Research Output 1988 2020

2008
32 Citations (Scopus)

Type-2 alkenes mediate synaptotoxicity in neurodegenerative diseases

LoPachin, R. M., Gavin, T. & Barber, D. S., Sep 2008, In : NeuroToxicology. 29, 5, p. 871-882 12 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Acrolein
Alkenes
Neurodegenerative Diseases
Derivatives
2007
6 Citations (Scopus)

General anesthesia and methylenetetrahydrofolate reductase deficiency

Shay, H., Frumento, R. J. & Bastien, A., Nov 2007, In : Journal of Anesthesia. 21, 4, p. 493-496 4 p.

Research output: Contribution to journalArticle

General Anesthesia
Methylenetetrahydrofolate Reductase (NADPH2)
Mutation
Arteriosclerosis
Nitrous Oxide

Intubation and ventilatory challenges in post-pneumonectomy patients with a bronchopleural fistula

Rubin, P., Cohen, E. & Apinis, A., 2007, In : Applied Cardiopulmonary Pathophysiology. 11, 4, p. 71-72 2 p.

Research output: Contribution to journalArticle

Pneumonectomy
Intubation
Fistula
61 Citations (Scopus)

Neurotoxic mechanisms of electrophilic type-2 Alkenes: Soft-soft interactions described by quantum mechanical parameters

LoPachin, R. M., Gavin, T., Geohagen, B. C. & Das, S., Aug 2007, In : Toxicological Sciences. 98, 2, p. 561-570 10 p.

Research output: Contribution to journalArticle

Alkenes
Acrylamide
Cysteine
Acetylcysteine
Rate constants
42 Citations (Scopus)

Proteomic analysis of rat striatal synaptosomes during acrylamide intoxication at a low dose rate

Barber, D. S., Stevens, S. & LoPachin, R. M., Nov 2007, In : Toxicological Sciences. 100, 1, p. 156-167 12 p.

Research output: Contribution to journalArticle

Corpus Striatum
Synaptosomes
Acrylamide
Proteomics
Isotope Labeling
50 Citations (Scopus)

Structure-toxicity analysis of Type-2 Alkenes: In vitro neurotoxicity

LoPachin, R. M., Barber, D. S., Geohagen, B. C., Gavin, T., He, D. & Das, S., Jan 2007, In : Toxicological Sciences. 95, 1, p. 136-146 11 p.

Research output: Contribution to journalArticle

Acrolein
Acrylamide
Alkenes
Sulfhydryl Compounds
Toxicity
149 Citations (Scopus)
Intracranial Aneurysm
Subarachnoid Hemorrhage
Nervous System
Insulin
Mortality
2006
46 Citations (Scopus)

Acrylamide inhibits dopamine uptake in rat striatal synaptic vesicles

LoPachin, R. M., Barber, D. S., He, D. & Das, S., Jan 2006, In : Toxicological Sciences. 89, 1, p. 224-234 11 p.

Research output: Contribution to journalArticle

Corpus Striatum
Acrylamide
Synaptic Vesicles
Rats
Dopamine
9 Citations (Scopus)

Anesthetic management of staged separation of craniopagus conjoined twins

Girshin, M., Broderick, C. H., Patel, D., Chacko, S., Reddy, S. G., Staffenberg, D., Goodrich, J. T. & Wasnick, J., Mar 2006, In : Paediatric Anaesthesia. 16, 3, p. 347-351 5 p.

Research output: Contribution to journalArticle

Surgical Blood Loss
Conjoined Twins
Hemodilution
Brain Edema
Anesthetics
27 Citations (Scopus)
Deep Hypothermia Induced Circulatory Arrest
Near-Infrared Spectroscopy
Neck
Oxygen
Oximetry

Craniotomies and structured peer review of perioperative adverse outcomes

Nahar, A., Lu, G., Levine, R., Lagasse, R. & Joseph, V. A., 2006, In : Journal of Neurosurgical Anesthesiology. 18, 4, p. 64-67 4 p.

