Biochemistry

Projects

Projects per year 1979 1989 1997 2004 2008 2009 2010 2014 2016 2017 2019 2023

• 10 Active
• 243 Finished

Projects per year

Search results

• In vivo imaging of X inactivation

  Greally, J. M., Levy, M., Rose, S. A., Rose, S. A., Rose, S. A. & Rose, S. A.

  9/15/10 → 5/31/16

  Project: Research project

  • inactivation 100%
  • X chromosome 51%
  • image analysis 35%
  • epigenetics 35%
  • cells 27%

• In vivo imaging of X inactivation

  Greally, J. M., Levy, M. & Greally, J. M.

  National Institute on Drug Abuse

  9/15/10 → 5/31/16

  Project: Research project

  • inactivation 100%
  • image analysis 90%
  • epigenetics 52%
  • X chromosome 42%
  • histone code 26%

• Orally available transition state inhibitors for triple negative breast cancer

  Isaacman, S., Schramm, V. L., Rose, S. A. & Rose, S. A.

  1/1/14 → 6/30/16

  Project: Research project

  • 5'-methylthioadenosine phosphorylase 100%
  • Triple Negative Breast Neoplasms 85%
  • 5'-methylthioadenosine 25%
  • National Institutes of Health (U.S.) 14%
  • Neoplasms 13%

• Orally available transition state inhibitors for triple negative breast cancer

  Isaacman, S. & Schramm, V. L.

  National Cancer Institute

  7/1/14 → 6/30/16

  Project: Research project

  • Triple Negative Breast Neoplasms 100%
  • 5'-methylthioadenosine phosphorylase 83%
  • Breast Neoplasms 30%
  • Neoplasms 26%
  • 5'-methylthioadenosine 20%

• The NYSGRC: A Large Scale Center for PSI:Biology

  Almo, S. C. & Fiser, A.

  National Institute of General Medical Sciences

  9/1/10 → 6/30/16

  Project: Research project

  • Immune Evasion 100%
  • Fungal Proteins 99%
  • Bacterial Proteins 96%
  • Cell Biology 68%
  • Organizations 66%

• The NYSGRC: A Large Scale Center for PSI:Biology

  Seidel, R. D., Fiser, A., Almo, S. C., Almo, S. C., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A. & Rose, S. A.

  9/1/10 → 6/30/16

  Project: Research project

  • Immune Evasion 100%
  • Fungal Proteins 99%
  • Bacterial Proteins 96%
  • Health 77%
  • Cell Biology 68%

• Inhibitors of Maf1-dependent transcriptional repression

  Willis, I. M.

  National Institute of General Medical Sciences

  4/1/16 → 3/31/17

  Project: Research project

  • Anti-Obesity Agents 100%
  • Transfer RNA 76%
  • Obesity 72%
  • Genes 70%
  • Peptides 66%

• Inhibitors of Maf1-dependent transcriptional repression

  Willis, I. M.

  4/1/16 → 3/31/17

  Project: Research project

  • Anti-Obesity Agents 100%
  • Transfer RNA 76%
  • Obesity 72%
  • Genes 70%
  • Peptides 66%

• COLLABORATIVE CENTER FOR AN ENZYME FUNCTION INITIATIVE

  Gerlt, J. A., Almo, S. C., Cronan, J. E., Jacobson, M. P. & Gerlt, J. A.

  5/20/10 → 4/30/17

  Project: Research project

  • enzymes 100%
  • metabolomics 57%
  • genome 46%
  • structural biology 41%
  • amide hydrolases 40%

• COLLABORATIVE CENTER FOR AN ENZYME FUNCTION INITIATIVE

  Almo, S. C., Jacobson, M., Cronan, J. E., Gerlt, J. & Cronan, J. E.

  5/20/10 → 4/30/17

  Project: Research project

  • enzymes 100%
  • metabolomics 57%
  • genome 46%
  • structural biology 41%
  • amide hydrolases 40%

• Broadly Protective Bispecific Antibodies for Treatment of Ebola Virus Disease

  Aman, J. M. & Lai, J. R.

  7/5/16 → 6/30/17

  Project: Research project

  • Filoviridae 100%
  • Bispecific Antibodies 81%
  • Epitopes 37%
  • Ebolavirus 29%
  • Antibodies 27%

• Broadly Protective Bispecific Antibodies for Treatment of Ebola Virus Disease

  Lai, J. R.

