Biochemistry

Projects

Projects per year 1979 1989 1995 1997 2003 2004 2008 2009 2010 2014 2016 2017 2023

• 18 Active
• 275 Finished

Projects per year

Search results

• Research project

  Protein Dynamics in Enzymatic Catalysis

  Callender, R., Dyer, R. B., Schwartz, S., Schramm, V. L. & Callender, R.

  5/1/04 → 4/30/20

  Project: Research project

  • Protein 100%
  • Catalysis 77%
  • Proton Transfer 43%
  • Chemistry 42%
  • Schwartz Hydrozirconation 39%

• GLUT8 Overexpression in Cardioprotection

  Charron, M. J.

  National Heart, Lung, and Blood Institute

  5/5/09 → 4/30/10

  Project: Research project

  • heart 100%
  • glucose transporters 84%
  • ischemia 53%
  • cardiovascular diseases 53%
  • cardiomyopathy 45%

• GLUT4 AND CARDIAC METABOLISM AND PHYSIOLOGY

  Charron, M. J. & Rose, S. A.

  4/1/97 → 3/31/07

  Project: Research project

  • heart 100%
  • mice 90%
  • hypertrophy 76%
  • glucose 25%
  • magnetic resonance imaging 19%

• Molecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction

  Charron, M. M. J., Charron, M. J. & Fuloria, M.

  National Institute of Child Health and Human Development

  3/1/18 → 2/28/23

  Project: Research project

  • Pediatric Obesity 100%
  • Fetal Growth Retardation 97%
  • T-Lymphocytes 64%
  • DNA Methylation 58%
  • Obesity 37%

• Metabolomic Analysis of Redox control in Mycobacterium tuberculosis persisters

  Jacobs Jr., W. R., Kurland, I. J. & Wu, P.

  National Institute of Allergy and Infectious Diseases

  6/1/10 → 1/31/13

  Project: Research project

  • Mycobacterium tuberculosis 100%
  • Metabolomics 78%
  • Oxidation-Reduction 71%
  • Extensively Drug-Resistant Tuberculosis 26%
  • Citric Acid Cycle 22%

• Orbitrap Exploris 480 Basic System

  Sidoli, S.

  NIH Office of the Director

  5/15/21 → 5/14/22

  Project: Research project

  • Proteomics 100%
  • Microsporidia 20%
  • Research Personnel 18%
  • Myelodysplastic Syndromes 15%
  • Toxoplasma 15%

• GLUT8 Overexpression in Cardioprotection

  Charron, M. J. & Rose, S. A.

  5/5/09 → 4/30/11

  Project: Research project

  • heart 100%
  • glucose transporters 84%
  • ischemia 53%
  • cardiovascular diseases 53%
  • cardiomyopathy 45%

• Studies on Pol III-Associated Leukodystrophy

  Moir, R. D. & Willis, I. M.

  3/1/19 → 2/28/21

  Project: Research project

  • Mutation 100%
  • Anodontia 87%
  • Genetic Suppression 83%
  • RNA Polymerase III 82%
  • Developmental Disabilities 74%

• Molecular Basis of Insulin Resistance

  Charron, M. J. & Rose, S. A.

  4/1/08 → 8/31/10

  Project: Research project

  • metabolic syndrome 100%
  • noninsulin-dependent diabetes mellitus 93%
  • metabolic diseases 62%
  • high fat diet 56%
  • insulin resistance 38%

• Purine Pathways and Inhibitor Design in Plasmodium

  Schramm, V. L. & Schramm, V. L.

  National Institute of Allergy and Infectious Diseases

  8/1/02 → 4/30/13

  Project: Research project

  • Purine 100%
  • Plasmodium 96%
  • purines 85%
  • Transition State Structure 46%
  • Plasmodium falciparum 37%

• MECHANISM BASED INHIBITION OF M TUBERCULOSIS ENZYMES

  Blanchard, J. S. & Rose, S. A.

  9/30/92 → 2/28/14

  Project: Research project

  • Aspartate 100%
  • Chemistry 52%

• Inhibitors of Maf1-dependent transcriptional repression

  Willis, I. M.

  4/1/16 → 3/31/17

  Project: Research project

  • Anti-Obesity Agents 100%
  • Transfer RNA 76%
  • Obesity 72%
  • Genes 70%
  • Peptides 66%

• MAF1 Function and Metabolic Inefficiency

  Willis, I. M.

