Biochemistry

Projects

Projects per year 1979 1989 1997 2004 2008 2009 2010 2014 2015 2016 2017 2023

• 26 Active
• 196 Finished

Projects per year

Search results

• Lectimers: Glycan-anchored scaffold libraries for targeting carbohydrate-binding

  Levy, M.

  9/20/13 → 8/31/17

  Project: Research project

  • Nucleic Acid 100%
  • Carbohydrate 65%
  • Protein 65%
  • Ligand 34%
  • Peptide 22%

• Regulation of the Class IA PI 3-kinase PIK3CB

  Bresnick, A. R., Backer, J. M. & Bresnick, A. R.

  9/5/14 → 7/31/18

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • G-Protein-Coupled Receptors 36%
  • Neoplasms 18%
  • Growth 18%
  • Neoplasm Metastasis 13%

• Regulation of the Class IA PI 3-kinase PIK3CB

  Backer, J. M. & Bresnick, A. R.

  National Institute of General Medical Sciences

  9/5/14 → 7/31/18

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • G-Protein-Coupled Receptors 38%
  • Neoplasms 19%
  • Growth 19%
  • Neoplasm Metastasis 14%

• Engineered Dengue EDIIIs as Broad Immunogens

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  1/1/17 → 12/31/18

  Project: Research project

  • Broadly Neutralizing Antibodies 100%
  • Dengue 94%
  • Serogroup 80%
  • Subunit Vaccines 64%
  • Glycoproteins 60%

• Engineered Dengue EDIIIs as Broad Immunogens

  Lai, J. R.

  1/1/17 → 12/31/18

  Project: Research project

  • Broadly Neutralizing Antibodies 100%
  • Serogroup 80%
  • Subunit Vaccines 64%
  • Glycoproteins 60%
  • Infections 50%

• Chemical tools for studying membrane protein glycosylation

  Ovryn, B. & Wu, P.

  National Institute of General Medical Sciences

  4/15/15 → 3/31/19

  Project: Research project

  • Glycosylation 100%
  • Polysaccharides 64%
  • Membrane Proteins 61%
  • Glycoproteins 39%
  • Neoplasms 29%

• Chemical tools for studying membrane protein glycosylation

  Ovryn, B. & Wu, P.

  National Institutes of Health

  4/15/15 → 3/31/19

  Project: Research project

  • Glycosylation 100%
  • Membrane Proteins 73%
  • Polysaccharides 60%
  • Glycoproteins 37%
  • Neoplasms 28%

• Function and Mechanism of Viperin, a radical SAM antiviral protein

  Almo, S. C. & Grove, T. L.

  National Institute of Allergy and Infectious Diseases

  6/26/17 → 5/31/19

  Project: Research project

  • Cytidine Triphosphate 100%
  • S-Adenosylmethionine 89%
  • Antiviral Agents 61%
  • Viruses 38%
  • Interferons 26%

• Function and Mechanism of Viperin, a radical SAM antiviral protein

  Almo, S. C.

  6/26/17 → 5/31/19

  Project: Research project

  • Cytidine Triphosphate 100%
  • S-Adenosylmethionine 74%
  • Antiviral Agents 61%
  • Viruses 38%
  • Interferons 26%

• Consortium for Immunotherapeutics Against Viral Hemorrhagic Fevers

  Lai, J. R., Chandran, K., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A. & Rose, S. A.

  3/15/14 → 6/28/19

  Project: Research project

  • Antibodies 100%
  • Arenavirus 87%
  • Filoviridae 85%
  • Viral Hemorrhagic Fevers 43%
  • Monoclonal Antibodies 30%

• Technologies for Mapping the Extracellular Interactome

  Almo, S. C.

  National Human Genome Research Institute

  9/24/15 → 6/30/19

  Project: Research project

  • Technology 100%
  • Membrane Proteins 70%
  • Proteins 62%
  • Automation 52%
  • Proteome 44%

• Technologies for Mapping the Extracellular Interactome

  Almo, S. C.

  9/24/15 → 6/30/19

  Project: Research project

  • Membrane Proteins 100%
  • Proteins 88%
  • Technology 78%
  • Automation 74%
  • Proteome 62%

• Chemoenzymatic methods for the detection of cell-surface glycans

  Wu, P.

  National Institutes of Health

  8/15/15 → 7/31/19

  Project: Research project

  • Polysaccharides 100%
  • Glycosylation 49%
  • Lectins 17%
  • Glycomics 12%
  • Lung Neoplasms 11%

• Studies on Pol III-Associated Leukodystrophy

  Moir, R. D. & Willis, I. M.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  3/1/19 → 2/29/20

  Project: Research project

  • Mutation 100%
  • Anodontia 87%
  • Genetic Suppression 83%
  • RNA Polymerase III 82%
  • Developmental Disabilities 74%

• Time-resolved small angle X-ray scattering

  Brenowitz, M. D., Pollack, L., Steven, C., Altman, R. B., Doniach, S. & Herschlag, D.