Research output: Contribution to journalArticle

Peer Review
Craniotomy
86 Citations (Scopus)

Synaptic cysteine sulfhydryl groups as targets of electrophilic neurotoxicants

LoPachin, R. M. & Barber, D. S., Dec 2006, In : Toxicological Sciences. 94, 2, p. 240-255 16 p.

Research output: Contribution to journalArticle

Cysteine
Nitric Oxide
Research
Acrolein
Proteins
2005
30 Citations (Scopus)

2,5-Hexanedione-induced changes in the neurofilament subunit pools of rat peripheral nerve

LoPachin, R. M., He, D. & Reid, M. L., Mar 2005, In : NeuroToxicology. 26, 2, p. 229-240 12 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Peripheral Nerves
Rats
Axons
Atrophy
60 Citations (Scopus)
Acrylamide
Animals
Animal Models
Chemical Industry
Muscle Weakness
1 Citation (Scopus)

A report of a case: Anesthetic management of a parturient with severe thrombotic stenosis of a mechanical aortic valve - An exercise in coordination of subspecialties

Inyang, A. N., Jackson, M., Kumar, A., Nychka, A., Leyvi, G., Zhuravlev, I., Plestis, K. & Wasnick, J., Sep 2005, In : Seminars in Cardiothoracic and Vascular Anesthesia. 9, 3, p. 261-263 3 p.

Research output: Contribution to journalArticle

Case Management
Aortic Valve
Anesthetics
Pathologic Constriction
Thrombosis
9 Citations (Scopus)

Case 3 - 2005 Risk and benefits of cerebrospinal fluid drainage during thoracoabdominal aortic aneurysm surgery

Leyvi, G., Ramachandran, S., Wasnick, J. D., Plestis, K., Cheung, A. T. & Drenger, B., Jun 2005, In : Journal of Cardiothoracic and Vascular Anesthesia. 19, 3, p. 392-399 8 p.

Research output: Contribution to journalArticle

Cerebrospinal Fluid Pressure
Intraoperative Monitoring
Thoracic Aortic Aneurysm
Paraplegia
Abdominal Aortic Aneurysm
20 Citations (Scopus)

Caudal anesthesia in pediatric cardiac surgery: Does it affect outcome?

Leyvi, G., Taylor, D. G., Reith, E., Stock, A., Crooke, G. & Wasnick, J. D., Dec 2005, In : Journal of Cardiothoracic and Vascular Anesthesia. 19, 6, p. 734-738 5 p.

Research output: Contribution to journalArticle

Caudal Anesthesia
Thoracic Surgery
Length of Stay
Pediatrics
Pediatric Intensive Care Units
2 Citations (Scopus)

Intraoperative off-bypass management of the ABIOMED AB5000 Ventricle

Leyvi, G., Taylor, D. G., Hong, S., Garcia, J. P., Crooke, G. & Wasnick, J. D., Feb 2005, In : Journal of Cardiothoracic and Vascular Anesthesia. 19, 1, p. 76-78 3 p.

Research output: Contribution to journalArticle

Heart-Assist Devices
1 Citation (Scopus)

Intraoperative oxygen desaturation and electrocardiographic changes in a patient with Hanhart syndrome

Girshin, M., Parikh, S. R., Leyvi, G., Lakhani, P., Lo, L. W. & Wasnick, J. D., Aug 2005, In : Journal of Cardiothoracic and Vascular Anesthesia. 19, 4, p. 546-547 2 p.

Research output: Contribution to journalArticle

Congenital Limb Deformities
Thoracic Radiography
Multiple Abnormalities
Intraoperative Monitoring
Aspiration Pneumonia
1 Citation (Scopus)

Methemoglobinemia in critically ill burned patients

Lebowitz, P. W., Mar 2005, In : American Journal of Critical Care. 14, 2, p. 102-103 2 p.