  9/21/16 → 7/31/21

  Project: Research project

  • Energy Metabolism 100%
  • RNA 95%
  • Transfer RNA 90%
  • RNA Polymerase III 76%
  • Untranslated RNA 62%

• Function and Mechanism of Viperin, a radical SAM antiviral protein

  Almo, S. C., Grove, T. L. & Almo, S. C.

  National Institute of Allergy and Infectious Diseases

  6/26/17 → 5/31/19

  Project: Research project

  • Cytidine Triphosphate 100%
  • S-Adenosylmethionine 89%
  • Antiviral Agents 61%
  • Viruses 38%
  • Interferons 26%

• Transcriptional Repression by Maf1 in Yeast

  Willis, I. M. & Rose, S. A.

  3/1/09 → 2/28/14

  Project: Research project

  • Transfer RNA 100%
  • RNA Polymerase III 94%
  • Ribosomes 71%
  • Nuclear RNA 61%
  • Yeasts 55%

• RIBONUCLEASE SUPERFAMILY--STRUCTURE-FUNCTION STUDIES

  Almo, S. C. & Almo, S. C.

  8/1/93 → 7/31/97

  Project: Research project

  • ribonucleases 100%
  • enzymology 50%
  • bioactive properties 46%
  • catalytic activity 34%
  • angiogenin 30%

• COLLABORATIVE CENTER FOR AN ENZYME FUNCTION INITIATIVE

  Almo, S. C., Jacobson, M., Cronan, J. E., Gerlt, J. & Cronan, J. E.

  5/20/10 → 4/30/17

  Project: Research project

  • enzymes 100%
  • metabolomics 57%
  • genome 46%
  • structural biology 41%
  • amide hydrolases 40%

• Technologies for Mapping the Extracellular Interactome

  Almo, S. C.

  9/24/15 → 6/30/19

  Project: Research project

  • Membrane Proteins 100%
  • Proteins 88%
  • Technology 78%
  • Automation 74%
  • Proteome 62%

• An integrated X-ray data collection system

  Almo, S. C. & Almo, S. C.

  NIH Office of the Director

  4/1/15 → 3/31/16

  Project: Research project

  • biology 100%
  • medicine 53%
  • biochemistry 17%
  • immunity 16%
  • physiology 15%

• Structure and Function of Arp 2/3 Complex

  Almo, S. C., Rosen, M., Volkmann, N., Pollard, T. D., Hanein, D., Rong, L. & Pollard, T. D.

  6/10/03 → 4/30/15

  Project: Research project

  • Actin-Related Protein 2-3 Complex 100%
  • Actin Cytoskeleton 33%
  • Nucleotides 21%
  • Peptides 17%
  • Single Molecule Imaging 9%

• STRUCTURAL BIOLOGY OF ACTIN CROSSLINKING PROTEINS

  Almo, S. C.

  9/30/96 → 8/31/02

  Project: Research project

• Protein/Structure Core

  Almo, S. C.

  National Institute of General Medical Sciences

  7/1/16 → 4/30/21

  Project: Research project

  • Proteins 100%
  • Oxygen 54%
  • Ligands 36%
  • Crystallization 30%
  • Carbohydrate Metabolism 29%

• Structural Biology

  Almo, S. S. C. & Almo, S. C.

  National Cancer Institute

  7/1/19 → 6/30/22

  Project: Research project

  • Proteomics 100%
  • Intellectual Property 41%
  • X-Rays 41%
  • Professional Competence 37%
  • Cryoelectron Microscopy 36%

• Core F: Structure

  Gerlt, J. A. & Almo, S. C.

  National Institute of General Medical Sciences

  5/20/10 → 4/30/16

  Project: Research project

  • crystallization 100%
  • ligand 87%
  • fold 61%
  • family 60%
  • aid 39%

• STRUCTURAL BIOLOGY OF THE ALLERGIC RESPONSE

  Almo, S. C.

  3/1/98 → 2/29/04

  Project: Research project

  • Epitopes 100%
  • Allergens 96%
  • IgE Receptors 58%
  • Cluster Analysis 52%
  • Receptor Aggregation 45%

• Catalytic and Inhibitory Mechanisms in Indoleamine 2,3-dioxygenase

  Yeh, S.

  National Institute of General Medical Sciences

  6/1/10 → 4/30/14

  Project: Research project

  • N-Formylkynurenine 100%
  • L-Tryptophan 79%
  • Chemistry 71%
  • Heme 56%
  • Antitumor 56%

• Glucose Meatbolism in the Human Ovary

  Charron, M. J. & Charron, M. J.