  1/1/01 → 3/31/20

  Project: Research project

  • folding 100%
  • x ray scattering 36%
  • scattering 16%
  • probes 13%
  • characterization 12%

• Transition State Analogues as Modulators of DNA Methylation

  Schramm, V. L., Rose, S. A. & Rose, S. A.

  9/11/08 → 4/30/20

  Project: Research project

  • 5'-methylthioadenosine phosphorylase 100%
  • DNA Methylation 46%
  • Neoplasms 39%
  • CpG Islands 34%
  • Methyltransferases 31%

• Protein Dynamics in Enzymatic Catalysis

  Callender, R., Dyer, R. B., Schwartz, S., Schramm, V. L. & Callender, R.

  5/1/04 → 4/30/20

  Project: Research project

  • Protein 100%
  • Catalysis 77%
  • Proton Transfer 43%
  • Chemistry 42%
  • Schwartz Hydrozirconation 39%

• Bacterial N-Acetyltransferases: Resistance to Regulation

  Blanchard, J. S., Rose, S. A. & Rose, S. A.

  5/1/04 → 4/30/20

  Project: Research project

  • Acetyltransferases 100%
  • Acetylation 67%
  • ribosomal protein S18 51%
  • ribosomal protein S5 48%
  • aminoglycoside acetyltransferase 48%

• Bacterial N-Acetyltransferases: Resistance to Regulation

  Blanchard, J. S.

  National Institute of Allergy and Infectious Diseases

  5/1/04 → 4/30/20

  Project: Research project

  • Acetyltransferases 100%
  • Mycobacterium tuberculosis 27%
  • Proteins 27%
  • Acetylation 23%
  • ribosomal protein S18 14%

• Methylthioadenosine Phosphorylase and AdoMet Synthetase in Cancer

  Schramm, V. L.

  National Cancer Institute

  9/11/08 → 4/30/20

  Project: Research project

  • DNA Methylation 100%
  • Transition State 88%
  • Human Metabolite 84%
  • 5'-methylthioadenosine phosphorylase 82%
  • Effective Dose 78%

• Protein Dynamics in Enzymatic Catalysis

  Callender, R.

  National Institute of General Medical Sciences

  5/1/04 → 4/30/20

  Project: Research project

  • Catalysis 100%
  • Enzymes 85%
  • Proteins 73%
  • Protein 22%
  • Enzyme inhibition 13%

• Tumor Progression and Metastasis

  Bresnick, A. R., Pollard, J. W., Segall, J. E., Backer, J. M., Condeelis, J. S., Pollard, J. W., Condeelis, J. S., Backer, J. M. & Bresnick, A. R.

  1/1/01 → 5/31/20

  Project: Research project

• Novel Strategies for Precision T-cell Therapies

  Almo, S. C.

  National Cancer Institute

  6/1/16 → 5/31/20

  Project: Research project

  • Immunological Synapses 100%
  • Cell- and Tissue-Based Therapy 75%
  • T-Lymphocytes 53%
  • Biological Products 37%
  • Peptides 18%

• Engineered, multispecific antibodies as broad anti-filovirus therapeutics

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  6/1/17 → 5/31/20

  Project: Research project

  • Filoviridae 100%
  • Ebolavirus 47%
  • Monoclonal Antibodies 46%
  • Antibodies 30%
  • Marburgvirus 27%

• A Trojan Horse bispecific antibody strategy for broad filovirus therapeutics

  Chandran, K. & Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  7/14/17 → 6/30/20

  Project: Research project

  • Filoviridae 100%
  • Bispecific Antibodies 78%
  • Monoclonal Antibodies 36%
  • Ebolavirus 28%
  • Sudan 18%

• Chemoenzymatic methods for the detection of cellsurface glycans

  Wu, P.

  National Institute of General Medical Sciences

  8/15/15 → 7/31/20

  Project: Research project

  • Polysaccharides 100%
  • Glycosylation 48%
  • Lectins 16%
  • Lung Neoplasms 12%
  • Glycomics 11%

• The dynamic mechanism of nuclear transport visualized at the atomic scale

  Cowburn, D.

  National Institute of General Medical Sciences

  3/1/16 → 7/31/20

  Project: Research project

  • porosity 100%
  • macromolecules 86%
  • neoplasms 44%
  • nuclear magnetic resonance 43%
  • interactions 43%

• Chemical tools for studying fucosylated glycans

  Wu, P.

  National Institutes of Health

  9/15/10 → 7/31/20

  Project: Research project

  • Fucoside 100%
  • Microarrays 22%
  • Lipid 13%
  • Guanidine 11%
  • Bilayer Membrane 11%

• Structural basis of allostery and mechanical properties of F-actin

  Almo, S. C.

  8/1/16 → 7/31/20

  Project: Research project

  • Actins 100%
  • Microfilament Proteins 66%
  • Protein Subunits 57%
  • Cryoelectron Microscopy 45%
  • Protein Binding 33%

• Structural basis of allostery and mechanical properties of F-actin

  Almo, S. C., Hanein, D. & Volkmann, N.