Research output: Contribution to journalArticle

Methemoglobinemia
Burns
Critical Illness
111 Citations (Scopus)

Protein adduct formation as a molecular mechanism in neurotoxicity

LoPachin, R. M. & DeCaprio, A. P., Aug 2005, In : Toxicological Sciences. 86, 2, p. 214-225 12 p.

Research output: Contribution to journalArticle

Proteins
Nucleophiles
Covalent bonds
Acrylamide
Xenobiotics
7 Citations (Scopus)

Transient right ventricular failure and transient weakness: A TEE diagnosis

Leyvi, G., Rhew, E., Crooke, G. & Wasnick, J. D., Jun 2005, In : Journal of Cardiothoracic and Vascular Anesthesia. 19, 3, p. 406-408 3 p.

Research output: Contribution to journalArticle

Equipment Failure
Right Ventricular Dysfunction
Air Embolism
Heart-Assist Devices
Cardiogenic Shock
84 Citations (Scopus)

Utility of ultrasound-guided central venous cannulation in pediatric surgical patients: A clinical series

Leyvi, G., Taylor, D. G., Reith, E. & Wasnick, J. D., Nov 2005, In : Paediatric Anaesthesia. 15, 11, p. 953-958 6 p.

Research output: Contribution to journalArticle

Catheterization
Pediatrics
Jugular Veins
Thoracic Surgery
Weights and Measures
10 Citations (Scopus)

γ-Diketone central neuropathy: Quantitative analyses of cytoskeletal components in myelinated axons of the rat rubrospinal tract

LoPachin, R. M., Jortner, B. S., Reid, M. L. & Monir, A., Dec 2005, In : NeuroToxicology. 26, 6, p. 1021-1030 10 p.

Research output: Contribution to journalArticle

Axons
Rats
Neurofilament Proteins
Intermediate Filaments
Microtubules
2004
25 Citations (Scopus)

2,5-Hexanedione-induced changes in the monomeric neurofilament protein content of rat spinal cord fractions

LoPachin, R. M., He, D., Reid, M. L. & Opanashuk, L. A., Jul 1 2004, In : Toxicology and Applied Pharmacology. 198, 1, p. 61-73 13 p.

Research output: Contribution to journalArticle

Neurofilament Proteins
Intermediate Filaments
Rats
Spinal Cord
Polymers
6 Citations (Scopus)

Acrylamide toxicities and food safety: Session IV summary and research needs

LoPachin, R. M. & Canady, R. A., Jun 2004, In : NeuroToxicology. 25, 4 SPEC. ISS., p. 507-509 3 p.

Research output: Contribution to journalArticle

Acrylamide
Food Safety
Research
9 Citations (Scopus)

Arterial versus venous sampling for activated coagulation time measurements during cardiac surgery: A comparative study

Leyvi, G., Zhuravlev, I., Inyang, A., Vinluan, J., Ramachandran, S., Lehning, E. J. & Wasnick, J. D., Oct 2004, In : Journal of Cardiothoracic and Vascular Anesthesia. 18, 5, p. 573-580 8 p.

Research output: Contribution to journalArticle

Thoracic Surgery
Heparin
Swan-Ganz Catheterization
Protamines
Cardiopulmonary Bypass

Functional Changes in the Hemiplegic Upper Limb after Botulinum Toxin Type A Injection into One Elbow Flexor: Single-Blind Study

Chao, J. Y., Flanagan, S., Simpson, D. & Gracies, J-M., Aug 31 2004, p. S72-S72.

Research output: Contribution to conferenceAbstract

Single-Blind Method
Type A Botulinum Toxins
Elbow
Upper Extremity
Hemiplegia
63 Citations (Scopus)

In vivo and in vitro effects of acrylamide on synaptosomal neurotransmitter uptake and release

LoPachin, R. M., Schwarcz, A. I., Gaughan, C. L., Mansukhani, S. & Das, S., Mar 2004, In : NeuroToxicology. 25, 3, p. 349-363 15 p.

