachmann, A., Ding, B. B., Ye, B. H. & Califano, A., Aug 1 2016, In : Nature Genetics. 48, 8, p. 838-847 10 p.

Research output: Contribution to journalArticle

143 Scopus citations

Genomic landscape of colorectal mucosa and adenomas

Borras, E., Lucas, F. A. S., Chang, K., Zhou, R., Masand, G., Fowler, J., Mork, M. E., You, Y. N., Taggart, M. W., McAllister, F., Jones, D. A., Davies, G. E., Edelmann, W., Ehli, E. A., Lynch, P. M., Hawk, E. T., Capella, G., Scheet, P. & Vilar, E., Jun 2016, In : Cancer Prevention Research. 9, 6, p. 417-427 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV

Madireddy, A., Purushothaman, P., Loosbroock, C. P., Robertson, E. S., Schildkraut, C. L. & Verma, S. C., May 5 2016, In : Nucleic acids research. 44, 8, p. 3675-3694 20 p.

Research output: Contribution to journalArticle

31 Scopus citations

High-efficiency serum-free feeder-free erythroid differentiation of human pluripotent stem cells using small molecules

Olivier, E. N., Marenah, L., McCahill, A., Condie, A., Cowan, S. & Mountford, J. C., Oct 1 2016, In : Stem Cells Translational Medicine. 5, 10, p. 1394-1405 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

High prevalence and allele burden-independent prognostic importance of p53 mutations in an inner-city MDS/AML cohort

Goel, S., Hall, J., Pradhan, K., Hirsch, C., Przychodzen, B., Shastri, A., Mantzaris, I., Janakiram, M., Battini, R., Kornblum, N., Derman, O., Gritsman, K., Al-Hafidh, J., Wang, Y., Halmos, B., Steidl, U. G., Maciejewski, J. P., Braunschweig, I. & Verma, A. K., Apr 29 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

12 Scopus citations

Human transferrin receptor triggers an alternative Tacaribe virus internalization pathway

Roldán, J. S., Martínez, M. G., Forlenza, M. B., Whittaker, G. R. & Candurra, N. A., Feb 1 2016, In : Archives of Virology. 161, 2, p. 353-363 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
3 Scopus citations

Intercellular Extensions Are Induced by the Alphavirus Structural Proteins and Mediate Virus Transmission

Martinez, M. G. & Kielian, M., Dec 15 2016, In : PLoS Pathogens. 12, 12, e1006061.

Research output: Contribution to journalArticle

12 Scopus citations

Lunatic, manic, and radical fringe each promote T and B cell development

Song, Y., Vivek, K., Wei, H. X., Qiu, J. & Stanley, P., Jan 1 2016, In : Journal of Immunology. 196, 1, p. 232-243 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation

Zhang, Z., Christin, J. R., Wang, C., Ge, K., Oktay, M. H. & Guo, W., Sep 20 2016, In : Cell Reports. 16, 12, p. 3146-3156 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Metabolism and the Control of Cell Fate Decisions and Stem Cell Renewal

Ito, K. & Ito, K., Oct 6 2016, In : Annual Review of Cell and Developmental Biology. 32, p. 399-409 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Method for measuring the unbinding energy of strongly-bound membrane-associated proteins

La Bauve, E., Vernon, B. C., Ye, D., Rogers, D. M., Siegrist, C. M., Carson, B. D., Rempe, S. B., Zheng, A., Kielian, M., Shreve, A. P. & Kent, M. S., Nov 1 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 11, p. 2753-2762 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Molecular mechanism of mutant CALR–Mediated transformation

Stanley, R. F. & Steidl, U. G., Apr 1 2016, In : Cancer Discovery. 6, 4, p. 344-346 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mouse models of DNA mismatch repair in cancer research

Lee, K-R., Tosti, E. & Edelmann, W., Feb 1 2016, In : DNA Repair. 38, p. 140-146 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

MSH2 dysregulation is triggered by proinflammatory cytokine stimulation and is associated with liver cancer development

Eso, Y., Takai, A., Matsumoto, T., Inuzuka, T., Horie, T., Ono, K., Uemoto, S., Lee, K-R., Edelmann, W., Chiba, T. & Marusawa, H., Aug 1 2016, In : Cancer Research. 76, 15, p. 4383-4393 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pexmetinib: A novel dual inhibitor of Tie2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemia

Bachegowda, L., Morrone, K., Winski, S. L., Mantzaris, I., Bartenstein, M., Ramachandra, N., Giricz, O., Sukrithan, V., Nwankwo, G., Shahnaz, S., Bhagat, T. D., Bhattacharyya, S., Assal, A., Shastri, A., Gordon-Mitchell, S., Pellagatti, A., Boultwood, J., Schinke, C., Yu, Y., Guha, C. & 16 others, Rizzi, J., Garrus, J., Brown, S., Wollenberg, L., Hogeland, G., Wright, D., Munson, M., Rodriguez, M., Gross, S., Chantry, D., Zou, Y., Platanias, L. C., Burgess, L. E., Pradhan, K., Steidl, U. & Verma, A., Aug 15 2016, In : Cancer research. 76, 16, p. 4841-4849 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Pseudouridines in U2 snRNA stimulate the ATPase activity of Prp5 during spliceosome assembly

Wu, G., Adachi, H., Ge, J., Stephenson, D., Query, C. C. & Yu, Y. T., Mar 15 2016, In : EMBO Journal. 35, 6, p. 654-667 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Role of TSPAN9 in alphavirus entry and early endosomes

Stiles, K. M. & Kielian, M., May 1 2016, In : Journal of Virology. 90, 9, p. 4289-4297 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance

Ito, K., Turcotte, R., Cui, J., Zimmerman, S. E., Pinho, S. I., Mizoguchi, T., Arai, F., Runnels, J. M., Alt, C., Teruya-Feldstein, J., Mar, J. C., Singh, R., Suda, T., Lin, C. P., Frenette, P. S. & Ito, K., Oct 13 2016, (Accepted/In press) In : Science. p. 1-10 10 p.

Research output: Contribution to journalArticle

100 Scopus citations

SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing

Tang, Q., Rodriguez-Santiago, S., Wang, J., Pu, J., Yuste, A., Gupta, V., Moldón, A., Xu, Y. Z. & Query, C. C., Dec 15 2016, In : Genes and Development. 30, 24, p. 2710-2723 14 p.

Research output: Contribution to journalArticle

33 Scopus citations

SHP1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Differentiation

Jiang, M., Zheng, C., Shou, P., Li, N., Cao, G., Chen, Q., Xu, C., Du, L., Yang, Q., Cao, J., Han, Y., Li, F., Cao, W., Liu, F., Rabson, A. B., Roberts, A. I., Xie, W., Wang, Y. & Shi, Y., Jul 19 2016, In : Cell Reports. 16, 3, p. 769-780 12 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
11 Scopus citations

Thrombocytopenia in MDS: Epidemiology, mechanisms, clinical consequences and novel therapeutic strategies

Li, W., Morrone, K. A., Kambhampati, S., Will, B., Steidl, U. G. & Verma, A. K., Mar 1 2016, In : Leukemia. 30, 3, p. 536-544 9 p.

Research output: Contribution to journalArticle

20 Scopus citations
2015
5 Scopus citations