  National Institute of Child Health and Human Development

  1/20/03 → 12/31/03

  Project: Research project

  • Polycystic Ovary Syndrome 100%
  • Ovary 87%
  • Facilitative Glucose Transport Proteins 86%
  • Steroids 66%
  • Glucose 62%

• The NYSGRC: A Large Scale Center for PSI:Biology

  Almo, S. C., Fiser, A., Fiser, A., Seidel, R. R. D., Seidel, R. D., Almo, S. S. C. & Almo, S. C.

  National Institute of General Medical Sciences

  9/1/10 → 6/30/16

  Project: Research project

  • Immune Evasion 100%
  • Fungal Proteins 99%
  • Bacterial Proteins 96%
  • Cell Biology 68%
  • Organizations 66%

• COLLABORATIVE CENTER FOR AN ENZYME FUNCTION INITIATIVE

  Gerlt, J. A., Almo, S. C., Cronan, J. E., Jacobson, M. P. & Gerlt, J. A.

  5/20/10 → 4/30/17

  Project: Research project

  • enzymes 100%
  • metabolomics 57%
  • genome 46%
  • structural biology 41%
  • amide hydrolases 40%

• EXPRESSION CONTROL OF YEAST GLUCOAMYLASE GENES

  Willis, I. M. & Marmur, J.

  National Institute of General Medical Sciences

  5/1/92 → 4/30/95

  Project: Research project

  • glucan 1,4-alpha-glucosidase 100%
  • genes 83%
  • gene expression 73%
  • Saccharomyces cerevisiae 49%
  • clones 27%

• Inhibitors of Maf1-dependent transcriptional repression

  Willis, I. M.

  National Institute of General Medical Sciences

  4/1/16 → 3/31/17

  Project: Research project

  • Anti-Obesity Agents 100%
  • Transfer RNA 76%
  • Obesity 72%
  • Genes 70%
  • Peptides 66%

• MAF1 Function and Metabolic Inefficiency

  Willis, I. M. & Willis, I. M.

  National Institute of General Medical Sciences

  9/21/16 → 7/31/21

  Project: Research project

  • Energy Metabolism 100%
  • RNA 95%
  • Transfer RNA 90%
  • RNA Polymerase III 76%
  • Untranslated RNA 62%

• Ligand Discovery Project

  Almo, S. C.

  National Institute of General Medical Sciences

  7/1/16 → 4/30/21

  Project: Research project

  • Carrier Proteins 100%
  • Ligands 83%
  • Metabolic Networks and Pathways 29%
  • Microbiota 29%
  • Gastrointestinal Microbiome 29%

• Cancer Research Career Enhancement and Related Activities (CRCE)

  Bresnick, A. A. R. & Bresnick, A. R.

  National Cancer Institute

  7/1/19 → 6/30/22

  Project: Research project

  • Neoplasms 100%
  • Education 57%
  • Medical Oncology 43%
  • Students 25%
  • Pediatrics 23%

• Novel Strategies for the Discovery of Microbial Metabolic Pathways

  Gerlt, J. A., Almo, S. C. & Jacobson, M. P.

  6/15/16 → 4/30/21

  Project: Research project

  • Solute 100%
  • Metabolic 79%
  • Ligand 74%
  • Protein 70%
  • Enzyme Activity 40%

• Old Drugs and New Strategies for Tumor Metastasis

  Bresnick, A. R.

  8/4/08 → 4/30/13

  Project: Research project

  • Neoplasm Metastasis 100%
  • Neoplasms 82%
  • Nonmuscle Myosin Type IIA 75%
  • Calcium-Binding Proteins 57%
  • Psychological Inhibition 56%

• STRUCTURAL BIOLOGY SHARED RESOURCE

  Gupta, R. K., Gupta, R. R. K., Chance, M. R., Almo, S. S. C. & Almo, S. C.

  National Cancer Institute

  10/1/85 → 6/30/12

  Project: Research project

  • Crystallization 100%
  • Cryo-Electron Microscopy 94%
  • Mammalian Cell 74%
  • Solid-State NMR 73%
  • Photon 68%

• PROFILIN--STRUCTURE/FUNCTION RELATIONSHIPS

  Almo, S. C.