Research output: Contribution to journalArticle

Acrylamide
Neurotransmitter Agents
Iodoacetic Acid
Synaptosomes
Proteins
3 Citations (Scopus)

Monitoring and Analysis of Outcome Studies

Joseph, V. A. & Lagasse, R. S., Mar 2004, In : International Anesthesiology Clinics. 42, 2, p. 113-130 18 p.

Research output: Contribution to journalArticle

Biomedical Technology Assessment
Outcome Assessment (Health Care)
Insurance Claim Review
Databases
Guidelines
48 Citations (Scopus)

Proteomic analysis of acrylamide-protein adduct formation in rat brain synaptosomes

Barber, D. S. & LoPachin, R. M., Dec 1 2004, In : Toxicology and Applied Pharmacology. 201, 2, p. 120-136 17 p.

Research output: Contribution to journalArticle

Synaptosomes
Acrylamide
Proteomics
Rats
Brain
169 Citations (Scopus)

The changing view of acrylamide neurotoxicity

LoPachin, R. M., Jun 2004, In : NeuroToxicology. 25, 4 SPEC. ISS., p. 617-630 14 p.

Research output: Contribution to journalArticle

Acrylamide
Membrane Fusion
Laboratory Animals
Food
Animals
23 Citations (Scopus)

γ-Diketone neuropathy: Axon atrophy and the role of cytoskeletal protein adduction

LoPachin, R. M. & DeCaprio, A. P., Aug 15 2004, In : Toxicology and Applied Pharmacology. 199, 1, p. 20-34 15 p.

Research output: Contribution to journalArticle

Cytoskeletal Proteins
Atrophy
Axons
Swelling
Toxicity
2003
116 Citations (Scopus)

Acrylamide axonopathy revisited

LoPachin, R. M., Balaban, C. D. & Ross, J. F., May 1 2003, In : Toxicology and Applied Pharmacology. 188, 3, p. 135-153 19 p.

Research output: Contribution to journalArticle

Acrylamide
Axons
Purkinje Cells
Cerebellum
Brain
13 Citations (Scopus)

Acrylamide neuropathy. II. Spatiotemporal characteristics of nerve cell damage in brainstem and spinal cord.

Lehning, E. J., Balaban, C. D., Ross, J. F. & LoPachin, R. M., Jan 2003, In : NeuroToxicology. 24, 1, p. 109-123 15 p.

Research output: Contribution to journalArticle

Acrylamide
Brain Stem
Neurons
Spinal Cord
Axons
42 Citations (Scopus)

Acrylamide neuropathy. III. Spatiotemporal characteristics of nerve cell damage in forebrain.

Lehning, E. J., Balaban, C. D., Ross, J. F. & LoPachin, R. M., Jan 2003, In : NeuroToxicology. 24, 1, p. 125-136 12 p.

Research output: Contribution to journalArticle

Acrylamide
Prosencephalon
Neurons
Nerve Degeneration
Axons
25 Citations (Scopus)

Application of Proteomics to the Study of Molecular Mechanisms in Neurotoxicology

LoPachin, R. M., Jones, R. C., Patterson, T. A., Slikker, W. & Barber, D. S., Dec 2003, In : NeuroToxicology. 24, 6, p. 761-775 15 p.

Research output: Contribution to journalArticle

Proteomics
Proteome
Proteins
Post Translational Protein Processing
Multiprotein Complexes
Acrylamide
Toxicology
Brain Stem
Spinal Cord
Neurons
19 Citations (Scopus)

Why can't my procedures start on time?

Lebowitz, P. W., Mar 2003, In : AORN Journal. 77, 3, p. 594-597 4 p.

Research output: Contribution to journalArticle

Operating Rooms
Appointments and Schedules
Surgeons
23 Citations (Scopus)

γ-Diketone central neuropathy: Quantitative morphometric analysis of axons in rat spinal cord white matter regions and nerve roots

LoPachin, R. M., Jortner, B. S., Reid, M. L. & Das, S., Nov 15 2003, In : Toxicology and Applied Pharmacology. 193, 1, p. 29-46 18 p.