  7/5/16 → 6/30/17

  Project: Research project

  • Filoviridae 100%
  • Bispecific Antibodies 81%
  • Epitopes 37%
  • Ebolavirus 29%
  • Antibodies 27%

• Lectimers: Glycan-anchored scaffold libraries for targeting carbohydrate-binding

  Levy, M. & Levy, M.

  National Cancer Institute

  9/20/13 → 8/31/17

  Project: Research project

  • Nucleic Acid 100%
  • Carbohydrate 65%
  • Protein 65%
  • Ligand 34%
  • Peptide 22%

• Lectimers: Glycan-anchored scaffold libraries for targeting carbohydrate-binding

  Levy, M.

  9/20/13 → 8/31/17

  Project: Research project

  • Nucleic Acid 100%
  • Carbohydrate 65%
  • Protein 65%
  • Ligand 34%
  • Peptide 22%

• Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis

  Catz, S. D., Cherqui, S., Cuervo, A. M. & Gavathiotis, E.

  National Institute of Diabetes and Digestive and Kidney Diseases

  8/9/17 → 4/30/18

  Project: Research project

  • Chaperone-Mediated Autophagy 100%
  • Cystinosis 92%
  • Lysosomal Storage Diseases 43%
  • Cystine 33%
  • Cysteamine 12%

• Signaling, Motility and TEM Assays

  Bresnick, A. R.

  National Cancer Institute

  6/1/14 → 5/31/18

  Project: Research project

  • Stromal Cells 100%
  • Biosensing Techniques 80%
  • Transendothelial and Transepithelial Migration 44%
  • In Vitro Techniques 43%
  • Neoplasms 42%

• Regulation of the Class IA PI 3-kinase PIK3CB

  Backer, J. M. & Bresnick, A. R.

  National Institute of General Medical Sciences

  9/5/14 → 7/31/18

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • G-Protein-Coupled Receptors 38%
  • Neoplasms 19%
  • Growth 19%
  • Neoplasm Metastasis 14%

• Regulation of the Class IA PI 3-kinase PIK3CB

  Bresnick, A. R., Backer, J. M. & Bresnick, A. R.

  9/5/14 → 7/31/18

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • G-Protein-Coupled Receptors 36%
  • Neoplasms 18%
  • Growth 18%
  • Neoplasm Metastasis 13%

• Engineered Dengue EDIIIs as Broad Immunogens

  Lai, J. R.

  1/1/17 → 12/31/18

  Project: Research project

  • Broadly Neutralizing Antibodies 100%
  • Serogroup 80%
  • Subunit Vaccines 64%
  • Glycoproteins 60%
  • Infections 50%

• Engineered Dengue EDIIIs as Broad Immunogens

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  1/1/17 → 12/31/18

  Project: Research project

  • Broadly Neutralizing Antibodies 100%
  • Serogroup 80%
  • Dengue 80%
  • Subunit Vaccines 64%
  • Glycoproteins 60%

• Immunotherapeutics Against Other Filovirus Threats

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  3/1/18 → 2/28/19

  Project: Research project

  • Filoviridae 100%
  • Ebolavirus 96%
  • Marburgvirus 72%
  • Monoclonal Antibodies 47%
  • Primates 30%

• Chemical tools for studying membrane protein glycosylation

  Ovryn, B., Wu, P. & Wu, P.

  National Institute of General Medical Sciences

  4/15/15 → 3/31/19

  Project: Research project

  • Glycosylation 100%
  • Polysaccharides 64%
  • Membrane Proteins 61%
  • Glycoproteins 39%
  • Neoplasms 29%

• Chemical tools for studying membrane protein glycosylation

  Ovryn, B. & Wu, P.

  National Institutes of Health

  4/15/15 → 3/31/19

  Project: Research project

  • Glycosylation 100%
  • Membrane Proteins 73%
  • Polysaccharides 60%
  • Glycoproteins 37%
  • Neoplasms 28%

• Protein architecture and Energy Landscape of Enzymes

  Callender, R.

  National Institute of General Medical Sciences

  8/15/14 → 4/30/19

  Project: Research project

  • energy 100%
  • enzymes 75%
  • phosphorylase 64%
  • nucleosides 60%
  • proteins 58%

• Dynamics in enzymatic catalysis and transition state analogue binding.

  Schramm, V. L.

  National Institute of General Medical Sciences

  8/15/14 → 4/30/19

  Project: Research project

  • Nucleoside 100%
  • Catalysis 62%
  • Transition State 44%
  • Kinetic Isotope Effect 39%
  • Lactate 36%

• Administrative Core.