  9/30/95 → 4/30/05

  Project: Research project

  • Profilins 100%
  • Nucleotides 25%
  • Phosphatidylinositols 22%
  • Actins 22%
  • Second Messenger Systems 11%

• NYSGXRC:A Large Scale Center for the PSI

  Almo, S. C., Sali, A., Lima, C., Shapiro, L., Swaminathan, S. & Burley, S. K.

  7/1/05 → 6/30/11

  Project: Research project

  • protein structure 100%
  • wavelengths 90%
  • structural genomics 69%
  • Escherichia coli 61%
  • protein solubility 59%

• INTEGRATED XRAY IMAGE PLATE DETECTOR SYSTEM

  Almo, S. C.

  1/20/99 → 1/19/00

  Project: Research project

  • Detectors 100%
  • X rays 87%
  • Medicine 64%
  • Industrial laboratories 53%
  • Industrial research 45%

• Structural basis of allostery and mechanical properties of F-actin

  Almo, S. C.

  8/1/16 → 7/31/20

  Project: Research project

  • Actins 100%
  • Microfilament Proteins 66%
  • Protein Subunits 57%
  • Cryoelectron Microscopy 45%
  • Protein Binding 33%

• Signaling and Motility Assays

  Bresnick, A. R.

  National Cancer Institute

  6/1/09 → 5/31/13

  Project: Research project

  • Neoplasms 100%
  • Stromal Cells 78%
  • Transendothelial and Transepithelial Migration 52%
  • In Vitro Techniques 50%
  • Biosensing Techniques 47%

• Technologies for Mapping the Extracellular Interactome

  Almo, S. C. & Almo, S. C.

  National Human Genome Research Institute

  9/24/15 → 6/30/19

  Project: Research project

  • Technology 100%
  • Membrane Proteins 70%
  • Proteins 62%
  • Automation 52%
  • Proteome 44%

• Molecular Basis of Insulin Resistance

  Charron, M. J. & Charron, M. J.

  National Institute of Diabetes and Digestive and Kidney Diseases

  4/1/08 → 3/31/10

  Project: Research project

  • metabolic syndrome 100%
  • noninsulin-dependent diabetes mellitus 93%
  • insulin resistance 72%
  • metabolic diseases 62%
  • high fat diet 56%

• Glucose Meatbolism in the Human Ovary

  Charron, M. J. & Rose, S. A.

  1/20/03 → 12/31/05

  Project: Research project

  • Polycystic Ovary Syndrome 100%
  • Facilitative Glucose Transport Proteins 86%
  • Ovary 78%
  • Steroids 66%
  • Glucose 56%

• GLUT4 AND GLUCOSE HOMEOSTASIS

  Charron, M. J. & Rose, S. A.

  8/1/95 → 11/30/09

  Project: Research project

  • mice 100%
  • insulin resistance 98%
  • glucose 96%
  • insulin 93%
  • skeletal muscle 73%

• Functional Consequences of Impaired Autophagy in Aging

  Santambrogio, L., Macian-Juan, F., Cuervo, A. M., Cuervo, A. M., Singh, R., Rose, S. A., Gavathiotis, E. & Bravo Cordero, J. J.

  2/15/09 → 3/31/22

  Project: Research project

  • autophagy 100%
  • cognition 24%
  • T-lymphocytes 19%
  • bookkeeping 18%
  • organisms 18%

• Altered Glucose and Lipid Metabolism in Obesity and CVD

  Charron, M. J. & Rose, S. A.

  8/1/03 → 7/31/09

  Project: Research project

  • White Adipose Tissue 100%
  • Abdominal Obesity 92%
  • Cardiovascular Diseases 89%
  • Lipid Metabolism 59%
  • Obesity 57%

• Development of Diabetic Cardiomyopathy in GLUT4 +/- Mice

  Charron, M. J. & Charron, M. J.

  National Heart, Lung, and Blood Institute

  4/1/97 → 3/31/04

  Project: Research project

  • cardiomyopathy 100%
  • heart 80%
  • mice 65%
  • insulin 63%
  • thiazolidinediones 58%

• Structures of time-resolved intermediates in cytochrome c oxidase obtained by serial femtosecond crystallography

  Rousseau, D. L., Yeh, S. & Rousseau, D. L.

  National Institute of General Medical Sciences

  9/15/17 → 8/31/21

  Project: Research project

  • Crystallography 100%
  • Cytochrome 94%
  • Proton 57%
  • Carbon Monoxide 45%
  • X-Ray Crystallography 29%