Research output: Contribution to journalArticle

Axons
Rats
Spinal Cord
Chemical analysis
Spinal Nerve Roots
2002
53 Citations (Scopus)

Acrylamide neuropathy I. Spatiotemporal characteristics of nerve cell damage in rat cerebellum

Lehning, E. J., Balaban, C. D., Ross, J. F., Reid, M. A. & LoPachin, R. M., Sep 2002, In : NeuroToxicology. 23, 3, p. 397-414 18 p.

Research output: Contribution to journalArticle

Acrylamide
Purkinje Cells
Cerebellum
Neurons
Rats
23 Citations (Scopus)

Acrylamide neuropathy II. Spatiotemporal characteristics of nerve cell damage in brainstem and spinal cord

Lehning, E. J., Balaban, C. D., Ross, J. F. & LoPachin, R. M., Sep 2002, In : NeuroToxicology. 23, 3, p. 415-429 15 p.

Research output: Contribution to journalArticle

Acrylamide
Brain Stem
Neurons
Spinal Cord
Axons
76 Citations (Scopus)

Nerve terminals as the primary site of acrylamide action: A hypothesis

LoPachin, R. M., Ross, J. F. & Lehning, E. J., May 2002, In : NeuroToxicology. 23, 1, p. 43-59 17 p.

Research output: Contribution to journalArticle

Acrylamide
SNARE Proteins
Nerve Degeneration
Membranes
Axons
96 Citations (Scopus)

Neurological evaluation of toxic axonopathies in rats: Acrylamide and 2,5-hexanedione

LoPachin, R. M., Ross, J. F., Reid, M. L., Das, S., Mansukhani, S. & Lehning, E. J., May 2002, In : NeuroToxicology. 23, 1, p. 95-110 16 p.

Research output: Contribution to journalArticle

Acrylamide
Poisons
Hindlimb
Rats
Monomers
21 Citations (Scopus)
Acrylamide
Animals
Axons
2001
24 Citations (Scopus)

An investigation of a new activated clotting time "MAX-ACT" in patients undergoing extracorporeal circulation

Leyvi, G., Shore-Lesserson, L., Harrington, D., Vela-Cantos, F. & Hossain, S., 2001, In : Anesthesia and Analgesia. 92, 3, p. 578-583 6 p.

Research output: Contribution to journalArticle

Extracorporeal Circulation
Heparin
Cardiopulmonary Bypass
Hemodilution
Hypothermia
32 Citations (Scopus)

Determination of acrylamide and glycidamide in rat plasma by reversed-phase high performance liquid chromatography

Barber, D. S., Hunt, J., LoPachin, R. M. & Ehrich, M., Jul 15 2001, In : Journal of Chromatography B: Biomedical Sciences and Applications. 758, 2, p. 289-293 5 p.

Research output: Contribution to journalArticle

Acrylamide
High performance liquid chromatography
Rats
Plasmas
Epoxy Compounds
59 Citations (Scopus)

Effects of ion channel blockade on the distribution of Na, K, Ca and other elements in oxygen-glucose deprived CA1 hippocampal neurons

LoPachin, R. M., Gaughan, C. L., Lehning, E. J., Weber, M. L. & Taylor, C. P., Apr 4 2001, In : Neuroscience. 103, 4, p. 971-983 13 p.

Research output: Contribution to journalArticle

Ion Channels
Reperfusion
Ions
Oxygen
Neurons
84 Citations (Scopus)

Metabolism, toxicokinetics and hemoglobin adduct formation in rats following subacute and subchronic acrylamide dosing

Barber, D. S., Hunt, J. R., Ehrich, M. F., Lehning, E. J. & LoPachin, R. M., 2001, In : NeuroToxicology. 22, 3, p. 341-353 13 p.

Research output: Contribution to journalArticle

Acrylamide
Metabolism
Rats
Hemoglobins
Axons
30 Citations (Scopus)
Operating Rooms
Monte Carlo Method
Mathematics
Surgeons