  Callender, R.

  National Institute of General Medical Sciences

  8/15/14 → 4/30/19

  Project: Research project

  • travel 100%
  • management 55%
  • performance 52%
  • student 28%

• Function and Mechanism of Viperin, a radical SAM antiviral protein

  Almo, S. C., Grove, T. L. & Almo, S. C.

  National Institute of Allergy and Infectious Diseases

  6/26/17 → 5/31/19

  Project: Research project

  • Cytidine Triphosphate 100%
  • S-Adenosylmethionine 87%
  • Antiviral Agents 61%
  • Viruses 38%
  • Interferons 26%

• Function and Mechanism of Viperin, a radical SAM antiviral protein

  Almo, S. C.

  6/26/17 → 5/31/19

  Project: Research project

  • Cytidine Triphosphate 100%
  • S-Adenosylmethionine 74%
  • Antiviral Agents 61%
  • Viruses 38%
  • Interferons 26%

• Consortium for Immunotherapeutics Against Viral Hemorrhagic Fevers

  Saphire, E. O., Chandran, K., Garry, R. F., Lai, J. R., Lai, J. R. & Zeitlin, L.

  3/15/14 → 6/28/19

  Project: Research project

  • Arenavirus 100%
  • Filoviridae 98%
  • Antibodies 97%
  • Monoclonal Antibodies 34%
  • Investigational New Drug Application 27%

• Consortium for Immunotherapeutics Against Viral Hemorrhagic Fevers

  Lai, J. R., Chandran, K., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A. & Rose, S. A.

  3/15/14 → 6/28/19

  Project: Research project

  • Antibodies 100%
  • Arenavirus 87%
  • Filoviridae 85%
  • Viral Hemorrhagic Fevers 43%
  • Monoclonal Antibodies 30%

• Technologies for Mapping the Extracellular Interactome

  Almo, S. C. & Almo, S. C.

  National Human Genome Research Institute

  9/24/15 → 6/30/19

  Project: Research project

  • Technology 100%
  • Membrane Proteins 72%
  • Proteins 64%
  • Automation 53%
  • Proteome 45%

• Technologies for Mapping the Extracellular Interactome

  Almo, S. C.

  9/24/15 → 6/30/19

  Project: Research project

  • Membrane Proteins 100%
  • Proteins 88%
  • Technology 78%
  • Automation 74%
  • Proteome 62%

• Chemoenzymatic methods for the detection of cell-surface glycans

  Wu, P.

  National Institutes of Health

  8/15/15 → 7/31/19

  Project: Research project

  • Polysaccharides 100%
  • Glycosylation 49%
  • Lectins 17%
  • Glycomics 12%
  • Lung Neoplasms 11%

• PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE

  Meek, T., Schramm, V. L. & Tyler, P.

  National Institute of Allergy and Infectious Diseases

  9/25/17 → 8/31/19

  Project: Research project

  • Purine 100%
  • Hypoxanthine 21%
  • Parasitic 21%
  • Nucleotide 14%
  • Transition State 14%

• Fundamental Studies of RNA Folding

  Herschlag, D., Altman, R. B., Brenowitz, M. D., Chu, S., Doniach, S. & Pollack, L.

  6/6/03 → 3/31/20

  Project: Research project

  • RNA 100%
  • RNA Folding 63%
  • Molecular Biology 16%
  • Systems Biology 12%
  • Static Electricity 12%

• Time-resolved small angle X-ray scattering

  Brenowitz, M. D., Pollack, L., Steven, C., Altman, R. B., Doniach, S. & Herschlag, D.

  1/1/01 → 3/31/20

  Project: Research project

  • folding 100%
  • x ray scattering 36%
  • scattering 16%
  • probes 13%
  • characterization 12%

• Methylthioadenosine Phosphorylase and AdoMet Synthetase in Cancer

  Schramm, V. L. & Schramm, V. L.

  National Cancer Institute

  9/11/08 → 4/30/20

  Project: Research project

  • DNA Methylation 100%
  • Transition State 88%
  • Human Metabolite 84%
  • 5'-methylthioadenosine phosphorylase 82%
  • Effective Dose 78%

• Bacterial N-Acetyltransferases: Resistance to Regulation

  Blanchard, J. S., Rose, S. A. & Rose, S. A.