  National Institute of General Medical Sciences

  8/1/16 → 7/31/20

  Project: Research project

  • Actins 100%
  • Microfilament Proteins 71%
  • Protein Subunits 62%
  • Cryoelectron Microscopy 49%
  • Protein Binding 36%

• An immunotherapeutic strategy for the induction and stabilization of remission in type 1 diabetes

  Almo, S. C. & DiLorenzo, T. P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/15/18 → 7/31/20

  Project: Research project

  • Remission Induction 100%
  • Type 1 Diabetes Mellitus 70%
  • T-Lymphocytes 57%
  • Antigens 29%
  • Immunological Synapses 27%

• Studies on Pol III-Associated Leukodystrophy

  Moir, R. D. & Willis, I. M.

  3/1/19 → 2/28/21

  Project: Research project

  • Mutation 100%
  • Anodontia 87%
  • Genetic Suppression 83%
  • RNA Polymerase III 82%
  • Developmental Disabilities 74%

• Novel Strategies for the Discovery of Microbial Metabolic Pathways

  Almo, S. C.

  5/1/20 → 4/30/21

  Project: Research project

  • Solute 100%
  • Metabolic 79%
  • Ligand 74%
  • Protein 70%
  • Enzyme Activity 40%

• Engineered, multispecific antibodies as broad anti-filovirus therapeutics

  Lai, J. R.

  6/1/17 → 5/31/21

  Project: Research project

  • Filoviridae 100%
  • Ebolavirus 43%
  • Monoclonal Antibodies 43%
  • Marburgvirus 25%
  • Viruses 18%

• Project-001

  Almo, S. C.

  1/1/01 → 5/31/21

  Project: Research project

  • Immunological Synapses 100%
  • T-Lymphocytes 53%
  • Biological Products 37%
  • Peptides 18%
  • Cell- and Tissue-Based Therapy 18%

• A Trojan Horse bispecific antibody strategy for broad filovirus therapeutics

  Lai, J. R. & Chandran, K.

  7/14/17 → 6/30/21

  Project: Research project

  • Filoviridae 100%
  • Monoclonal Antibodies 33%
  • Bispecific Antibodies 27%
  • Ebolavirus 26%
  • Sudan 17%

• Chemical Tools for Studying Fucosylated Glycans

  Wu, P.

  National Institute of General Medical Sciences

  9/15/10 → 7/31/21

  Project: Research project

  • Fucoside 100%
  • Microarrays 22%
  • Lipid 13%
  • Guanidine 11%
  • Bilayer Membrane 11%

• The Role of PI3Kbeta in Breast Cancer Metastasis

  Backer, J. M. & Bresnick, A. R.

  8/1/16 → 7/31/21

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Breast Neoplasms 46%
  • Neoplasm Metastasis 44%
  • G-Protein-Coupled Receptors 43%
  • Podosomes 43%

• The Role of PI3Kbeta in Breast Cancer Metastasis

  Backer, J. M. & Bresnick, A. R.

  National Institute of General Medical Sciences

  8/1/16 → 7/31/21

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Breast Neoplasms 61%
  • Neoplasm Metastasis 59%
  • G-Protein-Coupled Receptors 43%
  • Podosomes 43%

• MAF1 Function and Metabolic Inefficiency

  Willis, I. M.

  National Institute of General Medical Sciences

  9/21/16 → 7/31/21

  Project: Research project

  • Energy Metabolism 100%
  • RNA 95%
  • Transfer RNA 90%
  • RNA Polymerase III 76%
  • Untranslated RNA 62%

• TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONS

  Schramm, V. L., Rose, S. A., Rose, S. A. & Schramm, V. L.

  12/31/89 → 7/31/21

  Project: Research project

  • Purine Nucleoside 100%
  • Transition State Structure 98%
  • Transition State 76%
  • Kinetic Isotope Effect 67%
  • Purine 62%

• MAF1 Function and Metabolic Inefficiency

  Willis, I. M.

  9/21/16 → 7/31/21

  Project: Research project

  • Energy Metabolism 100%
  • RNA 95%
  • Transfer RNA 90%
  • RNA Polymerase III 76%
  • Untranslated RNA 62%

• The dynamic mechanism of nuclear transport visualized at the atomic scale

  Cowburn, D.

  3/1/16 → 7/31/21

  Project: Research project

  • porosity 100%
  • macromolecules 86%
  • neoplasms 44%
  • nuclear magnetic resonance 43%
  • interactions 43%

• PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE

  Schramm, V. L. & Schramm, V. L.

  9/25/17 → 8/31/21

  Project: Research project

  • Purine 100%
  • Hypoxanthine 20%
  • Parasitic 20%
  • Nucleotide 13%
  • Transition State 13%

• PRMT5-MEP50 Histone Arginine Methylation in Early Development

  Shechter, D.

  9/1/14 → 8/31/21

  Project: Research project

  • histones 100%
  • methylation 64%
  • protein arginine methyltransferases 23%
  • early development 19%
  • arginine 17%

• Allosteric inhibitors targeting oncogenic BRAF V600E dimers

  Gavathiotis, E.

  National Cancer Institute

  12/1/20 → 11/30/21

  Project: Research project

  • ponatinib 100%
  • Thyroid Neoplasms 48%
  • Melanoma 40%
  • Colorectal Neoplasms 38%
  • Dimerization 27%