  5/1/04 → 4/30/20

  Project: Research project

  • Acetyltransferases 100%
  • Acetylation 67%
  • ribosomal protein S18 51%
  • ribosomal protein S5 48%
  • aminoglycoside acetyltransferase 48%

• Transition State Analogues as Modulators of DNA Methylation

  Schramm, V. L., Rose, S. A. & Rose, S. A.

  9/11/08 → 4/30/20

  Project: Research project

  • 5'-methylthioadenosine phosphorylase 100%
  • DNA Methylation 46%
  • Neoplasms 39%
  • CpG Islands 34%
  • Methyltransferases 31%

• Protein Dynamics in Enzymatic Catalysis

  Callender, R., Dyer, R. B., Schwartz, S., Schramm, V. L. & Callender, R.

  5/1/04 → 4/30/20

  Project: Research project

  • Protein 100%
  • Catalysis 77%
  • Proton Transfer 43%
  • Chemistry 42%
  • Schwartz Hydrozirconation 39%

• Bacterial N-Acetyltransferases: Resistance to Regulation

  Blanchard, J. S. & Blanchard, J. S.

  National Institute of Allergy and Infectious Diseases

  5/1/04 → 4/30/20

  Project: Research project

  • Acetyltransferases 100%
  • Proteins 26%
  • Acetylation 26%
  • Mycobacterium tuberculosis 23%
  • ribosomal protein S18 16%

• Protein Dynamics in Enzymatic Catalysis

  Callender, R. & Dyer, R. B.

  National Institute of General Medical Sciences

  5/1/04 → 4/30/20

  Project: Research project

  • Catalysis 100%
  • Enzymes 90%
  • Proteins 76%
  • Protein 36%
  • Vibration 20%

• MOTILITY AND INVASION

  Condeelis, J. S., Backer, J. M., Bresnick, A. R., Pollard, J. W., Segall, J. E., Stanley, R. E. & Condeelis, J. S.

  National Cancer Institute

  6/1/03 → 5/31/20

  Project: Research project

  • Macrophages 100%
  • metastasis 93%
  • Neoplasms 84%
  • neoplasms 69%
  • macrophages 65%

• Tumor Progression and Metastasis

  Bresnick, A. R., Pollard, J. W., Segall, J. E., Backer, J. M., Condeelis, J. S., Pollard, J. W., Condeelis, J. S., Backer, J. M. & Bresnick, A. R.

  1/1/01 → 5/31/20

  Project: Research project

• Chemoenzymatic methods for the detection of cellsurface glycans

  Wu, P.

  National Institute of General Medical Sciences

  8/15/15 → 7/31/20

  Project: Research project

  • Polysaccharides 100%
  • Glycosylation 48%
  • Lectins 16%
  • Lung Neoplasms 12%
  • Glycomics 11%

• Structural basis of allostery and mechanical properties of F-actin

  Almo, S. C.

  8/1/16 → 7/31/20

  Project: Research project

  • Actins 100%
  • Microfilament Proteins 66%
  • Protein Subunits 57%
  • Cryoelectron Microscopy 45%
  • Protein Binding 33%

• Chemical tools for studying fucosylated glycans

  Wu, P.

  National Institutes of Health

  9/15/10 → 7/31/20

  Project: Research project

  • Fucoside 100%
  • Microarrays 22%
  • Lipid 13%
  • Guanidine 11%
  • Bilayer Membrane 11%

• Structural basis of allostery and mechanical properties of F-actin

  Almo, S. C., Almo, S. C. & Volkmann, N.

  National Institute of General Medical Sciences

  8/1/16 → 7/31/20

  Project: Research project

  • Actins 100%
  • Microfilament Proteins 71%
  • Protein Subunits 62%
  • Cryoelectron Microscopy 49%
  • Protein Binding 36%

• Studies on Pol III-Associated Leukodystrophy

  Moir, R. D., Willis, I. M. & Willis, I. M.

  National Institute of Child Health and Human Development

  3/1/19 → 2/28/21

  Project: Research project

  • Mutation 100%
  • Anodontia 87%
  • Genetic Suppression 83%
  • RNA Polymerase III 82%
  • Developmental Disabilities 74%

• Studies on Pol III-Associated Leukodystrophy

  Moir, R. D. & Willis, I. M.

  3/1/19 → 2/28/21

  Project: Research project

  • Mutation 100%
  • Anodontia 87%
  • Genetic Suppression 83%
  • RNA Polymerase III 82%
  • Developmental Disabilities 74%